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Beriberi treatment drug containing lysozyme

A technology of lysozyme and drugs, which is applied in the direction of drug combination, drug delivery, medical preparations containing active ingredients, etc., to achieve the effects of reasonable compatibility, treatment of beriberi, and simple preparation methods

Pending Publication Date: 2016-06-22
ZHEJIANG AEGIS BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] At present, the application of combining lysozyme and curcumin for the prevention and treatment of beriberi has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, prepare the ointment containing curcumin

[0038] The curcumin of 10 weight parts, the sodium carboxymethylcellulose of 50 weight parts, the zinc oxide of 10 weight parts and the disodium edetate of 1 weight part are dispersed in the purified water of 500 weight parts, stir to obtain water phase; then weigh 50 parts by weight of vaseline, put 10 parts by weight of Tween 80 in another container, and mix to obtain an oil phase; heat the water phase and the oil phase respectively, mix them, homogenize for 10 minutes, and prepare Become the ointment A1 that contains curcumin.

Embodiment 2

[0039] Embodiment 2, prepare the ointment containing lysozyme

[0040] Weigh 10 parts by weight of lysozyme, 50 parts by weight of sodium carboxymethylcellulose, 10 parts by weight of zinc oxide and 1 part by weight of disodium ethylenediamine tetraacetate and disperse them in 500 parts by weight of purified water, and stir to obtain water phase; then weigh 50 parts by weight of vaseline, put 10 parts by weight of Tween 80 in another container, and mix to obtain an oil phase; heat the water phase and the oil phase respectively, mix them, homogenize for 10 minutes, and prepare into ointment A2 containing lysozyme.

Embodiment 3

[0041] Embodiment 3, prepare the ointment containing lysozyme and curcumin (1:1)

[0042]Weigh 5 parts by weight of lysozyme, 5 parts by weight of curcumin, 50 parts by weight of sodium carboxymethylcellulose, 10 parts by weight of zinc oxide and 1 part by weight of disodium edetate dispersed in 500 parts by weight In purified water, stir evenly to obtain the water phase; then weigh 50 parts by weight of vaseline, and put 10 parts by weight of Tween 80 in another container, and mix to obtain the oil phase; heat the water phase and the oil phase respectively and mix them, After 10 minutes of qualitative transformation, the ointment A3 containing lysozyme and curcumin (1:1 by weight) was made after cooling.

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Abstract

The invention relates to pharmaceutical composition for treating beriberi. An active ingredient lysozyme and an active ingredient curcumin in the pharmaceutical composition are in a weight ratio being (1:10)-(10:1). Compared with a common Western medicine preparation, the lysozyme preparation adopts a simple preparation method, the compatibility of medicines is reasonable, the two active ingredients can produce synergistic interaction while respective functions are performed, and beriberi is treated remarkably. The lysozyme and the curcumin are naturally sourced, are safe and have no toxic and side effects; the pharmaceutical composition is free of an ingredient of a Western medicine antibacterial agent, so that the drug does not have drug resistance.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a medicine for treating beriberi. Background technique [0002] Athlete's foot is also called "tinea pedis" in medicine, commonly known as "Hong Kong's foot", which is a fungal infection of the foot. It manifests as itching, erythema, papules, peeling, or blisters between the toes or on the soles of the feet, which can erode and ooze in severe cases. If it is not controlled in time, it will spread to other parts, causing tinea corporis, jock itch or "onychomycosis". In medicine, beriberi is usually divided into three types: erosive, vesicular, and keratotic beriberi. The erosive type occurs between the third and fourth, fourth and fifth toes. At the beginning, the toes are wet, impregnated and whitish or have small blisters. After drying and desquamation, peeling off the dander becomes a moist, flushed, erosive surface, which is extremely itchy and prone to secondary infection. The ve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61P17/00A61P31/10A61K31/12
CPCA61K9/0014A61K9/06A61K31/12A61K38/47A61K47/06A61K2300/00
Inventor 潘宏涛卢亚萍
Owner ZHEJIANG AEGIS BIOLOGICAL SCI & TECH CO LTD
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