Aescin gel and preparation method thereof

A technique for aescin and aescin, which is applied in the field of aescin gel and its preparation, can solve the problems of complex composition of aescin sodium, poor stability of external dosage forms, low oil-water distribution coefficient, etc., and achieves strong activity and stability. Good sex, short onset time

Inactive Publication Date: 2017-09-15
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing external preparations such as sodium aescinate ointment, aerosol, liniment come out at present, but, existing sodium aescinate external preparation has following shortcoming: 1. sodium aescinate salt solubility is very good, and oil-water partition coefficient is very low Low, poor transdermal absorption effect; 2. Sodium aescinate has complex components and unstable properties, and the stability of the external dosage form made is relatively poor; 3. Sodium aescinate external preparations are more irritating to the skin

Method used

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  • Aescin gel and preparation method thereof
  • Aescin gel and preparation method thereof
  • Aescin gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Preparation method: Take carbomer 0.8g, sodium alginate 0.3g, add 30% (weight concentration) ethanol solution 86.2g, stir and swell fully, then take aescin A 0.6g, aescin B 0.4g, isopropyl Alcohol 10g, Tween 80 0.2g, Azone 1g, Propylene Glycol 0.5g, after ultrasonic dissolution, add to the above swollen carbomer, stir evenly, add dilute hydrochloric acid dropwise to adjust pH to 6.2, stir evenly, to obtain.

Embodiment 2

[0025]

[0026]

[0027] Preparation method: take carbomer 0.5g, sodium alginate 0.5g, add 20% (weight concentration) ethanol solution 89.6g, stir and swell fully, then take aescin A 0.5g, aescin B 0.8g, isopropyl Alcohol 5g, Tween 80 0.1g, Azone 2g, Propylene Glycol 1g, after ultrasonic dissolution, add to the above swollen carbomer, stir evenly, add dilute hydrochloric acid dropwise to adjust pH to 6, stir evenly, to obtain.

Embodiment 3

[0029]

[0030] Preparation method: take 1g of carbomer, 0.2g of sodium alginate, add 80.3g of 40% ethanol solution, stir and swell fully, then take 1.2g of aescin A, 0.2g of aescin B, 15g of isopropanol, Tween 80 0.4g, azone 1.5g, propylene glycol 0.2g, after ultrasonic dissolution, add to the swollen carbomer, stir evenly, add dilute hydrochloric acid dropwise to adjust pH to 5.5, stir evenly, to get ready.

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Abstract

The invention discloses aescin gel. Active components of the aescin gel are aescin A and aescin B, the aescin A accounts for 0.3-1.5% of the total weight of the gel, the aescin B accounts for 0.1-0.8% of the total weight of the gel, and the rest gel substrates. The aescin gel is sufficient and rapid in transdermal absorption and short in effect time, and the aescin gel is more controllable in quality, good in stability and low in skin irritation as compared with an external sodium aescinate preparation.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to an aescin gel and a preparation method thereof. Background technique [0002] Aescin, also known as aescinic acid, is a general term for total saponins, β-aescin or isoaescin, etc. extracted from the seeds of Aesculus in the family Aescinaceae, belonging to triterpenoid saponins. The water solubility of aescin is poor. In order to increase its solubility, it is often made into sodium salt. Studies have shown that the components with higher content in sodium aescin are aescin A, B, C, and D. Sodium aescinate can reduce the increase of pathological capillary permeability, increase venous tension, reduce the exudation of inflammatory substances, have anti-inflammation, detumescence, pain relief, improve blood circulation, and promote the recovery of acute blunt soft tissue injury. [0003] Oral bioavailability of sodium aescinate is not high, and injection is more irritating to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/704A61K47/36A61P29/00A61P19/04A61P7/00
CPCA61K9/06A61K9/0014A61K31/704A61K47/36A61K2300/00
Inventor 石召华江强叶利春覃勤吴灯李群刘享平
Owner WUHAN AIMIN PHARMA
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