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Composition having immunoregulatory activity as well as preparation and application thereof

A technology of immunomodulatory activity and composition, applied in the field of compositions with immunomodulatory activity, can solve problems such as unreported

Inactive Publication Date: 2017-01-11
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the immunomodulatory effect of a composition composed of seaweed and oyster shells has not been reported so far

Method used

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  • Composition having immunoregulatory activity as well as preparation and application thereof
  • Composition having immunoregulatory activity as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 100g of sea wormwood coarse powder and 100g of oyster shell coarse powder. After mixing, add water according to the weight-to-volume ratio of material to liquid: 1g: 12mL, soak at room temperature for 0.5h, decoct and extract in water for 2.5h; filter the extract with 8 layers of gauze while it is hot, The filtrate was centrifuged at 5000 rpm for 20 minutes; the extraction step was repeated for a total of 3 times. The supernatants were combined, concentrated and dried under reduced pressure to obtain composition 1.

[0022] The content of fucoidan in composition 1 was determined by HPLC-PMP derivatization method. Specifically: Weigh an appropriate amount of the composition, add water to dissolve to a constant volume, and prepare a 10 mg / mL solution, accurately measure 100 μL, add 100 μL of 2M trifluoroacetic acid solution, mix well, N 2Seal the tube under protection, degrade at 100°C for 5 hours, cool, add 200 μL of methanol, blow dry with nitrogen at 35°C, add m...

Embodiment 2

[0024] Weigh 100 g of hijiki coarse powder, add 95% ethanol according to the weight volume ratio of hijiki and 70% ethanol 1g:8mL, soak at room temperature for 24 hours; filter to obtain defatted hijiki coarse powder, and dry. Weigh 20g of coarse oyster shell powder and mix it with defatted hijiki; according to the weight-to-volume ratio of material to liquid 1g: 12mL, add hydrochloric acid aqueous solution with pH 3.5, soak at room temperature for 0.5h, and extract at 100°C for 2h; extract the solution while hot with 8 layers of gauze Filter, and centrifuge the filtrate at 5000 rpm for 20 minutes; repeat the extraction twice in total. The supernatants were combined, concentrated and dried under reduced pressure to obtain composition 2. The fucoidan content of Composition 2 was measured to be 3.84%.

Embodiment 3

[0026] Take by weighing hijiki coarse powder 100g, according to hijiki and solvent (CH 3 OH:CH 2 Cl 2 :H 2 (0=4:2:1) with a weight-to-volume ratio of 1g:8mL, adding a solvent, soaking at room temperature for 24 hours; filtering to obtain degreased hijiki coarse powder, and drying. Weigh 50g of coarse oyster shell powder and mix it with defatted hijiki; add water according to the weight-to-volume ratio of material to liquid: 1g: 12mL, soak at room temperature for 0.5h, and extract at 100°C for 2.5h; filter the extract while hot with 8 layers of gauze, and the filtrate is 5000rpm Centrifuge for 20 minutes; repeat the extraction step a total of 3 times. The supernatants were combined, concentrated and dried under reduced pressure to obtain composition 3. The fucoidan content of Composition 3 was measured to be 3.62%.

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Abstract

The invention provides composition having an immunoregulatory activity, as well as a preparation and an application thereof. The composition comprises an active ingredient and optional auxiliary materials, and is characterized in that the active ingredient comprises seaweed or defatted seaweed and oyster shells or comprises an extract from extraction of the seaweed or defatted seaweed and the oyster shells. The seaweed and oyster shell composition has the technical effect of synergistic interaction on the effect of improving immunocompetence.

Description

technical field [0001] The present invention relates to a composition with immunoregulatory activity, its preparation method and application. Background technique [0002] Immunity is the body's own defense mechanism, which is the body's ability to recognize and eliminate any foreign matter (viruses, bacteria, etc.) . When the immune function of the human body is reduced or out of balance, the immune system cannot normally play a protective role in the body, thus causing diseases. [0003] Seaweed is the type with the largest number and variety of marine plants. Polysaccharide is its main component, which has the functions of enhancing the body's immune activity, anti-virus, anti-tumor, anti-oxidation, and anti-radiation; a large number of research results show that seaweed polysaccharide is through a variety of mechanisms. These functions are performed by activating the immune system and improving the body's specific and / or non-specific immune function. Its immune regula...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P37/04A61P35/00A23L33/105A23L33/10A61K35/618
CPCA61K36/03A23V2002/00A61K35/618A61K2300/00A23V2200/324A23V2200/308A23V2250/202A23V2250/2042
Inventor 刘红兵管华诗胡淑曼付志飞
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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