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Method using choline type deep-eutectic solvent to catalyze to synthesize aspirin

A technology of deep eutectic solvent and aspirin, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of poor catalyst recycling performance and environmental pollution, and achieve broad industrial production application prospects and environmental friendliness , the effect of simple synthesis method

Inactive Publication Date: 2017-07-07
NANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for the catalytic synthesis of aspirin using a choline deep eutectic solvent, so as to overcome the shortcomings of serious environmental pollution and poor performance of catalyst recovery and use in traditional aspirin production.

Method used

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  • Method using choline type deep-eutectic solvent to catalyze to synthesize aspirin

Examples

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Embodiment 1

[0029] Add 6.98g (50mmol) choline chloride and 4.50g (50mmol) oxalic acid into a 100mL round bottom flask, heat and stir at 80°C for 30min, until a colorless transparent choline chloride-oxalic acid eutectic mixture is formed, and cool to room temperature , vacuum-dried, yield 100%.

Embodiment 2

[0031] Add 6.98g (50mmol) choline chloride and 3.75g (25mmol) L-(+)-tartaric acid into a 100mL round bottom flask, heat and stir at 90°C for 40min until a colorless and transparent choline chloride-L-( +)-tartaric acid eutectic mixture, cooled to room temperature, vacuum-dried, yield 100%.

Embodiment 3

[0033] Add 6.98g (50mmol) choline chloride and 8.61g (50mmol) p-toluenesulfonic acid to a 100mL round-bottomed flask, heat and stir at 100°C for 40min until a colorless transparent choline chloride-p-toluenesulfonic acid low co- The mixture was melted, cooled to room temperature, and dried under vacuum with a yield of 100%.

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Abstract

The invention belongs to the technical field of green organic synthesis chemistry, and particularly relates to a method using a choline type deep-eutectic solvent to catalyze to synthesize aspirin. The method comprises the following steps of adding the choline type deep-eutectic solvent, salicylic acid and acetic anhydride into a reaction container; heating to react for 15 to 40min at the temperature of 70 to 80 DEG C; purifying a crude product after reaction, so as to obtain the aspirin. The method using the choline type deep-eutectic solvent to catalyze to the synthesize aspirin has the advantages that the operation is simple, the reaction condition is mild, the side effect is small, and the environment-friendly effect is realized; when the deep-eutectic solvent is prepared, the utilization rate of atoms is 100%; the purifying of the deep-eutectic solvent is not needed, the deep-eutectic solvent can be recycled, the green chemical development requirement is met, and the wide industrial production application prospect is realized.

Description

technical field [0001] The invention belongs to the technical field of green organic synthesis chemistry, and in particular relates to a method for catalytically synthesizing aspirin by using a choline deep eutectic solvent. Background technique [0002] Aspirin is one of the three classic drugs in the history of medicine in the world. Its chemical name is 2-(acetoxy)benzoic acid, also known as acetylsalicylic acid. It was first synthesized in 1853 and began to be used medicinally in 1899. It is water A representative drug of salicylic acid antipyretic and analgesic drugs. In recent years, studies have found that aspirin has a strong inhibitory effect on platelet aggregation, so it has been used in the prevention and treatment of cardiovascular and cerebrovascular diseases. At the same time, the latest research shows that aspirin can inhibit tumor growth and metastasis, and has anti-cancer and anti-cancer effects. In addition, aspirin also has new uses such as preventing s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/08C07C69/157
CPCC07C67/08C07C69/157
Inventor 王英磊李文欢刘学国杜朝军李津
Owner NANYANG INST OF TECH
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