Streptococcus equi subsp and production technology for preparing hyaluronic acid through streptococcus equi subsp

A technology of Streptococcus equi and hyaluronic acid, applied in bacteria, microorganisms, microorganisms, etc., can solve the problems such as the inability to stimulate the activity of bacteria, the low yield of hyaluronic acid, and the long fermentation period. The effect of high output rate and lower production cost

Active Publication Date: 2017-02-22
东营佛思特生物工程有限公司
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Problems solved by technology

[0002] At present, the process of producing hyaluronic acid by microbial fermentation has a long fermentation cycle, and the fermentation process cannot be carried out a

Method used

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Embodiment １

[0021] Streptococcus equi subsp. zooepidemicus ( Streptococcus equi subsp. zooepidemicus ) DCS005. At present, this Streptococcus equi subspecies zooepidemicus is preserved in the General Microbiology Center of the China Microbiological Culture Collection Management Committee. .12782, the Latin name for the strain is Streptococcus equi subsp. zooepidemicus , The reference microorganism (strain): DCS005, the date of preservation is July 14, 2016.

[0022] The production process for preparing hyaluronic acid with the described Streptococcus equi subspecies zooepidemicus comprises the following steps:

[0023] (1) Shake flask seed solution culture;

[0024] (2) Bacterial expansion and cultivation;

[0025] (3) Fermentation, first feed sterile oxygen-containing air to ferment, and then feed nitrogen to continue fermentation;

[0026] (4) Purification.

[0027] The culture solution in steps (1), (2), and (3) includes starch 1%, sucrose 0.5%, beef extract 0.5%, yeast powder 0.5...

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Abstract

The invention discloses a streptococcus equi subsp and a production technology for preparing hyaluronic acid through the streptococcus equi subsp. According to the novel screened streptococcus equi subsp, the improved fermentation technology is combined, the output rate of a hyaluronic acid product is high, and can be 9.5 g/L. The fermented streptococcus equi subsp is easy to separate and purify, and the production cycle is short; production is easy to control, the streptococcus equi subsp is suitable for industrial mass production, the yield is high, and the production cost is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid production, in particular to a Streptococcus equi subsp. Background technique [0002] At present, the process of producing hyaluronic acid by microbial fermentation has a long fermentation period, and the fermentation process cannot be carried out according to the characteristics of the strain, resulting in the inability to stimulate the activity of the strain, resulting in low hyaluronic acid yield and poor product quality. It is a technical problem to be solved in the present invention to develop new strains for fermentation and to improve the production process according to the characteristics of the strains to increase the quality and output of hyaluronic acid. Contents of the invention [0003] The object of the present invention is to provide a streptococcus equi subspecies zooepidemicus and a production process for preparing hyaluronic acid in view of the above-mentioned defects....

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P19/26C12R1/46
CPCC12P19/26C12N1/205C12R2001/46
Inventor 张振武朱连明肖馗缨惠贤秋马骞寰牛玲晓
Owner 东营佛思特生物工程有限公司
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