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Five-kernel soft capsule and preparation method thereof

A technology of soft capsules and capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, medical raw materials derived from gymnosperm subphylum, etc. Effects of adverse reactions

Inactive Publication Date: 2017-05-31
贵阳护理职业学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to reduce or avoid the harm of intestinal constipation and prevent and treat constipation, people have developed some health foods and medicines, such as Chinese Patent Application No. 2009101806669 "A Compound Wuren Composition with Moistening and Laxative Effects", No. 2013100506235 "A Kind of Drugs for Treating Constipation and Its Preparation Method", No. 2016102420923 "A Zhipu Wuren Laxative Suppository for Treating Constipation in Children and Its Preparation Method", etc. Although these technical solutions have some health care functions for preventing and treating constipation, the effect is unknown

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Wuren Soft Capsules

[0027] Take hemp seed 100g, Yu Liren 100g, Baiziren 50g, Trichosanthes kernel 100g and sweet almond 50g according to the formula, squeeze the five kernels respectively to obtain 65g of oil; the squeezed residue is steam distilled at 100°C for 120min to obtain volatile oil 15g, mixed for later use; the above oil was added into the auxiliary material polyethylene glycol 200 in a ratio of 1:1, mixed evenly, and machined to make soft capsules with glycerin gelatin as the capsule material; bottled, packaged, and passed the inspection to obtain Wuren soft capsules capsule.

Embodiment 2

[0028] Example 2 Preparation of Wuren Soft Capsules

[0029] Take hemp seed 100g, Yu Liren 100g, Baiziren 50g, Trichosanthes kernel 100g and sweet almond 50g according to the recipe, clean and press, put the oil separately, put the residue into a supercritical extraction kettle for extraction, the extraction pressure is 25MPa, extract The temperature is 50°C, the extraction time is 120min, CO 2 The flow rate is 18~20L · h -1 . The pressure of the separation tank I is controlled at 6 MPa and the temperature is 45°C; the pressure of the separation tank II is controlled at 5 MPa and the temperature is controlled at 35°C, and the oil can be obtained through separation, and the volatile oils of various raw materials are obtained, which are active ingredients and are used for later use; the above The oil is added with soybean oil and polyethylene glycol 300 as auxiliary materials in a ratio of 3:7, mixed evenly, and machined to make soft capsules with glycerin gelatin as the caps...

Embodiment 3

[0030] Example 3 Preparation of Wuren Soft Capsules

[0031] According to the formula, take 100g of hemp seed, 100g of Yu Liren, 50g of Baiziren, 100g of Trichosanthes kernel and 50g of sweet almond, clean them, dry them at 50°C for 10h, crush them to 0.42mm, and supercritical CO 2 Extraction, the extraction time is 5h, the extraction temperature is 45°C, and the extraction pressure is 30MPa, to obtain the volatile oils of various raw materials, which are the active ingredients, for use; add the above oils into the auxiliary materials polyethylene glycol 300 and Glycerin, mixed evenly, machine-made soft capsules with glycerin gelatin as the capsule material; pressed into aluminum-plastic foam boards, packaged, and passed the inspection to obtain Wuren soft capsules.

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PUM

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Abstract

The invention discloses a five-kernel soft capsule which comprises main materials and auxiliary materials, wherein the main materials consist of the following raw material extracts in parts by mass: 9-15 parts of fructus cannabis kernels, 10-15 parts of bunge cherry kernels, 5-10 parts of platycladi kernels, 10-15 parts of trichosanthes kirilowii kernels and 5-10 parts of sweet almond kernels; the auxiliary materials comprise one or more of soybean oil, polyethylene glycol, glycerinum and dimethicone; the polyethylene glycol is one or more of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400 and polyethylene glycol 600; the mass percentages of the main materials and the auxiliary materials are that the main materials account for 5-80% and the auxiliary materials account for 95-20%. A preparation method comprises the following steps: (1) extracting effective components; (2) adding the auxiliary materials, uniformly, and treating in a machine so as to obtain the soft capsule; (3) filling the capsule into a bottle, or pressing into an aluminum foil bubble-cap plate, packaging, and inspecting, thereby obtaining the qualified five-kernel soft capsule. The five-kernel soft capsule disclosed by the invention is rapid in absorption, good in taste, gentle in action, free of adverse reaction and applicable to patients suffering from intestinal dryness with constipation, and has the functions of moistening intestines and relaxing bowel and nourishing bodies and tonifying deficiency.

Description

technical field [0001] The invention relates to food, in particular to health food, in particular to Wuren soft capsule. Background technique [0002] As we all know, constipation may increase the risk of colon and rectal cancer. This is because long-term constipation will cause these toxic substances metabolized by the human body to not be excreted normally, but to be continuously reabsorbed, and these toxic substances will greatly stimulate the intestinal wall, which may cause inflammation and even canceration. Intestinal constipation causes toxic substances to be reabsorbed. When the detoxification capacity of the liver is exceeded, it will enter the brain of the human body with the blood, damage the central nervous system of the human body, and easily lead to senile dementia. Intestinal constipation can also cause gastrointestinal dysfunction, endocrine disorders, metabolic disorders, poor appetite and sleep, and mental stress; it can also lead to dull complexion, rough...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/48A61P1/10A23L33/105
CPCA61K36/60A23V2002/00A61K9/4825A61K9/4866A61K36/14A61K36/428A61K36/736A61K2236/331A61K2236/37
Inventor 夏忠玉孙国兵贾俊陈嬝嬝高晨曦
Owner 贵阳护理职业学院
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