Strong loquat leaf extract refined with honey, preparation method of strong loquat leaf extract and application of strong loquat leaf extract

A loquat paste, strong technology, applied in separation methods, chemical instruments and methods, ointment transportation, etc., can solve problems such as affecting application, many impurities, and rough process.

Inactive Publication Date: 2016-11-23
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the prior art, the extraction method of honey-refined strong loquat extract has a rough and backward process, many impurities, and low active ing

Method used

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  • Strong loquat leaf extract refined with honey, preparation method of strong loquat leaf extract and application of strong loquat leaf extract
  • Strong loquat leaf extract refined with honey, preparation method of strong loquat leaf extract and application of strong loquat leaf extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 69g of loquat leaves, 15g of Baibu, 6g of Morus alba cortex, 50g of poppy shell, 9g of Baiqian, 6g of bellflower, 0.15g of menthol, add 10 times the weight of water to other medicinal materials except menthol, soak for 0.5h, and decoct After 1 hour, filter, add water with 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60 °C and the relative density is 1.05, add ethanol to make the volume of the alcohol content When the percentage reaches 75%, stir, stand still, filter, and the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and the ethanol is recovered to obtain a concentrated solution, and supercritical extraction is used to obtain a supercritical extract, which is further concentrated to about 100ml and added with benzene Sodium formate 2.5g, stir to dissolve, add about 100ml of refined honey, 300ml of maltose, continue...

Embodiment 2

[0021] Take 69g of loquat leaves, 15g of Baibu, 6g of Morus alba cortex, 50g of poppy shell, 9g of Baiqian, 6g of bellflower, 0.15g of menthol, add 10 times the weight of water to other medicinal materials except menthol, soak for 0.5h, and decoct After 1 hour, filter, add water with 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60 °C and the relative density is 1.05, add ethanol to make the volume of the alcohol content When the percentage reaches 75%, stir, stand still, filter, and the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and the ethanol is recovered to obtain a concentrated solution, and supercritical extraction is used to obtain a supercritical extract, which is further concentrated to about 100ml and added with benzene Sodium formate 2.5g, stir to dissolve, add about 100ml of refined honey, 300ml of maltose, continue...

Embodiment 3

[0025] Take 69g of loquat leaves, 15g of Baibu, 6g of Morus alba cortex, 50g of poppy shell, 9g of Baiqian, 6g of bellflower, 0.15g of menthol, add 10 times the weight of water to other medicinal materials except menthol, soak for 0.5h, and decoct After 1 hour, filter, add water with 8 times the weight of medicinal materials to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine the two decoction liquids, concentrate to 60 °C and the relative density is 1.05, add ethanol to make the volume of the alcohol content When the percentage reaches 75%, stir, stand still, filter, and the relative density of the filtrate is 1.25 when the filtrate is concentrated to 65°C, and the ethanol is recovered to obtain a concentrated solution, and supercritical extraction is used to obtain a supercritical extract, which is further concentrated to about 100ml and added with benzene Sodium formate 2.5g, stir to dissolve, add about 100ml of refined honey, 300ml of maltose, continue...

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Abstract

The invention provides a strong loquat leaf extract refined with honey. The strong loquat leaf extract is prepared from 69g of loquat leaves, 15g of radix stemonae, 6g of root barks of white mulberry, 50g of poppy shells, 9g of cynanchum glaucescens, 6g of platycodon grandiflorum and 0.15g of menthol. The other medicinal materials except the menthol are subjected to extraction and alcohol sedimentation to obtain concentrated solution, supercritical extracts are obtained by supercritical extraction, concentration is continued to reach about 100ml, 2.5g of sodium benzoate is added and dissolved by stirring, about 100ml of processed honey and 300ml of maltose are added and heated to boil for 20 minutes, the solution is filtered and chilled, 0.5g of citric acid, the menthol and an appropriate amount of loquat essence dissolved by ethyl alcohol are added, stirred and uniformly mixed, and the processed honey is added to reach 100ml and uniformly mixed to obtain the strong loquat leaf extract refined with the honey. The platycodon D content of the prepared strong loquat leaf extract refined with the honey is high, and application of the strong loquat leaf extract refined with the honey to preparation of human embryo kidney HEK-293 cell proliferation inhibition medicines is discovered.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a honey-refined strong loquat extract and a preparation method and application thereof. Background technique [0002] In the prior art, the extraction method of honey-refined Qiangli loquat extract has a rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: In order to solve the above problems, the purpose of the present invention is to provide a kind of honey refining strong loquat extract and its preparation method and application. [0004] Technical scheme: the purpose of the present invention is achieved by the following scheme: [0005] A kind of honey refining strong loquat extract, the preparation method is: take 69...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61P43/00A61K31/045B01D11/02
CPCA61K9/06A61K31/045A61K36/27A61K36/346A61K36/605A61K36/66A61K36/73A61K36/904A61K47/46A61K2236/331A61K2236/39A61K2236/51A61K2236/53B01D11/0203A61K2300/00
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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