Composition for hair growth, hair nourishment or hair growth promotion containing melatonin with improved stability

A technology of melatonin and composition, applied in the directions of drug combination, medical preparation containing active ingredients, application, etc., can solve the problems of decreased photostability, difficulty in productization, low solubility, etc.

Active Publication Date: 2020-03-10
HYUNDAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, melatonin can be an alternative technical solution that can minimize various side effects of conventional hair loss treatment agents, but there are many difficulties in commercializing it in the form of external preparations due to a significant decrease in photostability and relatively low solubility

Method used

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  • Composition for hair growth, hair nourishment or hair growth promotion containing melatonin with improved stability
  • Composition for hair growth, hair nourishment or hair growth promotion containing melatonin with improved stability
  • Composition for hair growth, hair nourishment or hair growth promotion containing melatonin with improved stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0064] The preparation of embodiment preparation

[0065] Nine formulations containing four complex components of melatonin, D-panthenol, biotin, and nicotinamide were prepared for use in the present invention, and the specific components of the formulations are shown in Table 1 below.

[0066] The composition of embodiment preparation

[0067] Table 1

[0068]

[0069]

[0070]

[0071] Preparation methods of various formulations

[0072] Table 2

[0073]

[0074]

[0075] Embodiments 1 to 5 are used to determine the prescription of the basic preparation suitable for the efficacy, effect and properties of the composition of the present invention, and are applicable to the composition for ensuring stability and increasing absorption rate in embodiments 6 and 7 , In Example 8 and Example 9, the composition for securing the stability of the preparation from the chemical and physical changes caused by ultraviolet rays was applied.

experiment example 1

[0076] Experimental Example 1: Determination of Antioxidant Effect (DPPH)

[0077] Free radicals are regarded as the causative substances for inducing aging (for example, hair loss, skin aging), and the degree of antioxidant effect is measured by measuring the free radical scavenging activity using a photostabilizer.

[0078] In order to prepare the samples of the DPPH test group, 0.1 weight percent of melatonin, 0.01 weight percent of biotin, 0.06 weight percent of nicotinamide and 0.1 weight percent of D-panthenol were stirred for 10 minutes until completely dissolved in ethanol. Then, a DPPH (1-diphenyl-2-picrylhydrazyl) solution was prepared from 80 μg / mL so that the concentration of each fraction of 1 mL of the above solution became 2 mg / mL Dissolved in ethanol. After that, the color change of DPPH was measured by using an ultraviolet spectrophotometer at an absorption wavelength of 517 nm to measure the absorbance, and the result of the measured activity was substitute...

experiment example 2

[0084] Experimental Example 2: Determination of Stabilizing Effect of Dosage Form Composition

[0085] In order to determine the preparations suitable for the efficacy, effect and properties of the composition of the present invention, a composition comprising melatonin, biotin, D-panthenol and nicotinamide as active ingredients was prepared, and passed the photostability test, the The effect of the composition of the above active ingredients on the stability of melatonin was measured. Q1b (Stability Testing: Photo stability Testing of NewDrug Substances and Products) using a photostability chamber in accordance with the guidelines of the International Conference on Harmonization (ICH, International Conference on Harmonization) ), the test was carried out under the condition that the visual identification system (VIS) was 40klux.

[0086] The dosage form composition test groups (Example 1-Example 5) were prepared according to the method in Table 2. In addition, 50 g of sampl...

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PUM

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Abstract

The present invention relates to a pharmaceutical composition for a hair health or hair growth promotion, containing melatonin, dexpanthenol, biotin and nicotinamide as active ingredients. The composition of the present invention maximizes hair growth or hair health effects by stabilizing a preparation while improving the light stability of melatonin, which is a pharmacologically active ingredient, and significantly inhibiting scalp inflammation. Therefore, the composition of the present invention can be useful as an effective hair growth or hair health promoter or as an agent for preventing or treating hair loss, the composition simultaneously increasing light stability, preservability, convenience of administration and therapeutic effects.

Description

technical field [0001] This patent application claims priority based on Korean Patent Application No. 10-2015-0015524 filed with the Korean Patent Office on January 30, 2015, and the disclosures of the above patent application are incorporated herein by reference. [0002] The present invention relates to a hair growth, hair nourishing or hair growth promoting composition whose stability, medication compliance and therapeutic effect are significantly improved. Background technique [0003] The human hair loss cycle is roughly divided into anagen (anagen), middle anagen (catagen) and telogen (telogen). The anagen period is the period when the hair grows rapidly due to the vigorous cell division along with the activation of the dermal papilla. The anagen period varies depending on the type of hair, but in the case of hair, the anagen period is about 3 to 6 years. The hair that grows in the anagen period accounts for 80-90% of all hairs. For people who are in the stage of hai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/67A61K8/49A61K8/42A61Q7/00A61K31/455A61P17/14A23L33/15A61K31/164A61K31/4045A61K31/4188
CPCA23L33/15A23V2002/00A61K8/42A61K8/4913A61K8/492A61K8/673A61K31/164A61K31/4045A61K31/4188A61K31/455A61Q7/00A61K2300/00A23V2200/318A61K31/415A61K31/465
Inventor 李丰奭李东日全锐智俞永根
Owner HYUNDAI PHARMA
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