Hydrophilic siloxane oligomer, silicon hydrogel, corneal contact lens and preparation method

A siloxane oligomer, corneal contact lens technology, applied in the field of corneal contact lens and preparation, hydrophilic siloxane oligomer, and silicon hydrogel, can solve the problem of low oxygen supply, difficult compatibility, It is difficult to maintain hydrophilicity, so as to achieve the effect of comfortable wearing and good oxygen permeability

Active Publication Date: 2016-03-16
JIANGSU HORIEN CONTACT LENS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above traditional lens materials have low oxygen supply, and the existing sili...

Method used

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  • Hydrophilic siloxane oligomer, silicon hydrogel, corneal contact lens and preparation method
  • Hydrophilic siloxane oligomer, silicon hydrogel, corneal contact lens and preparation method
  • Hydrophilic siloxane oligomer, silicon hydrogel, corneal contact lens and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A kind of hydrophilic siloxane oligomer, the molecular formula of this siloxane oligomer is as follows:

[0049]

[0050] , or for

[0051] Wherein, the structural formula of X is as follows:

[0052]

[0053] Wherein, the value range of a is an integer between 10 and 23, the value of b is an integer between 3 and 8, and the value of c is an integer between 3 and 40.

[0054] The molecular formula of the above-mentioned hydrophilic siloxane oligomer has two forms: M1 and M2. There are longer PEG chains at both ends of the siloxane oligomer. Since the PEG chain segment has good hydrophilicity and can be miscible with hydrophilic monomers, the siloxane oligomer can be dissolved without solvent. It has excellent compatibility with hydrophilic monomers. In the case of good mutual solubility, siloxane oligomers can be used to make contact lenses with excellent light transmission.

[0055] The siloxane oligomer in this embodiment is a siloxane tri-block copolymer,...

Embodiment 1

[0066] Take 14.1 g of diol (the structural formula is shown in the following formula w1) and dissolve it in an appropriate amount of dichloromethane in a three-necked flask, then add 3 mL of catalyst dibutyltin dilaurate, and stir magnetically. Dissolve 3.1 g of isocyanoethyl methacrylate (IEM) in dichloromethane, mix well, and drop it into a three-necked flask at room temperature under constant pressure. Then heated to 60 ° C reflux reaction 10h. After the reaction, the obtained liquid was washed with petroleum ether, allowed to stand to separate layers, and the liquid in the lower layer was distilled under reduced pressure to obtain a siloxane oligomer, which was designated as M1-w1. The synthetic equation is shown in the chemical reaction formula of the above-mentioned first method.

[0067]

example 2

[0069] Take 14.1g of diol (the structural formula is shown in the above formula w1), 2.8g of glycidyl methacrylate (GMA), 100 μL of trifluoromethanesulfonic acid, magnetic stirring, reflux reaction at 20°C for 24h, and vacuum distillation after the reaction. The obtained siloxane oligomer is denoted as M2-w1. The synthetic formula is shown in the chemical reaction formula of the above-mentioned second method.

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Abstract

The present invention discloses a hydrophilic siloxane oligomer, the siloxane oligomer and various hydrophilic monomers can be well intermixed without a solvent for helping solubilization, a silicon hydrogel material with good light transmission can be prepared; a silicon hydrogel is also provided, the silicon hydrogel is prepared from 5 to 45 parts of the siloxane oligomer, 55 to 95 parts of a hydrophilic monomer, 0 to 20 parts of a small molecule silicon monomer, and an initiator and a crosslinking agent by polymerization reaction; the silicon hydrogel has a good hydrophilic property and oxygen permeability; meanwhile a corneal contact lens is also provided, the corneal contact lens is prepared from the silicon hydrogel material, and the corneal contact lens has good oxygen permeability, strong hydrophilicity and wearing comfortability.

Description

technical field [0001] The invention belongs to the field of materials used for preparing contact lens lenses, and in particular relates to a hydrophilic siloxane oligomer, silicon hydrogel, corneal contact lens and a preparation method. Background technique [0002] Contact lenses, also known as contact lenses, are lenses that are worn directly on the human eyeball and are mainly used to correct vision. Along with people's requirement for beauty, more and more people wear colored contact lenses to increase the aesthetic feeling of eyes, and some personnel who are engaged in special work wear contact lenses to protect eyeballs. With the development of science and technology, the lens materials of contact lenses have also been updated. [0003] The earliest developed lens material is polymethyl methacrylate, which is a rigid contact lens. Due to its hard material, it is easy to wear the cornea, has poor wettability, and low oxygen permeability. It is easy to cause eye discom...

Claims

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Application Information

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IPC IPC(8): C08G77/38C08G77/388C08F290/06C08F226/10C08F220/06C08F220/28C08F220/54C08F226/02C08F230/08G02C7/04
CPCC08F290/06C08G77/38C08G77/388G02C7/04C08F226/10C08F220/06C08F220/281C08F220/54C08F226/02C08F230/08
Inventor 张雪勤陶慧文林保平陈平韩雪莲
Owner JIANGSU HORIEN CONTACT LENS
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