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Diagnosis of cancer

A technology of cancer and oncoprotein, which is applied in the field of cancer diagnosis and disease diagnosis, and can solve the problems that hinder antibody therapeutics, the applicability of antibody therapeutics to cancer is not universal, and the large size of antibody molecules cannot pass through, etc.

Inactive Publication Date: 2017-05-24
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the applicability of antibody therapeutics to different cancers is not universal
One of the limitations hampering the common use of antibody therapeutics is the large size and subsequent inability of antibody molecules to cross plasma or cell membranes

Method used

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  • Diagnosis of cancer
  • Diagnosis of cancer
  • Diagnosis of cancer

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Embodiment Construction

[0050] We describe various immunological assays such as Western blot, dot blot, ELISA. We also describe a pregnancy-like test to detect cancer proteins in urine and blood samples (as well as saliva).

[0051] We investigated whether the levels of oncoproteins correlate with the stage of cancer.

[0052] Screening for biomarkers is easier with urine and blood samples than with tumor samples, which can be difficult to reach, such as brain tumors in an internal central location.

[0053] We have 2 independent monoclonal antibodies against PRL-3 (#318 or #223); we also have polyclonal rabbit antibodies reactive with PRL-3 and its relatives PRL-1 and PRL-2. In addition to Western blot and Elisa assays, we can prepare test strips containing PRL-3 clone antibody #318 or #223 for use in urine or serum (possibly saliva) samples The capture of PRL-3 antigen, which is a secondary antibody conjugated to HRP or AP, will clearly show the color of the antibody-antigenase reaction on the st...

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Abstract

The data provided herewith show that, biomarkers found within the cells of a tumor or cancer may also be present at adequate levels within the patient's urine to enable detection. Method of diagnosis, patient selection and treatment are provided, along with kits and devices.

Description

technical field [0001] The present invention relates to the fields of cell biology, molecular biology and biochemistry. The invention also relates to the medical field. In particular, the invention relates to the diagnosis of disease, especially cancer. Background technique [0002] Cancer has been the subject of extensive research over the past two decades. However, little is known about the underlying causes of cancer metastasis, and prevention of most types of cancer remains limited. [0003] Antibody-based therapies have proven effective for cancer treatment; however, this approach has traditionally been limited to extracellular or secreted proteins expressed by cancer cells. Thus, many potential cancer or tumor markers and cancer antigens have been identified in the literature, and antibody therapies against some of them have been developed. [0004] For example, the well-known cancer treatment Herceptin (trastuzumab) is a monoclonal antibody that kills HER2-positiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574A61K39/395
CPCG01N33/57488A61K2039/505G01N2333/916G01N33/5748C07K16/40C12Y301/03048A61P35/00G01N2333/82
Inventor 曾琦
Owner AGENCY FOR SCI TECH & RES