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Water-soluble supramolecular complexes

A supramolecular complex, water-soluble technology, applied in the direction of organic active ingredients, active ingredients of salicylic acid, active ingredients of hydroxyl compounds, etc., can solve the problems of difficult and expensive transportation and handling

Pending Publication Date: 2017-08-29
BRODA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel compositions disclosed in this document have a large moisture content, which makes transportation and handling difficult and expensive, and it is not known how to overcome this drawback

Method used

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Examples

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Embodiment Construction

[0185] The following non-limiting examples are provided to illustrate the properties of exemplary compositions of the invention. In the examples below, concentrations are expressed in weight percent (wt.%), and deionized water was used to prepare the formulations. Unless otherwise stated, formulations were prepared at room temperature of about 22°C.

[0186] Clear transparent hydrogels having the compositions of Table 1 were prepared by the following wet processing method.

[0187] Table 1 Hydrogel Containing 3% Salicylic Acid

[0188] Numbering

Element

Wt.%

Wt.(g)

1

Poloxamer 407

12.5

25.0

2

Deionized water

81.0

162.0

3

salicylic acid

3.0

6.0

4

Laureth-4

3.5

7.0

[0189] Poloxamer 407 was first dissolved in water while stirring at a temperature below 10°C. After a uniform homogeneous solution had formed, the temperature of the solution was raised to about 60°C. Add the salicylic acid...

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PUM

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Abstract

The invention discloses water-soluble supramolecular complexes. The water-soluble supramolecular complexes are formed from a water soluble block copolymer and at least one associative gelling adjuvant. The copolymer includes at least two blocks of polyethylene oxide and at least one block of polypropylene oxide. The adjuvant has a water solubility less than 0.5 g / 100ml at 20 DEG C. When combined with water, the complexes form a transparent reversely thermo-reversible hydrogel or solution that may be repeatedly hydrated and dehydrated. The hydrogel exhibits improved gelling efficiency and enhanced solubility and / or stability for sparely soluble and insoluble pharmaceutical agents. The complexes are useful in a variety of pharmaceutical and cosmetic products and applications and may be combined with an effective amount of a cosmetic, medicament, or diagnostic in a solid dosage form.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Nonprovisional Patent Application Serial No. 14 / 548,851, filed November 20, 2014, entitled "Water-Soluble Supramolecular Complexes," the contents of which are hereby adopted This application is incorporated by reference. technical field [0003] The present invention relates to water-soluble supramolecular complexes for the delivery of active ingredients in pharmaceutical preparations or cosmetics, in particular, water-soluble supramolecular complexes in solid form capable of forming transparent hydrogels or solutions when hydrated. Background technique [0004] Of course, the fields of application of active ingredients for humans and animals are wide-ranging, including, for example, the delivery and application of active ingredients for pharmaceutical and cosmetic use. A particularly desirable situation would be to provide compositions which are capable of dissolving and st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/21C08G65/329C08G65/332C08L71/02A61K8/86A61K8/368A61K8/34A61K8/41A61Q19/00A61Q19/02A61Q19/08A61K31/60A61K31/045A61K31/137A61K47/34A61K47/10A61P17/10A61P39/06A61P17/00
CPCA61K8/34A61K8/368A61K8/41A61K8/86A61K31/045A61K31/137A61K31/60A61K47/10A61K47/34A61Q19/00A61Q19/02A61Q19/08C08G65/329C08G65/332C08G65/3326C08J3/075C08J3/212C08L71/02A61K2800/10C08L2203/02C08G2650/58C08G2210/00C08J2371/02A61K2300/00A61K8/042A61K2800/48A61K8/90A61K2800/262A61P17/00A61P17/02A61P17/10A61P25/02A61P27/02A61P27/06A61P27/08A61P27/14A61P31/04A61P31/10A61P31/12A61P33/00A61P37/06A61P39/06A61P43/00A61K8/0216A61Q5/006
Inventor 吕绍祥J·吕L·刘
Owner BRODA TECH
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