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Medical device including anionic drug

An ionic, medical technology, applied in the field of medical devices, can solve problems such as contact lens distortion, burden on the healer, allergies, etc., and achieve the effect of small shape change, effective treatment, and suppression of foreign body sensation

Active Publication Date: 2017-02-15
SEED CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in order to maintain the effective concentration of the drug, it is necessary to increase the drug content in the eye drops or to increase the frequency of using the eye drops, either of which imposes a great burden on the healer
[0006] In addition, when using drugs for patients who wear contact lenses, there may be adverse effects such as distorting or deteriorating the contact lenses, or the preservatives added to many eye drops sold on the market will be absorbed into the contact lenses, which may cause allergy risk
Therefore, drug therapy via eye drops is not suitable for patients wearing contact lenses

Method used

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  • Medical device including anionic drug
  • Medical device including anionic drug
  • Medical device including anionic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0083] [Preparation of Examples (1) to (8)]

[0084] In a mixture containing 2-hydroxyethyl methacrylate (HEMA) and methacryloyloxyethyldimethylbenzyl ammonium chloride (MOEBAC) at a ratio corresponding to 1 mole of HEMA shown in Table 1 below, In the mixture, add polyethylene glycol diacrylate (A-200) of 1 mol% of the total mole of monomers and azobisisobutyronitrile (AIBN) of 3000ppm (outside) of the total mole of monomers, stir and mix to obtain Monomer mixture. The resulting monomer mixture was poured into a molding die, and the temperature was raised in the range of 30 to 110° C. for 17 hours to carry out a copolymerization reaction to obtain a copolymer. Return the obtained copolymer to room temperature, take it out from the mold, and then immerse it in a phosphate buffer solution containing ethanol at 60°C for 1 hour each, and then immerse it in pure water at room temperature for 2 hours or more. A hydrated and swollen hydrogel is obtained. Gained hydrogel, in the de...

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Abstract

The purpose of the present invention is to provide a medical device including a drug, which is manufactured using a polymer gel that enables the increase in the amount of the drug to be included in the medical device compared with the conventional techniques, and which has reduced influence on gel strength and shape stability after the release of the drug. The purpose can be achieved by a medical device including an anionic drug, said medical device comprising: (1) an anionic drug; and (2) a copolymer which contains, as constituent components, a cationic monomer comprising a condensation product of an alkyl quaternary ammonium compound having a substituted or unsubstituted aralkyl group and (meth)acrylic acid or a salt of the condensation product and a monomer capable of copolymerizing with the condensation product or the salt of the condensation product.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS OF THE INVENTION [0002] This application claims the priority of Japanese Patent No. 2014-085664 for which it applied on April 17, 2014, and all description is used here as an indication. technical field [0003] The present invention relates to medical devices containing anionic drugs. Background technique [0004] Examples of therapeutic methods for ophthalmic diseases typified by glaucoma and dry eye include vitreous injections, insertion of lacrimal plugs, and drug therapy. Vitreous injection or insertion of a punctal plug is an invasive treatment, so it is accompanied by problems such as pain or foreign body sensation. In addition, in the case of drug therapy, there is a problem that the desired effect may not be obtained depending on the amount of the drug or the method of administration. Therefore, drug therapy with a therapeutic effect requires various attempts. [0005] When drug treatment is carried out by eye drop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/06A61K31/352A61K31/661A61P27/02
CPCA61K31/352A61K47/32A61K9/0051A61P27/02A61K31/573A61K9/06A61K31/661
Inventor 小畑晴香庄司洁山崎佳子松永透佐藤隆郎朝山和喜子安枝真一
Owner SEED CO LTD
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