Use of intermittent hypoxia system in thoracic aortic aneurysm treatment device

Abstract

The invention belongs to the field of medicine, and relates to application of an intermittent low-oxygen system in a thoracic aortic aneurysm treating device. The invention discloses the new application of the intermittent low-oxygen system which is used for treating the thoracic aortic aneurysm of mammals. It is proved that the intermittent low-oxygen system has an obvious treatment effect on the thoracic aortic aneurysm of the mammals, so that a new approach is provided for the clinic treatment of the thoracic aortic aneurysm. Besides, the invention further provides a device or equipment for treating the thoracic aortic aneurysm, and the device or equipment contains the intermittent low-oxygen system.

Description

technical field [0001] The invention belongs to the medical field and relates to the use of an intermittent hypoxia system in a thoracic aortic aneurysm treatment device. Background technique [0002] Thoracic aortic aneurysm (aneurysm of thoracic aorta) refers to the permanent and persistent expansion of the thoracic aortic sinus, ascending aorta, aortic arch or descending aorta due to various reasons, and presents tumor-like protrusion. Thoracic aortic aneurysms are almost asymptomatic during formation and development, and once ruptured, have a high fatality rate. In recent years, the incidence of thoracic aortic aneurysm is increasing year by year, and patients are mainly male (Howard DP, Banerjee A, Fairhead JF, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study. Circulation. 2013; 127(20):2031-2037.). At present, surgical resection is the main treatment for...

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Problems solved by technology

[0007] The present invention uses the animal three-gas incubator to simulate the state of chronic intermittent hypoxia (Chrominic IntermittentHypoxia, CIH). Through research, we have found that chronic intermittent hypoxia has an effect on β-aminopropionitrile (BAPN)-induced thoracic aortic aneurysm and dissection in mice. The formation of BAPN has good preventive and therapeutic effects, which can significantly reduce the incidence and mortality of BAPN-induced thoracic aortic aneurysm and dissection in mice, and significantly improve BAPN-induced elastic fiber disorder and thickening of the vessel wall. Its mechanism of action It may be related to the effect of intermittent hypoxia by promoting the expression of hypoxia-inducible factor HIF-1α, improving the activity and level of LOX gene, resisting the inhibition of BAPN on LOX, and increasing the tight connection between elastic fibers and collagen fibers in the vessel wall. Therefore, Intermittent hypoxia method can reduce or delay the occurrence and development of thoracic aortic aneurysm and related diseases caused by LOX gene defect

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