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An on-line detector capable of continuous sample injection and application thereof

A detector and sampling device technology, which is applied in the field of continuous sampling on-line detectors, can solve the problems of time-consuming, etc., and achieve the effects of saving analysis time, fast detection speed, and less consumables

Inactive Publication Date: 2017-05-10
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

However, as a complex biological sample, blood must be pretreated before chromatographic separation, which makes the above methods time-consuming and mostly offline analysis, which cannot fully meet the needs of clinical anesthesia monitoring.

Method used

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  • An on-line detector capable of continuous sample injection and application thereof

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Embodiment Construction

[0022] The continuous sampling on-line detector adopts the traditional uniform field mobility spectrometry, and its structure diagram is shown in figure 1 . This instrument mainly includes the following parts: 1 is the sampling device, 2 is the ion transfer tube, 3 is the blood sample catheter, 4 is the thermal analysis chamber, 5 is the heat source device, 6 is the rotating motor, 7 is the roll sampling cloth, 8 is the carrier gas inlet, 9 is the sample inlet, 10 is the carrier gas outlet or the sample gas enters the transfer tube inlet, 11 is the ionization area of ​​the transfer tube, 12 is the ion gate, 13 is the migration area of ​​the transfer tube, 14 is the grid, 15 is Amplifier, 16 is an A / D converter, 17 is a data acquisition and processing system, 18 is a drift gas inlet, 19 is a gas outlet, and 20 is an ion receiving electrode.

[0023] The blood sample conduit 3 is connected with a flow controller to control the amount of sample injection, and the heat source dev...

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Abstract

An on-line detector capable of continuous sample injection is designed in the invention. According to the detector, an ion-mobility spectrometry technique as a base detection technique is adopted and sample thermal desorption analysis and headspace sample feeding techniques are combined. A sample with a complex matrix does not need pretreatment and is collected to the surface of a sampling sheet, the sampling sheet allows volatile components of the sample to be gasified in a thermal desorption analysis sample injector through a belt type conveying manner, and then the sample vapor is carried by a carrier gas to enter the detector and subjected to on-line detection and analysis. The detector achieves on-line continuous detection of propofol in human blood during operations and is used for directing clinical administration by doctors.

Description

technical field [0001] Based on the ion mobility spectrometry technology, the present invention designs an on-line detector for continuous sampling in combination with sample thermal analysis and headspace sampling technology. The detection device and method of the present invention are used to analyze the depth of clinical administration of propofol in blood, and to guide clinical anesthesiologists in precise medication. Background technique [0002] Thermal analysis technology is a two-in-one technology: it integrates sampling and concentration, and then transfers the sample from the sampling tube for detection. Dynamic headspace analysis, also known as purge-trap, is a method in which an inert gas is passed through a liquid sample (or a solid surface) to sweep out the components to be analyzed and pass through a container containing an adsorbent. After enrichment, the adsorbent is heated again to desorb the adsorbed components, and the carrier gas is used to carry it int...

Claims

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Application Information

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IPC IPC(8): G01N35/10G01N27/64G01N1/44
Inventor 李海洋王新李恩有张融李东明李京华
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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