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Apparatus for leak detection

A kind of equipment and detector technology, which can solve the incomplete means of integrity testing by detecting the appearance of fluid at the leakage point, by measuring the rate of increase and deceleration of fluid, and using liquid/vacuum degree for liquid tightness measurement. Consensus and other issues, to achieve the effect of short measurement time and simple test procedures

Inactive Publication Date: 2016-05-18
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] A brief review of the prior art here shows that the means currently available for integrity testing of unfilled single-use containers before and after use are not entirely satisfactory and still suffer from a number of shortcomings

Method used

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  • Apparatus for leak detection
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Examples

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Embodiment Construction

[0046] example

[0047] foreword

[0048] Ultrasonic bag (Celsius FFT12L, Sartorius Stedim Biotech GmbH Goettingen, Germany) tests were performed using Ultrasonicspy101 (Richard Chambers GmbH, Heimstetten, Germany) or another ultrasonic capture device. The turbulent air flow over the edge of the leak generates ultrasonic waves. via 3 (Pall AG, Basel, Switzerland) or another device capable of supplying gas at a specific pressure (≦200 mbar) provides the pressure required to obtain sufficient air flow from the leak. The acoustic signal captured by the ultrasound capture device will be transmitted to the Endress+Hauser Graphic DataManger RSG40 or another device capable of presenting and recording the voltage signal. The bags under test are placed in soundproof steel cylinders where they are equipped with springs in the frame that allow the bags to expand. The handle allows the frame to be turned within the barrel during signal acquisition.

[0049] Components of a speci...

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Abstract

The invention relates to an apparatus for testing the integrity of packaging containers, comprising a detector (9) for the detection of an ultrasound signal generated by gas flow through a leak in a pressurized packaging container (3), characterized in that the apparatus comprises a test chamber (2) suitable for accommodation of a pressurized packaging container (3) and thedetector (9) being arranged such that it is to detect a gas-borne ultrasound signal generated by gas flow through a leak in a pressurized packaging container (3) inside the test chamber (2).

Description

technical field [0001] The present invention relates to an apparatus for integrity testing of empty plastic packaging articles before and / or after use, for example, as packaging articles for pharmaceuticals or pharmaceuticals. The invention also relates to methods of using the device and uses of the device. Background technique [0002] In pharmaceutical manufacturing, plastic packaging is usually designed for single-use applications (disposable). The use of single-use containers is an emerging technology due to reduced risk of cross-contamination, superior transport performance, and lower initial investment costs. Disposable containers are used especially for bulk mixing, bulk transport operations, freezing, thawing and synthesis of pharmaceutical solutions or buffer stock solutions. To meet different process requirements, single-use containers are used in a wide range of different sizes and designs. [0003] The integrity of the single-use container system is guaranteed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01M3/24G01M3/32
CPCG01M3/3281G01M3/24
Inventor J·吕姆克曼M·沙夫纳S·施耐德
Owner F HOFFMANN LA ROCHE & CO AG
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