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Preparation method of radix bupleuri and Radix Scutellariae granules

A granule and Chaihuang technology, applied in the field of preparation of Chaihuang granules, can solve the problems of easy destruction of baicalin extraction, loss of Chaihu volatile oil, etc., and achieve the effects of improving extraction rate, enhancing curative effect and increasing content.

Active Publication Date: 2017-09-05
HENAN LINGYOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the purpose of the present invention is to address the deficiencies in the prior art, to provide a preparation method with high extraction rate of raw materials, little damage to the active ingredients of Bupleurum volatile oil and baicalin, and simple process, which solves the problem of Bupleurum bupleuri in the existing production process. The loss of volatile oil is serious, and the problem that baicalin is easily damaged during the extraction process achieves the effect of ensuring the efficacy of the medicine and improving the taste

Method used

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  • Preparation method of radix bupleuri and Radix Scutellariae granules
  • Preparation method of radix bupleuri and Radix Scutellariae granules
  • Preparation method of radix bupleuri and Radix Scutellariae granules

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Embodiment 1

[0024] A preparation method of chaihuang granules, comprising the steps of:

[0025] 1) Extraction of active ingredients of Bupleuri and embedding in volatile oil: take 2500g of Bupleurum decoction pieces, wash them, add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 Flow rate 1m1 / g crude drug min, extraction time 30min, get Bupleurum volatile oil and extraction residue, add water to decoct the residue once, add 10 times the amount of water to decoct for 3 hours, filter, and concentrate the filtrate into a clear paste with a relative density of 1.10 , add ethanol to the clear paste under stirring until the alcohol content is 60%, let it stand for more than 12 hours, filter and concentrate to obtain Bupleurum extract; embed the volatile oil with β-cyclodextrin to form a capsule The compound was ...

Embodiment 2

[0031] A preparation method of chaihuang granules, comprising the steps of:

[0032] 1) Extraction of active ingredients of Bupleuri and embedding in volatile oil: Take 2500g of Bupleurum decoction pieces, wash them, add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and CO 2The flow rate is 3m1 / g crude drug min, the extraction time is 50min, and the volatile oil and extraction residue of Bupleurum chinensis are obtained. The residue is decocted once with 10 times the amount of water and decocted for 3 hours, filtered, and the filtrate is concentrated into a clear paste with a relative density of 1.20 , add ethanol to the clear paste under stirring until the alcohol content is 60%, let it stand for more than 12 hours, filter and concentrate to obtain Bupleurum extract; embed the volatile oil with β-cyclodext...

Embodiment 3

[0038] A preparation method of chaihuang granules, comprising the steps of:

[0039] 1) Extraction of active ingredients of Bupleuri and embedding in volatile oil: take 2500g of Bupleurum decoction pieces, wash them, add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 22MPa, the temperature is 40°C, and CO 2 The flow rate is 2m1 / g crude drug min, the extraction time is 40min, and the volatile oil and extraction residue of Bupleurum bupleuri are obtained. The residue is decocted once with water, and decocted with 10 times the amount of water for 3 hours, filtered, and the filtrate is concentrated into a clear paste with a relative density of 1.15 , add ethanol to the clear paste under stirring until the alcohol content is 60%, let it stand for more than 12 hours, filter and concentrate to obtain Bupleurum extract; embed the volatile oil with...

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Abstract

The invention discloses a preparation method of radix bupleuri and Radix Scutellariae granules. The method comprises the following steps: 1, extraction of effective components of radix bupleuri, and volatile oil embedding; 2, extraction of effective components of Radix Scutellariae; 3, treatment of the effective components of Radix Scutellariae; 4, mixing and granulation; and 5, granule packaging. The preparation method of the radix bupleuri and Radix Scutellariae granules is systemically researched and comprehensively improved from the extraction and purification of the effective components to the mixing of the effective components of medicines and to the granulation of a preparation. The method has the advantages of high operability, quality guaranteeing, improvement of the content of radix bupleuri volatile oil in the radix bupleuri and Radix Scutellariae granules, and enhancement of the curative effect of the radix bupleuri and Radix Scutellariae granules to a certain degree.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine granules, and in particular relates to a preparation method of chaihuang granules. Background technique [0002] Chaihuang granule comes from the tenth volume of traditional Chinese medicine preparations issued by the Ministry. The State Food and Drug Administration issued a revised standard in 2008, the standard number: WS3-B-2009-95-2008. [Prescription] Bupleurum 1250g, Scutellaria baicalensis extract 90g; [Preparation method] For the above two flavors, add Bupleurum to decoct twice for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.10-1.20 To clean the ointment, add ethanol under stirring until the alcohol content is 60%, let it stand for more than 12 hours, filter, recover the ethanol from the filtrate, and concentrate to an appropriate amount; take the extract of Scutellaria baicalensis, mix it with the above-men...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/16A61K47/69A61P11/00A61P29/00
CPCA61K9/1652A61K36/233A61K36/539A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈兴元宋建峰
Owner HENAN LINGYOU PHARMA
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