Composition for tumor examination and test paper for tumor examination

A composition and tumor technology, which is applied in the direction of chemical reaction of materials and material analysis by observing the influence of chemical indicators, can solve the problems of lack of accuracy and high false positive rate, and achieve low price, The effect of preventing false inspection

Inactive Publication Date: 2017-09-22
山田节郎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, when only polyamines in urine are measured to determine malignant tumors, the false positive rate is high and the accuracy is lacking

Method used

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  • Composition for tumor examination and test paper for tumor examination
  • Composition for tumor examination and test paper for tumor examination
  • Composition for tumor examination and test paper for tumor examination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Relationship between Urinary Indoleacetic Acid in Various Cancer Patients and Healthy Normal People

[0051] Add 0.1ml of internal standard solution indole acetic acid (IAA) to 1ml of urine of various cancer patients and non-cancer patients, add 0.01ml of ethyl acetate and 0.01ml of L-tartaric acid, centrifuge at 4000rpm for 10 minutes , the supernatant was injected into HPLC (High Performance Liquid Chromatograph, high performance liquid chromatography) to quantify IAA in urine. Information on the amount of IAA in the urine of various cancer patients and healthy normal subjects was obtained (see Table 1 and Table 2).

[0052] [Preparation of tumor examination composition]

[0053] In addition, 0.5 ml of hydrochloric acid was added to 100 ml of cinnamon oil (manufactured by Symarom Pte Ltd, production number cassia 0-3031) to separate the oil, thereby increasing the concentration of cinnamaldehyde as the main component of the supernatant (concentration: 95%) As a test...

Embodiment 2

[0064] [Production of test strips for tumor examination and screening using them]

[0065] Filter paper (ADVANTEC 101285) was immersed in a commercially available liquid mixture of 100 ml of cinnamaldehyde, 1.5 ml of hydrochloric acid, 0.3 ml of acetic acid, 1.0 mL of ethanol, and 0.5 mL of L-tartaric acid, and dried at room temperature. An aqueous solution of sodium nitrite (a solution obtained by diluting 1 ml of a 98% nitrous acid aqueous solution with 10 ml of distilled water) was sprayed on the dried filter paper, and dried again. Then, a double-sided tape was attached to one side of the filter paper and cut in the longitudinal direction to prepare a test paper piece for IAA measurement of a size of 0.5 cm×2 cm. The test paper was dipped in urine, taken out after about 5 seconds, immersed in a trichloroacetic acid solution, and taken out to check the discoloration of the test paper.

[0066] Table 3 shows the results of checking the amount of IAA based on the progression...

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Abstract

The present invention relates to a composition for tumor examination and a test paper for tumor examination. The purpose of the present invention is to provide a novel method for examining malignant tumors, which is not a blood test that damages the body, does not stress the subject, is simple and has a low false positive rate. The present invention relates to a composition for tumor examination containing an aromatic aldehyde, particularly cinnamaldehyde, and a test paper for tumor examination obtained by containing the composition for tumor examination in a filter paper and drying the composition.

Description

technical field [0001] The present invention relates to a composition for examination of tumors, especially malignant tumors, and a test paper for examination. Background technique [0002] It has been known that cancer-related substances collectively called polyamines exist in human cancer tissues. Polyamine is a low-molecular non-protein nitrogen compound, and is a substance that increases when cell proliferation or differentiation becomes active. It is considered that this polyamine is excreted in urine if a malignant tumor is present. In addition, it is known that, in particular, diacetylspermine (Diacetylspermine), which is a type of polyamine, has a higher correlation with cancer than other polyamines. Therefore, malignant tumor examination can be performed by measuring polyamines in urine, especially diacetylspermine. [0003] However, when malignant tumors are judged only by measuring polyamines in urine, the false positive rate is high and the accuracy is lacking...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78
Inventor 山田节郎
Owner 山田节郎
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