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Use of lachnum intracellular melanin serving as acute liver injury medicine

A technology for acute liver injury and Trichoderma granulosa, which is applied in the application field of drugs for treating acute liver injury, and achieves the effects of reducing the level of inflammatory mediators, achieving good scale benefits and reducing the level of inflammatory factors.

Inactive Publication Date: 2017-07-07
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no literature publicly mentioning the application of Trichoma melanin as a protective agent against LPS / D-GalN-induced acute liver injury in mice

Method used

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  • Use of lachnum intracellular melanin serving as acute liver injury medicine
  • Use of lachnum intracellular melanin serving as acute liver injury medicine
  • Use of lachnum intracellular melanin serving as acute liver injury medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0009] (1) Preparation of intracellular melanin LIM30 from Trichomonas granulosa

[0010] The inventor's research group was preserved on March 2, 2011 in the Chinese Typical Culture Collection Center of the College of Life Sciences, Wuhan University, Wuchang, Wuhan City, and the bacterial strain preservation number was the bacterial strain of CCTCC No: M 2011054. The entity is inoculated in a fermenter, the medium formula is: glucose 20g / L, yeast extract 5.0g / L, peptone 5.0g / L, natural pH, the volume ratio of the loading coefficient is 0.7, the volume ratio of the inoculum is 5%, the culture temperature The temperature is 28°C, the ventilation rate is 1.0L / min, the stirring speed is 180r / min, and the fermentation time is 12 days; the fermentation broth is suction-filtered, the mycelium is collected, dried at 60°C, and the mass and concentration of the mycelium are 1mol The volume ratio of sodium hydroxide aqueous solution per L is 1:50, mix well, let stand at room temperature ...

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Abstract

The invention discloses a use of lachnum intracellular melanin serving as an acute liver injury medicine. The intracellular melanin LIM30 is prepared from lachnum with a culture preservation serial number of CCTCC No:M2011054, pharmacological experiments prove that the lachnum intracellular melanin LIM30 can greatly improve the liver indexes of mice subjected to acute liver injury, reduce the levels of ALT and AST, reduce the content of NF-K, reduce the inflammatory factors and inflammation related cytokines and has good anti-inflammatory and hepatoprotective effects; and in addition, LIM30 can increase anti-inflammatory cytokine levels in serum of the mice. The LIM30 is free of toxic or side effects, can be used for preparing anti-inflammatory and liver protective drugs, and can be prepared into all kinds of forms according to the conventional preparation methods of pharmaceutics, and is easy to take.

Description

technical field [0001] The invention belongs to the technical field of the application of intracellular melanin of Trichomona granulosa in pharmaceuticals, and specifically relates to the intracellular melanin (LIM30 for short) of Trichodia granulosum with the strain preservation number of CCTCC No: M 2011054 as a medicine for treating acute liver injury. application. Background technique [0002] Acute liver injury is a severe clinical syndrome that impairs liver function and leads to hepatocyte death within a short period of time. Acute liver injury caused by bacterial lipopolysaccharide (LPS) and D-galactosamine (D-GalN) is usually accompanied by a large number of inflammatory reactions. Clinically used therapeutic drugs such as dexamethasone are a class of glucocorticoids, which can quickly and effectively It has anti-inflammatory effects, but prolonged use can easily cause adverse reactions, such as hyperadrenocorticoid syndrome, and may further aggravate the condition...

Claims

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Application Information

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IPC IPC(8): A61K36/062A61P1/16A61P29/00
Inventor 叶明徐灿杨柳青李井雷杨柳
Owner HEFEI UNIV OF TECH
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