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New anti-inflammatory abietane type diterpene glucoside tripterycosideA

A kind of technology of diterpene glycoside and rosinane, applied in the field of medicine

Active Publication Date: 2017-10-13
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are very few reports on the abietane-type diterpene glycosides in Tripterygium wilfordii, and the abietane-type diterpene glycosides with anti-inflammatory activity have not been reported

Method used

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  • New anti-inflammatory abietane type diterpene glucoside tripterycosideA
  • New anti-inflammatory abietane type diterpene glucoside tripterycosideA
  • New anti-inflammatory abietane type diterpene glucoside tripterycosideA

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Cut 119 kg of dried root of Tripterygium wilfordii into slices, add 400 liters of 95% ethanol, and heat and reflux at 70°C to extract 3 times (1.5×1.5×1 hour). The extracts were combined, concentrated under reduced pressure to recover the solvent to obtain 12Kg of extract. The extract was dissolved several times with ethyl acetate, the ethyl acetate solutions were combined, and concentrated under reduced pressure to recover the solvent to obtain 1.87Kg of the ethyl acetate fraction.

[0048] 1.87kg of the extract from the ethyl acetate part was subjected to neutral alumina column chromatography (200-300 mesh, 22.5Kg), petroleum ether-ethyl acetate (1:0, 4:1, 3:2, 2: 3, V / V ) and ethyl acetate-methanol (1:0, 3:1, 1:1, 0:1, V / V ) gradient elution, collect 50L of each fraction, and obtain 8 elution fractions (Fr.1~Fr.8) in sequence.

[0049] The Fr.7 fraction (i.e.: the above ethyl acetate-methanol 1:1 elution fraction) (15.6g) was separated by MCI GEL-CHP 20P chromat...

Embodiment 2

[0053] Tablet preparation of tripterycoside A: Mix 50 mg of the compound with 25 mg of starch and 25 mg of dextrin, moisten with an appropriate amount of 30% ethanol, granulate conventionally, add an appropriate amount of magnesium stearate, mix, and compress into tablets.

Embodiment 3

[0055] Capsule preparation of tripterycoside A: Mix 50 mg of the compound with 60 mg of starch, 10 mg of dextrin, and 10 mg of powdered sugar, moisten it with an appropriate amount of 30% ethanol, granulate it conventionally, and put it into a hard capsule.

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Abstract

The present invention relates to the technical field of medicine, and discloses the structure, the separation and the identification of a new abietane type diterpene glucoside compound (named tripterycosideA) separated from Tripteryginum Wilfordii Hook. F, and applications of the new abietane type diterpene glucoside compound in preparation of anti-inflammatory drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new anti-inflammatory abietane-type diterpene glycoside tripterycoside A isolated and identified from Tripterygium wilfordii. Background technique [0002] Tripterygium ( Tripteryginum Wilfordii Hook. F) is a plant of the genus Tripterygium wilfordii in the family Euonymus, also known as Dalbergia root and Rhizoma chinensis, and its medicinal part is the root. According to the "National Compilation of Chinese Herbal Medicine", Tripterygium wilfordii is bitter in taste, pungent in nature, cool in nature, and has great poison. It has expelling wind, detoxification and insecticidal effects. External use controls rheumatoid arthritis, itchy skin, kills maggots, larvae, kills snails, poisonous rats. Tripterygium wilfordii is mainly distributed in Fujian, Hunan and Jiangxi. It is commonly used clinically to treat refractory immune hyperfunction diseases such as rheumatoid arthr...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P29/00
CPCC07H1/08C07H17/04
Inventor 刘建群伍秋珊舒积成张锐
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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