Method for Determination of Specific Migration of Four Kinds of Aniline Derivatives by Liquid Chromatography

Abstract

The invention provides a method for liquid chromatography-mass spectrometry determination of the specific migration amount of 4 aniline-like derivatives; the 4 aniline-like derivatives are specifically derived from plastic food packaging materials and containers and respectively comprise 1,3-benzenedimethylamine, N-(4-hydroxyphenyl)acetamide, 4,4-diamino diphenyl sulfone and 1,3-diphenyl-2-thiourea. Through high performance liquid chromatography-tandem mass spectrometry, the specific migration amount of 4 aniline-like derivatives of 1,3-benzenedimethylamine, N-(4-hydroxyphenyl)acetamide, 4,4-diamino diphenyl sulfone and 1,3-diphenyl-2-thiourea can be efficiently, simply and rapidly determined, chromatographic separation and linear relationship are good, the recovery rate and the accuracy are high, and the quantity limitation requirements of European Union regulations are fully satisfied. The method is reasonable, has sensitive, accurate, rapid and convenient characteristics, and solves the problems of detection of the specific migration amount of the 4 harmful aniline-like derivatives in the plastic food packaging materials and containers.

Description

technical field [0001] The invention belongs to the field of chemical detection, and relates to the determination of aniline derivatives in food contact materials, in particular to a method for determining the specific migration of four aniline derivatives by liquid chromatography-mass spectrometry, the four aniline derivatives It is m-xylylenediamine (cas: 1477-55-0), N-(4-hydroxyphenyl) acetamide (cas: 103-90-2), 4,4-diaminodiphenyl sulfone (cas: 80 -08-0) and 1,3-diphenyl-2-thiourea (cas: 102-08-9). technical background [0002] m-Xylylenediamine (cas: 1477-55-0), N-(4-hydroxyphenyl) acetamide (cas: 103-90-2), 4,4-diaminodiphenylsulfone (cas: 80- 08-0) and 1,3-diphenyl-2-thiourea (cas: 102-08-9), these four aniline derivatives are often used as resin raw materials, thermal stabilizers, curing agent functional additives, widely It is used in the production of polyurethane, xylene nylon resin, epoxy resin, polyvinyl chloride and other plastics. The residual or degraded a...

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Problems solved by technology

[0003] At present, there are four kinds of anilines related to m-xylylenediamine, N-(4-hydroxyphenyl)acetamide, 4,4-diaminodiphenylsulfone and 1,3-diphenyl-2-thiourea at home and abroad. The research on derivatives mainly focuses on the synthesis, production and application of these four compounds, while related m-xylylenediamine, N-(4-hydroxyphenyl)acetamide, 4,4-diaminodiphenyl sulfone and 1 , 3-diphenyl-2-thiourea, the detection of the specific migration of the four aniline derivatives, there is no relevant research report

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