Composition having immunoregulatory activity as well as preparation and application thereof

A technology of immunomodulatory activity and composition, applied in the field of compositions with immunomodulatory activity, can solve problems such as unreported

Inactive Publication Date: 2017-01-11
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the immunomodulatory effect of a composition compos

Method used

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  • Composition having immunoregulatory activity as well as preparation and application thereof
  • Composition having immunoregulatory activity as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1

[0021] Weigh 100 g of Artemisia japonica coarse powder and 100 g of oyster shell coarse powder. After mixing, add water according to the weight-to-volume ratio of the material solution of 1 g: 12 mL, soak at room temperature for 0.5 h, decoct and extract in water for 2.5 h; filter the extract while hot with 8 layers of gauze, The filtrate was centrifuged at 5000 rpm for 20 minutes; the extraction step was repeated three times in total. The supernatants were combined and concentrated to dryness under reduced pressure to obtain composition 1.

[0022] The content of fucoidan in composition 1 was determined by HPLC-PMP derivatization method. Specifically: Weigh an appropriate amount of the composition, add water to dissolve to constant volume, prepare a solution of 10 mg / mL, accurately measure 100 μL, add 100 μL of 2M trifluoroacetic acid solution, mix well, N 2The tube was sealed under protection, degraded at 100 °C for 5 h, cooled, added with 200 μL of meth...

Example Embodiment

[0023] Example 2

[0024] Weigh 100 g of hijiki coarse powder, add 95% ethanol according to the weight-to-volume ratio of hijiki and 70% ethanol 1 g:8 mL, soak at room temperature for 24 hours; filter to obtain defatted hijiki coarse powder, and dry. Weigh 20 g of oyster shell coarse powder and mix it with the defatted hijiki; add a hydrochloric acid solution with pH 3.5 in a weight-to-volume ratio of 1 g: 12 mL, soak at room temperature for 0.5 h, and extract at 100 °C for 2 h; the extract is hot with 8 layers of gauze After filtration, the filtrate was centrifuged at 5000 rpm for 20 minutes; the extraction was repeated twice in total. The supernatants were combined and concentrated to dryness under reduced pressure to obtain composition 2. The fucoidan content of Composition 2 was found to be 3.84%.

Example Embodiment

[0025] Example 3

[0026] Weigh 100 g of hijiki coarse powder, according to the hijiki and solvent (CH 3 OH:CH 2 Cl 2 : H 2 O=4:2:1) in a weight-to-volume ratio of 1g:8mL, add a solvent, soak at room temperature for 24h; filter to obtain degreasing hijiki coarse powder, and dry. Weigh 50 g of oyster shell coarse powder and mix it with defatted hijiki; add water at a weight-to-volume ratio of 1 g to 12 mL of the material solution, soak at room temperature for 0.5 h, and extract at 100 °C for 2.5 h; the extract is filtered with 8 layers of gauze while it is still hot, and the filtrate is 5000 rpm. Centrifuge for 20 minutes; repeat the extraction step 3 times. The supernatants were combined and concentrated to dryness under reduced pressure to obtain composition 3. The fucoidan content of Composition 3 was found to be 3.62%.

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Abstract

The invention provides composition having an immunoregulatory activity, as well as a preparation and an application thereof. The composition comprises an active ingredient and optional auxiliary materials, and is characterized in that the active ingredient comprises seaweed or defatted seaweed and oyster shells or comprises an extract from extraction of the seaweed or defatted seaweed and the oyster shells. The seaweed and oyster shell composition has the technical effect of synergistic interaction on the effect of improving immunocompetence.

Description

technical field [0001] The present invention relates to a composition with immunoregulatory activity, its preparation method and application. Background technique [0002] Immunity is the body's own defense mechanism, which is the body's ability to recognize and eliminate any foreign matter (viruses, bacteria, etc.) . When the immune function of the human body is reduced or out of balance, the immune system cannot normally play a protective role in the body, thus causing diseases. [0003] Seaweed is the type with the largest number and variety of marine plants. Polysaccharide is its main component, which has the functions of enhancing the body's immune activity, anti-virus, anti-tumor, anti-oxidation, and anti-radiation; a large number of research results show that seaweed polysaccharide is through a variety of mechanisms. These functions are performed by activating the immune system and improving the body's specific and / or non-specific immune function. Its immune regula...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P37/04A61P35/00A23L33/105A23L33/10A61K35/618
CPCA61K36/03A23V2002/00A61K35/618A61K2300/00A23V2200/324A23V2200/308A23V2250/202A23V2250/2042
Inventor 刘红兵管华诗胡淑曼付志飞
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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