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Polymer combined adjuvant of animal vaccine and applications thereof

A technology of polymers and synthetic polymers, applied in drug combinations, vaccines, veterinary vaccines, etc., can solve problems such as tissue inflammatory response, poor immune effect, and animal fever and discomfort, and achieve broad application prospects and easy product process The effect of quality control

Active Publication Date: 2016-08-03
CHINA ANIMAL HUSBANDRY IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a common adjuvant in veterinary biological products, oil adjuvants are mineral oils derived from the petroleum industry. Reactions, side effects such as fever and discomfort in animals, resulting in poor immune effect or even failure

Method used

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  • Polymer combined adjuvant of animal vaccine and applications thereof
  • Polymer combined adjuvant of animal vaccine and applications thereof
  • Polymer combined adjuvant of animal vaccine and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 is used to illustrate the polymer combination adjuvant of the present invention.

[0056] Composition and mass percentage are as follows:

[0057] 1. 90% aqueous solution for injection;

[0058] 2. Polymer combination:

[0059] Polyvinylpyrrolidone 2%;

[0060] Polylactic-glycolic acid (PLGA) 3%;

[0061] Polyethylene glycol 60001%;

[0062] 3. Emulsifier:

[0063] Alkyl glucoside (decyl glucoside) (APG0816) 2%;

[0064] Polyoxyethylene sorbitan monooleate 1%;

[0065] 4. Additives:

[0066] Cetyl Alcohol 1%.

Embodiment 2

[0068] Example 2 is used to illustrate the polymer combination adjuvant of the present invention.

[0069] Composition and mass percentage are as follows:

[0070] 1. 99.9% aqueous solution for injection;

[0071] 2. Polymer combination:

[0072] Carboxymethylcellulose 0.05%;

[0073] Polylactide-glycolide (PLCG) 0.05%.

Embodiment 3

[0075] Example 3 is used to illustrate the polymer combination adjuvant of the present invention.

[0076] Composition and mass percentage are as follows:

[0077] 1. 94% aqueous solution for injection;

[0078] 2. Polymer combination:

[0079] Mannan 2%;

[0080] Polyhydroxybutyrate (PHB) 1%;

[0081] Polyethylene glycol 80001%;

[0082] 3. Emulsifier:

[0083] Polyglycerol fatty acid ester 1%;

[0084] 4. Additives:

[0085] Propylene Glycol 1%.

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PUM

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Abstract

The invention relates to vaccine adjuvant, and specifically discloses a polymer combined adjuvant of animal vaccine and applications thereof. The polymer combined adjuvant comprises an injection water solution, polymer, an emulsifier, and auxiliary agents. The provided polymer combined adjuvant is stable and efficient. Compared with the known vaccine adjuvant, the provided adjuvant has the characteristics of safety and efficiency, the product technology and quality can be controlled easily, and thus the adjuvant has a wide application prospect. The provided polymer combined adjuvant can be applied to industrial production of vaccine easily. The used polymer can be water solution or suspension liquid that can form a particle structure such as capsule or micelle. The antigen for preparing vaccine can be wrapped and stored into cavities formed by polymer or can also be evenly absorbed by polymer so as to be evenly distributed in the polymer.

Description

technical field [0001] The invention relates to a vaccine adjuvant, in particular to a polymer combination adjuvant for an animal vaccine and its application. Background technique [0002] An adjuvant refers to a substance that can be applied simultaneously or in advance with an antigen to enhance the body's immune response to the antigen, or to change the type of immune response. Adjuvants play a vital role in vaccines. They can act on both antigens and the body. Appropriate use of adjuvants can regulate or even change the type of antigen-specific humoral and / or cellular immune responses produced by the body's immune system. [0003] The mechanism of action of the adjuvant is consistent with the immune response process of the body. First, antigen-presenting cells are activated, foreign antigens are taken up, processed and presented, and then T cells and B cells are further activated. Through the fine adjustment of the cytokine network, the composition of the adjuvant can be...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61P37/04
CPCA61K39/39A61K2039/552A61K2039/55511A61K2039/55583
Inventor 潘京学潘春刚王贺民刘兆环杨小蓉
Owner CHINA ANIMAL HUSBANDRY IND
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