Biphenyl benzyl azoles emulsion agent and preparation method thereof
A technology of bifonazole and emulsion agent, applied in the field of medicine, can solve problems such as easy precipitation of drugs, unstable gel agent, etc., and achieves the effects of good coatability, convenient preparation method, and easy industrial production.
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[0023] Example 1: Preparation of bifonazole emulsion:
[0024] The prescription composition is: (calculated based on 100 bottles, 1 bottle 15g, containing 150mg / bottle)
[0025] Bifonazole
[0026] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight for later use. Weigh the prescription amount of bifonazole and vitamin E to dissolve in oleic acid, add prescription amount of Tween 80, glycerin, benzoic acid to the water phase, emulsify under the condition of heating at 70℃ in a water bath, and add the water phase dropwise to the oil phase , And magnetic stirring at the same time to obtain colostrum. The obtained colostrum was subjected to probe ultrasound with a power of 400w and ultrasound for 10 minutes to obtain the final milk. Mix the final milk with the swollen Carbomer 940, add an appropriate amount of triethanolamine, and adjust the PH value to about 7 to obtain an emulsion.
Example Embodiment
[0027] Example 2: Preparation of bifonazole emulsion:
[0028] The prescription composition is: (calculated based on 100 bottles, 1 bottle 15g, containing 150mg / bottle)
[0029] Bifonazole
[0030] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight for later use. Weigh the prescription amount of bifonazole and butylated hydroxyanisole dissolved in oleic acid, add the prescription amount of Tween 20, glycerin, and benzoic acid to the water phase, emulsify under the condition of heating in a water bath at 70℃, and add the water phase dropwise In the oil phase, magnetic stirring is carried out at the same time to obtain colostrum. The obtained colostrum was subjected to probe ultrasound with a power of 400w and ultrasound for 10 minutes to obtain the final milk. Mix the final milk with the swollen Carbomer 940, add an appropriate amount of triethanolamine, and adjust the PH value to about 7 to obtain an emulsi...
Example Embodiment
[0031] Example 3: Preparation of bifonazole emulsion:
[0032] The prescription composition is: (calculated based on 100 bottles, 1 bottle 15g, containing 150mg / bottle)
[0033] Bifonazole
[0034] Preparation process: Add the prescribed amount of Carbomer 940 to an appropriate amount of water to swell overnight for later use. Weigh the prescription amount of bifonazole and butylated hydroxyanisole dissolved in oleic acid, add the prescription amount of Cremophor E1-35, glycerin, and benzoic acid to the water phase, emulsify in a water bath heated at 70℃, and drop the water phase. Add it to the oil phase and perform magnetic stirring at the same time to obtain colostrum. The obtained colostrum was subjected to probe ultrasound with a power of 400w and ultrasound for 10 minutes to obtain the final milk. Mix the final milk with the swollen Carbomer 940, add an appropriate amount of triethanolamine, and adjust the PH value to about 7 to obtain an emulsion.
[0035] The foll...
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