Polymer combined adjuvant of animal vaccine and applications thereof
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A technology of polymers and synthetic polymers, applied in drug combinations, vaccines, veterinary vaccines, etc., can solve problems such as tissue inflammatory response, poor immune effect, and animal fever and discomfort, and achieve broad application prospects and easy product process The effect of quality control
Active Publication Date: 2016-08-03
CHINA ANIMAL HUSBANDRY IND
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As a common adjuvant in veterinary biological products, oil adjuvants are mineral oils derived from the petroleum i...
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Embodiment 1
[0055] Example 1 is used to illustrate the polymer combination adjuvant of the present invention.
[0056] Composition and mass percentage are as follows:
[0068] Example 2 is used to illustrate the polymer combination adjuvant of the present invention.
[0069] Composition and mass percentage are as follows:
[0070] 1. 99.9% aqueous solution for injection;
[0071] 2. Polymer combination:
[0072] Carboxymethylcellulose 0.05%;
[0073] Polylactide-glycolide (PLCG) 0.05%.
Embodiment 3
[0075] Example 3 is used to illustrate the polymer combination adjuvant of the present invention.
[0076] Composition and mass percentage are as follows:
[0077] 1. 94% aqueous solution for injection;
[0078] 2. Polymer combination:
[0079] Mannan 2%;
[0080] Polyhydroxybutyrate (PHB) 1%;
[0081] Polyethylene glycol 80001%;
[0082] 3. Emulsifier:
[0083] Polyglycerol fatty acid ester 1%;
[0084] 4. Additives:
[0085] Propylene Glycol 1%.
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Abstract
The invention relates to vaccine adjuvant, and specifically discloses a polymer combined adjuvant of animal vaccine and applications thereof. The polymer combined adjuvant comprises an injection water solution, polymer, an emulsifier, and auxiliary agents. The provided polymer combined adjuvant is stable and efficient. Compared with the known vaccine adjuvant, the provided adjuvant has the characteristics of safety and efficiency, the product technology and quality can be controlled easily, and thus the adjuvant has a wide application prospect. The provided polymer combined adjuvant can be applied to industrial production of vaccine easily. The used polymer can be water solution or suspension liquid that can form a particle structure such as capsule or micelle. The antigen for preparing vaccine can be wrapped and stored into cavities formed by polymer or can also be evenly absorbed by polymer so as to be evenly distributed in the polymer.
Description
technical field [0001] The invention relates to a vaccine adjuvant, in particular to a polymer combination adjuvant for an animal vaccine and its application. Background technique [0002] An adjuvant refers to a substance that can be applied simultaneously or in advance with an antigen to enhance the body's immune response to the antigen, or to change the type of immune response. Adjuvants play a vital role in vaccines. They can act on both antigens and the body. Appropriate use of adjuvants can regulate or even change the type of antigen-specific humoral and / or cellular immune responses produced by the body's immune system. [0003] The mechanism of action of the adjuvant is consistent with the immune response process of the body. First, antigen-presenting cells are activated, foreign antigens are taken up, processed and presented, and then T cells and B cells are further activated. Through the fine adjustment of the cytokine network, the composition of the adjuvant can be...
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