Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition

A technology of composition and medicine, which is applied in the field of pharmaceutical composition with calming effect and its preparation, can solve problems such as inability to be treated fundamentally, dependence on sleeping pills, serious diseases, etc., and achieve the goal of improving drug efficacy, brain-invigorating effect, and obvious effect Effect

Inactive Publication Date: 2016-05-11
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the usual way for patients with insomnia to alleviate this disease is to take western medicine sleeping pills, but they cannot be fundamentally treated. Long-term use will form dependence on sleeping pills. disease

Method used

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  • Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition
  • Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Chinese medicine raw materials: agarwood 500g; lavender (dry whole plant) 500g; calamus (dry whole plant) 500g.

[0035] Preparation:

[0036] S1. After mixing agarwood, lavender and calamus, reflux extraction with 95% ethanol with a volume fraction of 3 times, 1 hour each time, filter, combine the extracts, and concentrate to obtain an ethanol extract;

[0037] S2. Put the obtained ethanol extract on a macroporous resin column, first eluting with 60% ethanol to remove impurities, and then eluting with 85% ethanol to collect 85% ethanol eluate , Concentrate into a thick paste, add appropriate amount of dextrin and sucrose, and mix to make granules. 10g per bag.

Embodiment 2

[0039] Chinese medicine raw materials: agarwood 500g; lavender (dry whole plant) 500g; calamus (dry whole plant) 1000g.

[0040] Preparation:

[0041] S1. After mixing agarwood, lavender and calamus, reflux extraction with 95% ethanol with a volume fraction of 3 times, 1 hour each time, filter, combine the extracts, and concentrate to obtain an ethanol extract;

[0042] S2. Put the obtained ethanol extract on a macroporous resin column, first eluting with 40% ethanol to remove impurities, and then eluting with 70% ethanol to collect 70% ethanol eluate , Concentrate into a thick paste, add proper amount of starch, mix well, and make 1000 capsules.

Embodiment 3

[0044] Chinese medicine raw materials: Agarwood 1000g; Lavender (dry whole plant) 500g; Acorus calamus (dry whole plant) 500g.

[0045] Preparation:

[0046] S1. Mix agarwood, lavender and calamus and extract with methanol reflux. The number of extractions is 3 times, 1 hour each time, filter, combine the extracts, and concentrate to obtain a methanol extract;

[0047] S2. Put the obtained methanol extract on a macroporous resin column, first eluting with 50% ethanol to remove impurities, and then eluting with 95% ethanol to collect the 95% ethanol eluate , Concentrated into a thick paste, add appropriate amount of calcium hydrogen phosphate, sodium starch glycolate and magnesium stearate, mix well to make 1000 tablets.

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Abstract

The invention relates to the field of traditional Chinese medicines, and particularly discloses a pharmaceutical composition with a tranquilizing effect and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 5-20 parts of agilawood, 5-20 parts of lavender and 5-20 parts of acorus tatarinowii. The preparation method comprises the following steps: (S1) mixing the agilawood, the lavender and the acorus tatarinowii, and extracting the mixture with an organic solvent to obtain an organic solvent extract; (S2) processing the obtained organic solvent extract through a macroporous resin column, carrying out elution with ethanol of which the volume fraction is 30%-60% to remove impurities and then carrying out elution with the ethanol of which the volume fraction is greater than 70%, collecting over 70% of ethanol eluent and concentrating the ethanol eluent into thick paste; and adding auxiliary materials and mixing the auxiliary materials evenly to prepare the preparation by the known technology of the technicians in the field. The pharmaceutical composition disclosed by the invention has an excellent tranquilizing effect, and simultaneously has a brain-strengthening effect.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition with soothing effect and a preparation method and application thereof. Background technique [0002] Due to the heavy pressure in modern life, the number of people suffering from insomnia in modern people is gradually increasing. These people are often upset and short of concentration. Insomnia at night leads to poor spirits during the day. Traditional Chinese medicine believes that insomnia is mainly caused by visceral imbalance and qi and blood imbalance. Sleep is a very important physiological process in human life activities. Sleep disorders usually manifest as difficulty falling asleep, waking up early, and easy to wake up. Patients often have mental fatigue, dizziness, headaches, tinnitus, palpitations, shortness of breath, inattention, and work. Phenomenon such as efficiency drop. Long-term sleep disorders easily affec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/20A61P25/00
CPCA61K36/835A61K9/1652A61K9/2059A61K9/2068A61K9/4866A61K36/53A61K36/888A61K2236/333A61K2236/55A61K2300/00
Inventor 黄晓其詹丽玲易智彪谢友良赖小平
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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