Skin cleaning liquid and preparation method thereof

A technology of skin cleaning and formulation, applied in the field of cleaning solution, can solve the problems of strong adhesion of anionic substances, affect the antibacterial effect, and not easy to rinse clean, so as to reduce equipment investment cost, inhibit bird flu virus, and transport and store safely and conveniently Effect

Inactive Publication Date: 2017-05-31
长江医学科学院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The antibacterial skin cleaning liquid sold on the market is mainly composed of anionic surfactants, skin care agents, pigments and essences and other substances. It has strong adhesion on the surface, is not easy to rinse off, and will have an antagonistic reaction with other cationic substances, while cationic substances have good water solubility and antibacterial properties, and their toxicity is relatively low
[0005] Due to the anionic properties in the skin cleansing liquid, the preparation of ordinary skin cleansing

Method used

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  • Skin cleaning liquid and preparation method thereof
  • Skin cleaning liquid and preparation method thereof
  • Skin cleaning liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A skin cleansing solution containing the following raw materials in percentage by weight:

[0034]

[0035]

[0036] A preparation method of skin cleansing solution, comprising the following steps:

[0037] 1. Add 0.01 kg of benzalkonium bromide to 0.1 kg of fatty alcohol polyoxyethylene ether, mix and stir for 2 hours at a normal temperature of 30°C and a normal pressure (1 atmosphere) with a mixer speed of 110 rpm, and then add to In the reactor;

[0038] 2. Add 0.05 kg of dodecyl dimethyl amine oxide to the reaction kettle;

[0039] 3. Then add 0.5 kg of polysorbate 80, 0.5 kg of sodium gluconate and 98.84 kg of pure water into the reaction kettle, and mix and stir at a normal temperature of 30°C and a normal pressure (1 atmospheric pressure) with a mixer speed of 510 rpm 6 hours to make the mixture dissolve evenly;

[0040] 4. After the above mixture is fully stirred, after standing and aging for 49 hours, test the content of active ingredients. The content...

Embodiment 2

[0042] A skin cleansing solution containing the following raw materials in percentage by weight:

[0043]

[0044] A preparation method of skin cleansing solution, comprising the following steps:

[0045] 1. Add 0.1 kg of benzalkonium bromide to 7 kg of fatty alcohol polyoxyethylene ether, mix and stir for 2 hours at room temperature 30°C, normal pressure (1 atmosphere) and mixer speed of 110 rpm, then add into the reactor;

[0046] 2. 8 kilograms of dodecyl dimethyl amine oxide are also added to the reaction kettle;

[0047] 3. Then add 3 kg of polysorbate 80, 5 kg of sodium gluconate and 76.9 kg of pure water into the reaction kettle, and mix under the conditions of normal temperature 30°C, normal pressure (1 atmosphere) and mixer speed of 510 rpm Stir for 6 hours to dissolve the mixture evenly;

[0048] 4. After the above mixture is fully stirred, after standing and aging for 49 hours, test the content of active ingredients. The content of active ingredients should be...

Embodiment 3

[0050] A skin cleansing solution containing the following raw materials in percentage by weight:

[0051]

[0052] A preparation method of skin cleansing solution, comprising the following steps:

[0053] 1. Add 3 kg of benzalkonium bromide to 15 kg of fatty alcohol polyoxyethylene ether, mix and stir for 2 hours at room temperature 30°C, normal pressure (1 atmosphere) and mixer speed of 110 rpm, then add to in the reactor.

[0054] 2. Add 10 kg of dodecyl dimethyl amine oxide into the reaction kettle.

[0055] 3. Then add 5 kg of polysorbate 80, 6 kg of sodium gluconate and 61 kg of purified water into the reaction kettle, and mix and stir under the conditions of normal temperature 30°C and normal pressure (1 atmospheric pressure) with a mixer speed of 510 rpm 6 hours to dissolve the mixture evenly.

[0056] 4. After the above mixture is fully stirred, after standing and aging for 49 hours, test the content of active ingredients. The content of active ingredients should b...

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PUM

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Abstract

The invention provides a skin cleaning liquid and a preparation method thereof. The skin cleaning liquid comprises the following raw materials in percentage by weight: 0.01-3% of benzalkonium bromide, 0.1-15% of fatty alcohol polyoxyethylene ether, 0.05-10% of lauryl dimethyl amine oxide, 0.5-6% of sodium gluconate, 0.5-5% of tween-80, and 61-98.84% of pure water. Compared with the prior art, the skin cleaning liquid provided by the invention overcomes the defect of poor compatibility of an anionic surfactant, and by virtue of a synergistic effect of a nonionic surfactant and a cationic surfactant, the skin cleaning liquid has the characteristics of uniformity, high efficiency and safety. The antibacterial rate of the product for intestinal tract pathogenic bacteria, pyogenic bacteria, pathogenic yeasts is 99% or higher; the skin cleaning liquid can effectively restrain avian influenza viruses, and hand, foot and mouth viruses; toxicological studies show that the acute oral toxicity LD50 value is 5000mg/kg or higher, and the skin cleaning liquid has no subacute toxicity, reaches an actual non-toxic level, and has no irritation to skin.

Description

technical field [0001] The invention belongs to the field of cleansing liquid, and specifically relates to a skin cleansing liquid and a preparation method thereof, which can be used as a professional skin cleansing liquid for medical personnel in the medical industry, and can also be used to develop corresponding civilian daily chemical products to be applied to people's daily households Life. Background technique [0002] With the rapid development of modern medical science and the improvement of awareness of nosocomial infection, the strict self-protection of medical staff can not only protect themselves, but also avoid the harm caused by nosocomial infection to patients. Nurses in the ICU of the hospital are mostly manual operations in nursing work. Hand hygiene is one of the most basic and effective measures to control nosocomial infection. Quick and effective hand washing method can not only reduce 50% nosocomial infection rate, but also improve work efficiency, prot...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/41A61K8/365A61Q19/10A61Q17/00
CPCA61K8/86A61K8/365A61K8/416A61K2800/5922A61Q17/005A61Q19/10
Inventor 吴晨露崔文玉沙正茂汪海
Owner 长江医学科学院
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