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Hydrogel and preparation method and application of ampholytic hydrogel shaped body

A technology of hydrogel and formed body, which is applied in the field of hydrogel for detecting glucose concentration, can solve the problems of high detection limit, inaccurate detection concentration, harsh reaction conditions, etc., achieve low detection limit of urine sugar, simple production method, Measuring the precise effect of concentration

Active Publication Date: 2017-05-10
SUZHOU UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urine glucose test strips have many advantages such as convenient portability and stable color development. However, because the reaction is catalyzed by enzymes, the reaction conditions are relatively harsh and are limited by many external conditions.
In addition, the key problem is that the urine sugar test strip can only indirectly test the blood sugar reference value above 10mmol / L, the detection limit is high, and the detection concentration is not accurate

Method used

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  • Hydrogel and preparation method and application of ampholytic hydrogel shaped body
  • Hydrogel and preparation method and application of ampholytic hydrogel shaped body
  • Hydrogel and preparation method and application of ampholytic hydrogel shaped body

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of amphoteric hydrogel shaped body

[0044] 56mg of N-isopropylacrylamide (NIPAM), 19.1mg of 3-acrylamidophenylboronic acid (AAPBA), and 4.6mg of crosslinker N,N'-methylenebisacrylamide, 17.3mg of surface active Sodium dodecyl sulfate (SDS) was dissolved in 1mL dimethyl sulfoxide, ultrasonic 1min to form a mixed solution, then 2.7mg initiator azobisisobutylamidine hydrochloride and 20μL cross-linking agent N,N ,N',N'-Tetramethyldiethylamine was added to the mixed solution, after stirring for 2min, 10mg Fe 3 o 4 Nanoparticles were added to the mixed solution, and after ultrasonic oscillation for 2 min, N was passed into the mixed solution. 2 40min; then use a pipette to transfer the mixed solution into the fish-shaped template, as attached figure 1 As shown in Figure a-Figure B; after 2.5h of ultraviolet light irradiation, a copolymerization reaction occurs to generate a hydrogel, and then the hydrogel is released from the template (use tweezers to sep...

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Abstract

The invention provides hydrogel and application of an ampholytic hydrogel shaped body prepared from the hydrogel in medicine for detecting glucose content in urine. The ampholytic hydrogel shaped body comprises a monomer with telescopic performance and a monometer having response with glucose, a surface active agent and magnetic-induction particles are wrapped in copolymer of the two monomers, a moving route of the ampholytic hydrogel shaped body can be controlled by a magnetic field, and the moving distance and the glucose concentration of ampholytic hydrogel in the same period are calculated and analyzed to obtain a curve chart. The ampholytic hydrogel shaped body has the advantages of being low in detection limit in urine glucose detection and capable of visually and accurately detecting the glucose concentration in the urine.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a hydrogel for detecting glucose concentration. Background technique [0002] Glucose is the main energy source for human activities, and glucose detection is of great significance in biomedicine. In clinical medicine, diabetes seriously endangers human health, and its diagnosis and treatment have always been a major problem in the medical field. Urinary sugar (sugar in urine, mainly refers to glucose in urine) detection is the easiest way to diagnose diabetes early. When normal blood flows through the kidney, the glucose in it passes through the filtration of the glomerulus and the renal tubules The reabsorption of glucose makes the urine contain only a small amount of glucose, which cannot be detected by ordinary methods. However, the filtration and reabsorption of glucose by the kidney is limited. When the value exceeds a certain value, the function of the kidney cannot absorb all the glucose, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F220/54C08F220/58B01J13/00G01N33/50
CPCB01J13/0065C08F220/54C08J3/075C08J2333/24G01N33/50C08F220/585
Inventor 李明通李洁爱张慧董彬
Owner SUZHOU UNIV
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