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Panax notoginseng saponins sustained-release gel and preparation method thereof

A technology of panax notoginseng total saponins and slow-release gel, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor water solubility and limited application of chitosan, Achieve the effects of improving material properties, prolonging the action time, and solving poor mechanical properties

Inactive Publication Date: 2017-01-18
WENSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor water solubility of chitosan limits its application.

Method used

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  • Panax notoginseng saponins sustained-release gel and preparation method thereof
  • Panax notoginseng saponins sustained-release gel and preparation method thereof
  • Panax notoginseng saponins sustained-release gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a slow-release gel of Panax notoginseng saponins, characterized in that it is composed of the following raw materials by weight: carboxymethyl chitosan 56%, polyvinylpyrrolidone 16.6%, Panax notoginseng saponins 0.07% and Sodium trimetaphosphate 27.29%.

Embodiment 2

[0027] Embodiment 2: a slow-release gel of Panax notoginseng saponins, characterized in that it is composed of the following raw materials by weight: carboxymethyl chitosan 74%, polyvinylpyrrolidone 7.4%, Panax notoginseng saponins 0.11% and Sodium Trimetaphosphate 18.49%.

Embodiment 3

[0028] Embodiment 3: a slow-release gel of Panax notoginseng saponins, characterized in that it is composed of the following raw materials by weight: carboxymethyl chitosan 62.22%, polyvinylpyrrolidone 10%, Panax notoginseng saponins 0.08% and Sodium Trimetaphosphate 27.7%.

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Abstract

The invention relates to a panax notoginseng saponins sustained-release gel and a preparation method thereof and relates to the field of medicine health care. The panax notoginseng saponins sustained-release gel comprises, by weight ratio, 56-74% of carboxymehyl chitosan, 7.4-16.6% of polyvinylpyrrolidone, 0.07-0.11% of panax notoginseng saponins and 18.4-27.7% of coss-linking agent. The medicine release rate of panax notoginseng saponins is effectively controlled, the panax notoginseng saponins utilization rate is improved, metabolism dynamics properties of the medicine in the human body are improved, too high medicine concentration in blood is avoided, and a stable plasma concentration is provided, so as to achieve the objectives of prolonging action time of the medicine in the human body and reducing dosing times; toxic and side effects of the medicine can further be reduced, and patients' compliance is improved.

Description

technical field [0001] The present invention relates to the field of medicine and health care. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the number one killer of human health. They have the characteristics of "high morbidity, high disability rate, high mortality rate, high recurrence rate, and many complications", that is, "four highs and one high". Statistics show that there are currently more than 270 million patients with cardiovascular and cerebrovascular diseases in my country. With the development of society and the improvement of living standards, the Chinese people's lifestyle and diet structure have undergone tremendous changes. These lifestyles and risk factors will cause a rapid increase in the incidence of cardiovascular and cerebrovascular diseases. Medical experts at home and abroad have taken the treatment of cardiovascular and cerebrovascular diseases as an important research content. At present, western medicines f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61K36/258A61P9/10
CPCA61K9/0002A61K9/0014A61K9/06A61K36/258A61K47/32A61K47/36
Inventor 谭福能刘俊张志信徐怀春何媛媛
Owner WENSHAN UNIV
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