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A new feeding method of Ketering capsules

A new method, capsule technology, applied in the field of drug production and feeding process, can solve the problem of no theoretical basis for inter-batch mixing and feeding, and achieve the effect of improving the stability of results, significant innovation and technological progress, and improving the pass rate

Active Publication Date: 2020-02-14
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The contribution of the present invention lies in: the basis and method for establishing batch-mixed feeding with multiple indicators is proposed for the first time, which solves the difficult problem that there is no theoretical basis for batch-mixed feeding in the actual production process of Ketraling Capsules, and fills the gap where a single content measurement item is used as the basis for mixing. Indicators are technically deficient

Method used

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  • A new feeding method of Ketering capsules
  • A new feeding method of Ketering capsules
  • A new feeding method of Ketering capsules

Examples

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Embodiment example

[0027] Calculation Method of Dosing of Dry Extract of Ficus microphylla

[0028] Table 3 Calculation of Homogenization of Feeding of Ficus microphylla Dry Extract

[0029]

[0030] Taking a prescription quantity as an example, the formula for calculating the feed quantity X based on moisture is as follows:

[0031]

[0032] x 1 =X 处方量 (P 要求水分 -P 水分2 ) / (P 水分1 -P 水分2 )=360*(5.0-7.7) / (3.5-7.7)=231.42g

[0033] x 2 =X 处方量 (P 要求水分 -P 水分1 ) / (P 水分2 -P 水分1 )=360*(5.0-3.5) / (7.7-3.5)=128.58g

[0034] The calculation formula for calculating the feeding amount X based on the extract is as follows:

[0035]

[0036] x 3 =X 处方量 (P 要求浸出物 -P 浸出物2 ) / (P 浸出物1 -P 浸出物2 )=360*(60.0-69.0) / (58.0-69.0)=294.54g

[0037] x 4 =X 处方量 (P 要求浸出物 -P 浸出物1 ) / (P 浸出物2 -P 浸出物1 )=360*(60.0-58.0) / (69.0-58.0)=65.46g The calculation formula for calculating the feeding amount X based on content determination is as follows:

[0038]

[0039] x 5 =X 处方量 (P 要求含量测定 -P 含量测定2 ) / (P ...

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Abstract

A Keteling capsule is prepared from herba ficus dry extract and chlorpheniramine maleate. The invention discloses a novel feeding method of the Keteling capsule for the first time. The water content of the herba ficus dry extract, an extractive and a content determination item are taken as the indexes of uniform feeding, weights of detection items in a raw material quality standard are checked, and a raw material uniform feeding standard is made up by makeup of a calculation formula and industrial verification, thereby fulfilling the aim of achieving uniform and stable finished product quality and conforming to the requirements and concept of new-edition GMP (Good Manufacturing Practice). The prepared Keteling capsule has the effects of alleviating cough and asthma, diminishing inflammation and eliminating phlegm, and is used for treating cough with dyspnea and chronic bronchitis.

Description

technical field [0001] The invention relates to a new feeding method of Ketraling capsules, which belongs to the technical field of feeding technology for pharmaceutical production. Background technique [0002] Keteling Capsules is a compound preparation of traditional Chinese and western medicine recorded in the 2015 edition of "Chinese Pharmacopoeia". Ficus microphylla has antibacterial, analgesic, anti-inflammatory and anti-cough and anti-asthmatic effects. It mainly contains triterpenoids, flavonoids, acidic resins, tannins and other ingredients. It is often used clinically for the treatment of various diseases such as cough, asthma, and bronchitis. . The preparation method of the dry extract of Ficus xiaoye: dry the leaves of Ficus xiaoye, add water to decoct twice, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10-1.20 (80°C), let it cool, add ethanol to make The alcohol content reaches 60%, stand still for more...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/60A61K9/48A61P11/06A61P11/14A61P29/00A61P31/00G16C20/00A61K31/4402
CPCA61K9/48A61K31/4402A61K36/60G16C20/50A61K2300/00
Inventor 王美慧姜文月魏晓雨边雨徐杰周立梅苏婷
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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