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Application of clomethiazole as medicine for preventing and treating liver and esophageal disease

A technology of clomethiazole and liver disease, applied in the application field of drugs for the prevention and treatment of liver and esophageal diseases

Inactive Publication Date: 2016-07-20
乔海灵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although surgery can significantly prolong life and even long-term survival; at the same time, it can remove tumors, relieve eating obstruction, and restore normal diet, but the 5-year survival rate after surgery for early esophageal cancer is only 70% to 90%.

Method used

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  • Application of clomethiazole as medicine for preventing and treating liver and esophageal disease
  • Application of clomethiazole as medicine for preventing and treating liver and esophageal disease
  • Application of clomethiazole as medicine for preventing and treating liver and esophageal disease

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Embodiment Construction

[0018] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0019] 1. Human liver specimen collection

[0020] 1.1 Normal human liver

[0021] 83 cases of normal human liver samples were clinically confirmed hepatic hemangioma, gallstone, hepatic cystadenoma, and gallbladder cancer. Healthy liver with normal liver histopathological examination. Immediately after surgical resection, they were stored in liquid nitrogen.

[0022] 1.2 Liver cirrhosis in patients with liver cancer

[0023] Cirrhotic liver samples from 93 patients with liver cancer were clinically confirmed HBV and / or HCV surface antigen positive primary liver cancer patients with liver cirrhosis who had surgically resected cirrhotic tissues > 2 cm from the tumor side. , the source of the liver should be pathologically examined and the fibrosis grade should re...

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Abstract

The invention discloses novel application of clomethiazole CMZ. Research findings show that the CMZ has the inhibiting effect on human cytochrome P4502E1(CYP2E1) metabolism nitrosamines compounds of dimethylinitrosamine DMN and Diethylinitrosamine DEN, and therefore clomethiazole can be used as a medicine for preventing and treating hepatic diseases such as hepatitis, hepatic fibrosis, cirrhosis and liver cancer and esophageal diseases such as ingluveosis phrenospasm, hiatal hernia, esophageal diverticula, esophagus polypus and papilloma and esophagus cancers.

Description

technical field [0001] The invention specifically relates to the application of clomethiazole as a medicine for preventing and treating liver and esophageal diseases. Background technique [0002] At present, cancer is one of the major diseases that seriously affect human health and threaten human life. Cancer, cardiovascular and cerebrovascular diseases and accidents are the three major causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world: one is to use surgical resection to remove the diseased tissue to prevent the spread of cancer cells; the other is to use radiotherapy to kill cancer cells; the third is to use drug therapy, namely chemotherapy, to kill cancer cells. or suppress cancer cells. Adopt surgical resection method to treat, increase patient's misery, hurt...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61P1/16A61P1/00A61P29/00A61P35/00
CPCA61K31/426
Inventor 乔海灵高洁
Owner 乔海灵
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