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Biphenyl benzyl azoles emulsion agent and preparation method thereof

A technology of bifonazole and emulsion agent, applied in the field of medicine, can solve problems such as easy precipitation of drugs, unstable gel agent, etc., and achieves the effects of good coatability, convenient preparation method, and easy industrial production.

Inactive Publication Date: 2008-05-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water insolubility of bifonazole makes it more difficult to prepare the gel, and the prepared gel is unstable after absorbing water, and the drug is easy to separate out

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of bifonazole emulsion:

[0024] The composition of the prescription is: (according to 100 sticks, one stick is 15g, containing 150mg of medicine per stick)

[0025] Bifonazole

[0026] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight. Dissolve the prescription amount of bifonazole and vitamin E in oleic acid, add the prescription amount of Tween 80, glycerin, and benzoic acid to the water phase, emulsify in a water bath heated at 70°C, and add the water phase dropwise to the oil phase , and at the same time carry out magnetic stirring to obtain colostrum. The obtained colostrum was subjected to probe ultrasound with a power of 400w for 10 minutes to obtain end milk. Mix the final milk with the swollen Carbomer 940 and add an appropriate amount of triethanolamine to adjust the pH to about 7 to obtain the emulsion.

Embodiment 2

[0027] Embodiment 2: the preparation of bifonazole emulsion:

[0028] The composition of the prescription is: (according to 100 sticks, one stick is 15g, containing 150mg of medicine per stick)

[0029] Bifonazole

[0030] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight. Dissolve the prescription amount of bifonazole and butylated hydroxyanisole in oleic acid, add the prescription amount of Tween 20, glycerin, and benzoic acid into the water phase, emulsify in a water bath heated at 70°C, and add the water phase dropwise In the oil phase, magnetic stirring is carried out at the same time to obtain colostrum. The obtained colostrum was subjected to probe ultrasound with a power of 400w for 10 minutes to obtain end milk. Mix the final milk with the swollen Carbomer 940 and add an appropriate amount of triethanolamine to adjust the pH to about 7 to obtain the emulsion.

Embodiment 3

[0031] Embodiment 3: the preparation of bifonazole emulsion:

[0032] The composition of the prescription is: (according to 100 sticks, one stick is 15g, containing 150mg of medicine per stick)

[0033] Bifonazole

Oleic acid

Cremophor

E1-35

Butylated hydroxyanisole

Glycerin

Benzoic acid

Carbomer 940

Triethanolamine

15g

75g

37.5g

0.15g

4 5g

4.5g

15g

Appropriate amount

water

Add to 1500g

[0034] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight. Dissolve the prescription amount of bifonazole and butylated hydroxyanisole in oleic acid, add the prescription amount of Cremophor E1-35, glycerin, and benzoic acid to the water phase, and emulsify it in a water bath heated at 70°C, and drop the water phase Add it into the oil phase, and at the same time carry out magnetic stirring to obtain col...

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PUM

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Abstract

The invention pertains to the field of medical technology, which relates to a bifonazole emulgel and the preparation method. The prescription composition of the emulgel is that: 0.5 percent to 2 percent bifonazole, 5 percent to 15 percent oil phase, 65 percent to 90 percent water phase, 2 percent to 10 percent emulsifier and 0.5 percent to 10 percent gel matrix, the preparation method of the bifonazole emulgel is that: the bifonazole is firstly prepared into the emulsion and then is dispersed in the gel matrix, the obtained preparation for external use is the milky white colloidal semi-solid, which is even, fine, appropriate in thickness, rich in luster and better in coating. The preparation method of the invention is more convenient, economical and more easy for industrial production, and the prepared bifonazole emulgel has good stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a bifonazole external emulsion for treating superficial fungal infection and a preparation method thereof. Background technique [0002] Bifonazole (bifonazole) is also known as white skin azole, bifonazole. It was first synthesized by the Federal German Bell Research Center and registered in 1982. Domestically, it was synthesized by the Chinese Academy of Military Medical Sciences in 1988. It is a new nitrogen-substituted halogen-free imidazole topical antifungal drug. It is clinically used to treat skin fungal diseases such as skin ringworm. It has definite curative effect and long-lasting effect. It only needs to be applied once a day; it is safe and reliable, has good skin permeability, is not easy to be absorbed by the body, and has a long half-life in the stratum corneum; less percutaneous absorption , does not produce systemic side effects; widely used, does not produce ...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/00A61K47/24A61K47/32A61K47/34A61K47/44A61P31/10A61K47/06A61K47/26
Inventor 何仲贵荣蓉王永军
Owner SHENYANG PHARMA UNIVERSITY
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