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Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating ankylosing spondylitis

Ankylosing spondylitis and composition technology, applied in drug combinations, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of undetermined antigen properties, complicated drug prescriptions, high cost of medication, etc., and achieve curative effect Significant, conducive to quality control, stable drug effect

Inactive Publication Date: 2016-06-15
GUANGZHOU SANDE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Infection: The incidence of AS may be related to infection. Ebrimger et al. found that the detection rate of Klebsiella pneumoniae in the stool of AS patients was 79%, while that of the control group was <30%. Some cases have IgA-type wet-like factor, serum C4 and IgA levels are significantly increased, and there are circulating immune complexes (CIC) in the serum, but the nature of the antigen has not been determined. The above phenomena suggest that the immune mechanism is involved in the pathogenesis of this disease
(3) Others: Trauma, endocrine, metabolic disorders, and allergies are also suspected as pathogenic factors. In short, the etiology of this disease is unknown at present, and there is no theory that can fully explain all the manifestations of AS. It is likely to be based on genetic factors. Affected by environmental factors (including infection) and other aspects to cause disease
Although the traditional Chinese medicine of this invention has a certain effect of expelling wind and dehumidification, promoting menstrual flow and relieving pain, promoting blood circulation and removing blood stasis, and strengthening muscles and bones, it can alleviate the patient's ankylosing spondylitis symptoms, but the medicine of this invention has complicated prescriptions, large dosage, and high medication cost.

Method used

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  • Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating ankylosing spondylitis
  • Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating ankylosing spondylitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The Chinese medicine composition of Example 1 of the present invention is made up of the preparation raw material of following parts by weight:

[0051] 25 parts of mugwort leaves, 20 parts of Ligustrum lucidum, 18 parts of Gorgon, 19 parts of Schisandra, 18 parts of Scrophulariae, 15 parts of Paeoniae Alba, 12 parts of Ophiopogon japonicus, 10 parts of Shimangcao, 9 parts of Asparagus, 5 parts of sea octopus , motherwort 4 parts and licorice 6 parts.

[0052] The preparation method is as follows:

[0053] S1. Weigh the raw medicinal materials of various flavors, remove impurities respectively, wash, dry, slice and crush into coarse powder;

[0054] S2. Take Artemisia argyi leaf coarse powder, add 10 times the total weight of the coarse powder with ethanol with a volume fraction of 65%, microwave extraction for 12 minutes, the microwave power is 280W, the extraction temperature is 60°C, filter and retain the Artemisia argyi leaf residue, and the filtrate is concentrate...

Embodiment 2

[0060] Embodiment 2 of the present invention Chinese medicine composition is made up of the preparation raw material of following parts by weight:

[0061] 35 parts of mugwort leaves, 33 parts of Ligustrum lucidum, 30 parts of Gorgon, 25 parts of Schisandra, 20 parts of Scrophulariae, 18 parts of white peony, 18 parts of Ophiopogon japonicus, 15 parts of Shimangcao, 13 parts of asparagus, 13 parts of sea octopus , 9 parts of motherwort and 16 parts of licorice.

[0062] The preparation method is the same as in Example 1.

Embodiment 3

[0064] Embodiment 3 of the present invention Chinese medicine composition is made up of the preparation raw material of following parts by weight:

[0065] 30 parts of mugwort leaf, 26 parts of Ligustrum lucidum, 24 parts of Gorgon, 22 parts of Schisandra, 19 parts of Scrophulariae, 17 parts of white peony root, 15 parts of Ophiopogon japonicus, 13 parts of Shimangcao, 11 parts of asparagus, 9 parts of sea octopus , 7 parts of motherwort and 11 parts of licorice.

[0066] The preparation method is the same as in Example 1.

[0067] Clinical curative effect observation of Chinese medicine composition of the present invention on ankylosing spondylitis clinical patient volunteers

[0068] 1. Basic information

[0069] A total of 120 clinical volunteer patients with ankylosing spondylitis who were treated in a hospital in Guangdong Province from March 2013 to April 2015 were selected, aged 25-45 years, with an average age of 28 years; the course of disease was 8 months to 15 yea...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition containing folium artemisiae argyi and used for treating ankylosing spondylitis. The traditional Chinese medicine composition comprises folium artemisiae argyi, ligustrum lucidum ait, semen euryales, fructus schizandrae, radix scrophulariae, radix paeoniae alba, radix ophiopogonis, Polygonum capitatum Buch, asparagus cochinchinensis, ossa sepiae, herba leonuri and radix glycyrrhizae. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is made of pure natural Chinese herbal medicine materials, is reasonable in proportion and distinctive in main and auxiliary materials, combines recuperating and treatment, and has good effects of dispelling wind and eliminating dampness, activating collaterals and alleviating pain, promoting blood circulation to remove blood stasis and strengthening tendons and bones; clinical experiments prove that the traditional Chinese medicine composition can effectively improve various indexes such as BADAI, BASFI, BASMI, spine pain and night pain of a patient and is low in cost, stable in medicine effect, convenient to take, good in curative effect, high in cure rate and free of side effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition containing mugwort leaves for treating ankylosing spondylitis. Background technique [0002] Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly invades sacroiliac joints, spinal condyles, paraspinal soft tissues and peripheral joints, and may be accompanied by extra-articular manifestations. The main clinical manifestations are waist, back, neck, buttock, hip pain and joint swelling and pain. In severe cases, spinal deformity and joint ankylosis may occur. The disease is also known as Marie-strümpell disease, Von Bechterew disease, rheumatoid spondylitis, spondylitis deformans, rheumatoid central type, etc., and is now called AS. The disease is generally negative for rheumatoid factor, so it is a seronegative spondylopathy with Reiter syndrome, psoriatic arthritis, and enteropathic arthritis. ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P19/00A61P29/00A61K35/618
CPCA61K36/8968A61K35/618A61K36/282A61K36/484A61K36/533A61K36/57A61K36/62A61K36/638A61K36/65A61K36/704A61K36/71A61K36/79A61K36/808A61K36/8965A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 王一飞吴国宪罗帆
Owner GUANGZHOU SANDE MEDICAL TECH CO LTD
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