Application of THBS2 protein detection object in preparing hepatocellular carcinoma prognosis evaluation kit
A detection kit, a technology for hepatocellular carcinoma, applied in the biological field, can solve the problems of high recurrence and metastasis rate, poor 5-year survival rate, large individual differences, etc.
Active Publication Date: 2017-08-29
BEIJING PROTEOME RES CENT +1
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Problems solved by technology
At present, surgical operations such as liver resection are still the main treatment methods for hepatocellular carcinoma, but the postoperative recurrence and metastasis rates are high, and the 5-year survival rate is poor, with large individual differences
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Embodiment 1
[0039] Embodiment 1, enzyme-linked immunosorbent assay assay THBS2 protein abundance in serum
[0040] 1. Experimental materials
[0041] The serum samples were the preoperative serum of 46 patients with clinically confirmed hepatocellular carcinoma (HCC) with HBV chronic infection background, provided by Beijing Cancer Hospital.
[0042] 2. Experimental method
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The invention discloses an application of a THBS2 protein detection object in preparing a hepatocellular carcinoma prognosis evaluation kit. The invention provides an application of a substance for detecting content of THBS2 protein in hepatocellular carcinoma patient serum or plasma to be detected in preparing a product for predicting or assisting the prediction of prognosis survival time of the hepatocellular carcinoma patient. An experiment proves that the THBS2 protein can be used as a prognosis marker of the hepatocellular carcinoma. The high expression of the hepatocellular carcinoma patient serum THBS2 protein is significantly related to the poor prognosis, the survival prognosis of the hepatocellular carcinoma patient can be effectively evaluated by detecting the concentration of the THBS2 proteins in the serum of the hepatocellular carcinoma patient, so that the application of the THBS2 protein detection object has important significance on the post-operative monitoring and instructive treatment of the liver cancer patients.
Description
technical field [0001] The invention relates to the field of biotechnology, in particular to the application of a THBS2 protein detection substance in the preparation of a kit for evaluating the prognosis of hepatocellular carcinoma. Background technique [0002] Hepatocellular carcinoma (hepatocellular carcinoma, HCC) is one of the common malignant tumors with high morbidity and mortality. About 650,000 people die from HCC every year. At present, surgical operations such as liver resection are still the main treatment methods for HCC, but the postoperative recurrence and metastasis rates are high, and the 5-year survival rate is poor, with large individual differences. [0003] The prognosis of hepatocellular carcinoma refers to predicting the possible course and outcome of patients with hepatocellular carcinoma, such as the possibility of recovery, the possibility of recurrence after treatment, the possibility of patient survival after liver cancer diagnosis, and so on. T...
Claims
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Login to View More IPC IPC(8): G01N33/68G01N33/574
Inventor 贺福初孙薇张剑邢宝才孙龙钦刘伟
Owner BEIJING PROTEOME RES CENT
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