Medicine for treating primary osteoporosis through kidney-tonifying, spleen-strengthening and blood-stasis-removing method

A technology for osteoporosis and drugs, which is applied in the direction of drug combination, drug delivery, and medical raw materials derived from leeches/worms. The effect of repairing microfractures

Inactive Publication Date: 2016-04-20
王平平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vertebral fractures often cause chronic low back pain, or long-term bed rest due to kyphosis or scoliosis, pain, movement disorders, etc., resulting in a significant decline in quality of life

Method used

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  • Medicine for treating primary osteoporosis through kidney-tonifying, spleen-strengthening and blood-stasis-removing method
  • Medicine for treating primary osteoporosis through kidney-tonifying, spleen-strengthening and blood-stasis-removing method
  • Medicine for treating primary osteoporosis through kidney-tonifying, spleen-strengthening and blood-stasis-removing method

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preparation example Construction

[0055] The present invention also provides a preparation method of the above-mentioned medicine for treating osteoporosis, which comprises:

[0056] The first step is to take Epimedium, Antler Glue, Turtle Shell Glue, Dog Ridge, Achyranthes Achyranthes, Trionyx Carapace, Rhizoma Drynaria, Dipsacus, leech, Osmanthus bone, Rock Ginger Seven and Jindaocai according to the above weight parts , mixed together, soaked in ethanol and extracted by percolation, and the extract was concentrated to obtain the extract;

[0057] In the second step, the remaining components of the crude drug are taken according to the above parts by weight, mixed together, extracted with water, and the volatile oil and filtrate are collected, the volatile oil is clathrated with β-cyclodextrin, and the filtrate is concentrated into an extract;

[0058] In the third step, the extract obtained in the first step, the extract obtained in the second step and the β-cyclodextrin inclusion compound of the volatile o...

Embodiment 1

[0063] Embodiment 1 oral liquid 1

[0064] Combine 30g of epimedium, 40g of deer horn glue, 40g of tortoise shell glue, 30g of dog ridge, 20g of Achyranthes bidentata, 20g of made turtle shell, 30g of Drynaria fortunei, 20g of Dipsacus, 10g of leech, 10g of Osmanthus bone, 10g of rock ginger seven and 10g of golden knife vegetables are washed separately, pulverized by a pulverizer, and the powder fineness reaches 100 mesh, mixed together, adopting the percolation method and using ethanol as a solvent with an alcohol concentration of 70%, and immersing for 24 hours at a speed of 3ml per minute. Percolation, collecting the percolation liquid, filtering, concentrating to 60 ℃ extract with a relative density of 1.20, the application amount of ethanol is 3.2kg, 20g of dodder, 15g of cinnamon, 20g of Eucommia ulmoides, 30g of astragalus, 20g of rehmannia glutinosa, and 20g of dogwood , Chinese yam 30g, Poria cocos 20g, Moutan cortex 20g, Alisma 10g, Angelica 30g, Radix Paeoniae Alba...

Embodiment 2

[0065] Embodiment 2 oral liquid 2

[0066] Combine 30g of epimedium, 40g of deer horn glue, 35g of tortoise shell glue, 25g of dog ridge, 20g of Achyranthes bidentata, 15g of made turtle shell, 30g of Drynaria fortunei, 15g of Dipsacus, 10g of leech, 10g of Osmanthus bone, 10g of rock ginger seven and 10g of golden knife vegetables are washed separately, pulverized by a pulverizer, and the powder fineness reaches 100 mesh, mixed together, adopting the percolation method and using ethanol as a solvent with an alcohol concentration of 70%, and immersing for 24 hours at a speed of 3ml per minute. Percolation, collecting the percolation liquid, filtering, concentrating to 60 ℃ the extract with a relative density of 1.20, the application amount of ethanol is 3kg, 15g of dodder, 10g of cinnamon, 15g of Eucommia ulmoides, 25g of astragalus, 15g of rehmannia glutinosa, 15g of cornus officinalis, Yam 30g, Poria cocos 15g, Moutan cortex 15g, Alisma 10g, Angelica 25g, Radix Paeoniae Alba...

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Abstract

The invention provides a medicine for treating primary osteoporosis through a kidney-tonifying, spleen-strengthening and blood-stasis-removing method. The medicine is prepared from epimedium, antler gum, tortoise-plastron glue, semen cuscutae, cinnamon, rhizoma cibotii, achyranthes roots, eucommia bark, turtle shells, drynaria rhizome, astragalus, teasel roots, dried rehmannia roots, cornus officinalis, Chinese yam, poria cocos, moutan bark, rhizoma alismatis, radix angelica sinensis, white peony roots, radix salvia, leeches, dicranopteris linearis, aster striatus, orixa japonica and raw licorice roots. The medicine can improve the shape of bone trabecula by inhibiting bone loss caused by osteoclast, effectively improves ultrastructures of osteoporotic cancellous bones, increases bone mass, prevents and repairs microscopic fracture, and achieves the curative effect of preventing osteoporosis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating primary osteoporosis with the method of invigorating the kidney, invigorating the spleen and removing blood stasis. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic metabolic bone disease characterized by decreased bone mass, degenerative changes in the microstructure of bone tissue, increased bone fragility, and susceptibility to fracture. It is clinically divided into primary and secondary. Primary osteoporosis is divided into two types: type I is postmenopausal osteoporosis, which mostly occurs in middle-aged and elderly women aged 50-70, and mainly occurs in the spine and radius. Distal; type Ⅱ is senile osteoporosis, mostly in the elderly over 70 years old, and mostly occurs in the upper end of the vertebrae and femur. According to the survey data of the sixth national census in Guangdong Province in 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/08A61P19/10A61K35/32A61K35/586A61K35/62
CPCA61K9/0095A61K9/08A61K35/32A61K35/586A61K35/62A61K36/076A61K36/11A61K36/126A61K36/185A61K36/21A61K36/232A61K36/296A61K36/39A61K36/40A61K36/46A61K36/481A61K36/484A61K36/537A61K36/54A61K36/65A61K36/71A61K36/804A61K36/85A61K36/884A61K36/8945A61K47/12A61K47/26A61K2236/13A61K2236/15A61K2236/331A61K2236/333A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 王平平
Owner 王平平
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