A kind of phenol theophyllic acid and its preparation method and application
A technology of phenol theophyllic acid and dihydromyricetin, applied in organic chemistry, nervous system diseases, drug combination, etc., can solve the problems of increasing gastrointestinal tract damage and failing to improve patients' mild cognitive impairment and cognitive function
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Embodiment 1
[0093] Synthesized five millimoles (5 mmol, 1.6 g) of dihydromyricetin were added to 20 ml of methanol and dissolved for 30 minutes, and the dissolved solution was placed in an ice bath. Use 5.5 mmol of piperidine (0.47 g / L), titrate into dihydromyricetin methanol solution in the presence of argon at -10°C, and let it stand for 20 minutes to make the reaction complete. Then, the reaction solution was concentrated under low pressure (vacuumizing to reduce the air pressure by about 20%), filtered, and washed three times with methanol to obtain phenotheophyllic acid (~2g).
Embodiment 2
[0095] 500 grams of dihydromyricetin was added to 6.25 liters of methanol to dissolve for 30 minutes, and the dissolved solution was placed in an ice tank. Use 103.8 g / L of piperidine to titrate into dihydromyricetin methanol solution in the presence of argon at -10°C, and let it stand for 20 minutes to make the reaction complete. Then, the reaction solution was concentrated under low pressure (vacuumizing to reduce the air pressure by about 20%), filtered, and washed three times with methanol to obtain phenol-theophyllic acid (about 625 grams).
Embodiment 3
[0097] 5000 grams of dihydromyricetin was added to 62.5 liters of methanol to dissolve for 30 minutes, and the dissolved solution was placed in an ice tank. Use 1038 g / L of piperidine to titrate into dihydromyricetin methanol solution in the presence of argon at -10°C, and let it stand for 20 minutes to make the reaction complete. Then, the reaction solution was concentrated under low pressure (vacuumizing to reduce the air pressure by about 20%), filtered, and washed three times with methanol to obtain phenol-theophyllic acid (about 6250 grams).
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