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Bitter melon extract and application of extract in reduction of N-nitrosamine compound in cigarette smoke

A technology for extracts and compounds of bitter gourd, which is applied in tobacco, application, gas treatment and other directions, can solve the problems of small amount of nitrosamine removal, potential safety hazards in industrial production and the like

Inactive Publication Date: 2016-12-07
CHINA TOBACCO FUJIAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have a small amount of removal of tobacco-specific nitrosamines and there are potential safety hazards in industrial production.

Method used

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  • Bitter melon extract and application of extract in reduction of N-nitrosamine compound in cigarette smoke
  • Bitter melon extract and application of extract in reduction of N-nitrosamine compound in cigarette smoke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 bitter gourd extract

[0030] After slicing, drying and crushing bitter gourd, degreasing with ether, passing through a 40-mesh sieve to obtain bitter gourd powder, then ultrasonically extracting bitter gourd powder in 70% ethanol at 50°C and ultrasonic power of 108W for 40-50min, the volume of bitter gourd powder and volume The mass ratio of 70% ethanol is 1:14, filtered, the filtrate is concentrated, extracted with n-butanol, dried and concentrated to obtain bitter melon extract as a brown oil.

[0031] After testing, the bitter melon extract is mainly composed of saponins and acidic components, and its main components are Momordicoside F1 (Momordicoside FI), Momordicoside I (Momordicoside I), Momordicoside G (Momordicoside G), and Momordicoside A (Momordicoside A) , Momordicoside B (Momordicoside B), Momordica, licic acid, butyric acid, palmitic acid, stearic acid, lauric acid, linoleic acid, myristic acid, linolenic acid, etc. attach...

Embodiment 2

[0041] Slowly inject the bitter melon extract prepared in Example 1 into the middle of the cigarette filter core from the inside to the outside, and the addition amount is 5 mg; carry out simulated smoking in a cigarette machine with an untreated sample; use liquid chromatography tandem mass spectrometry to determine the mainstream of the cigarette NNK content in flue gas.

[0042] Attached Table 1 Comparison of the effects of reducing NNK in mainstream smoke

[0043] Addition of Bitter Melon Extract

Embodiment 3

[0045] Slowly inject the bitter melon extract prepared in Example 1 into the middle of the cigarette filter core from the inside to the outside, and the addition amount is 10 mg; carry out simulated smoking with a cigarette machine with untreated samples; use liquid chromatography tandem mass spectrometry to determine the mainstream NNK content in flue gas.

[0046] Attached Table 2 Comparison of the Effects of Reducing NNK in Mainstream Smoke

[0047] Addition of Bitter Melon Extract

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Abstract

The invention relates to a bitter melon extract and application of the extract in reduction of an N-nitrosamine compound in cigarette smoke. Specifically, a preparation method of the bitter melon extract comprises the following steps that 1, bitter melons are subjected to ultrasonic extraction in an alcohols solvent, and filtration and filtrate collection are performed; 2, the filtrate collected in the step 1 is concentrated and extracted, an organic phase is collected, dried and concentrated to obtain the bitter melon extract. The content of the nitrosamine compound in a main smoke flow can be reduced, the bitter melon extract can coordinate with the cigarette smoke to improve the sweet aftertaste of the smoke.

Description

technical field [0001] The invention relates to the field of cigarette harm reduction, in particular to a bitter gourd extract, a preparation method thereof, and an application thereof in reducing N-nitrosamine compounds in cigarette smoke. Background technique [0002] Epidemiological surveys show that smoking can cause lung, bronchial, oral and other diseases in humans. The main pathogenic factors in tobacco and smoke are polycyclic aromatic hydrocarbons, nitrosamines, etc. Among them, tobacco-specific N-nitrosamines (tobacco-specific N-nitrosamines, TSNAs) are demethylated by N-nitroso Nicotine (NNN), N-nitrosoanabatin (NAB), N-nitrosoanatabine (NAT) and 4-(N-methyl-N-nitrosamine)-1-(3 -pyridyl)-butanone (NNK)-based. This is a class of N-nitrosamine compounds that only exist in tobacco and smoke. It is an organ-specific carcinogen with strong carcinogenicity. Its main target organ is the lung tissue. It plays a very important role in the pathogenesis of disease, thus b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24D3/14A24B15/10B01D53/02
CPCA24D3/14A24B15/10B01D53/02B01D2257/40
Inventor 谢卫刘泽春邓其馨叶仲力黄朝章黄华发张建平吴清辉黄延俊林艳张廷贵方钲中
Owner CHINA TOBACCO FUJIAN IND
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