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A kind of synthesis method of monodisperse spiny gold nanoparticles

A gold nanoparticle and nanoparticle technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem of not being able to precisely control the number, length and width of thorns, and achieve high yield High and reproducible results

Active Publication Date: 2018-12-04
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the past ten years, spiny gold nanoparticles have been successfully synthesized by many methods. However, there are almost no methods for the synthesis of spiny gold nanoparticles that can precisely control the number, length and length of spines. wide
So far, the synthesis of spiny gold nanoparticles with precise control over the number, length and width of spines is still a great challenge.

Method used

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  • A kind of synthesis method of monodisperse spiny gold nanoparticles

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Embodiment 1

[0019] Soak the glassware (50ml beaker and 10ml serum bottle) in aqua regia for 2 hours, rinse with saturated sodium nitrate solution and ultrapure water several times, and dry for later use.

[0020] (1) Use ultra-pure water to calibrate the first chloroauric acid solution with a molar concentration of 10 mmol / liter and the second chloroauric acid solution with a molar concentration of 15 mmol / liter by ultraviolet-visible spectroscopy. The required raw materials sodium borohydride, silver nitrate, glutathione and ascorbic acid are respectively configured into solutions with ultrapure water, wherein the molar concentration of the sodium borohydride solution is 10 mmol / liter, and the molar concentration of the first silver nitrate solution is 10 mmol / liter, the molar concentration of the second silver nitrate solution is 2 mmol / liter, the molar concentration of glutathione is 0.1 mole / liter, and the concentration of ascorbic acid solution is 0.1 mole / liter (there is only one kin...

Embodiment 2

[0031] The present embodiment is similar to Example 1, other fixed conditions are consistent with Example 1, and the preparation molar concentration is the second chloroauric acid solution of 20 mmol / liter, and the second chloroauric acid solution added in the overgrowth solution of adjustment step (3) The consumption of acid solution is 100 microliters, and the consumption of ascorbic acid solution is 120 microliters (the volume ratio of ascorbic acid solution and the second chloroauric acid solution is 1.2), makes cetyltrimethylammonium chloride solution and chloroauric acid The volume ratio of the solutions is 10, the volume ratio of the silver nitrate solution to the chloroauric acid solution is 0.3, and the volume ratio of the ascorbic acid solution to the chloroauric acid solution is 1.2. The total amount of overgrowth solution was 1.25 milliliters, and 4.71 milliliters of ultrapure water was added to adjust the concentration. The volume ratio of ultrapure water to overgr...

Embodiment 3

[0034] (1) Use ultrapure water to calibrate the first chloroauric acid solution with a molar concentration of 20 mmol / liter and the second chloroauric acid solution with a molar concentration of 25 mmol / liter with UV-visible spectroscopy. The required raw materials sodium borohydride, silver nitrate, glutathione and ascorbic acid are respectively configured into solutions with ultrapure water, wherein the molar concentration of the sodium borohydride solution is 10 mmol / liter, and the molar concentration of the first silver nitrate solution 5 mmol / L, the molar concentration of the second silver nitrate solution is 1.5 mmol / L, the molar concentration of glutathione is 0.05 mol / L, the concentration of the first ascorbic acid solution is 0.1 mol / L, and the second ascorbic acid The concentration is 0.2 mol / L.

[0035] Cetyltrimethylammonium bromide and cetyltrimethylammonium chloride were used as surfactants to stabilize gold nanoparticles, and cetyltrimethylammonium bromide with ...

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Abstract

A kind of synthetic method of monodisperse spiny gold nanoparticle, comprises the following steps: (1) prepare the first chloroauric acid solution, the second chloroauric acid solution, the first silver nitrate solution, the second silver nitrate solution, glutathione Peptide solution, sodium borohydride solution, the first ascorbic acid solution, the second ascorbic acid solution, cetyltrimethylammonium bromide solution and cetyltrimethylammonium chloride solution; (2) preparation of growth solution; ( 3) preparing an overgrowth solution; (4) preparing rod-shaped gold nanoparticles; (5) preparing a rod-shaped gold nanoparticle solution; (6) mixing and stirring the rod-shaped gold nanoparticle solution with the overgrowth solution and ultrapure water, and standing at a constant temperature, Monodisperse spiny gold nanoparticles were obtained. This method can obtain monodisperse spiny gold nanoparticles with high yield, adjustable size, number of surface spines, length and width, and the ligands used can be exchanged with other biocompatible ligands to further expand application of gold nanoparticles.

Description

technical field [0001] The invention relates to a method for precisely synthesizing monodisperse thorny gold nanoparticles with different sizes, thorn numbers, lengths and widths, and belongs to the technical field of gold nanoparticle synthesis. Background technique [0002] Due to its unique optical, electrical, catalytic properties and good biocompatibility, gold nanomaterials have important application value in many fields such as optics, electronics, biology, catalysis, and the construction of new materials with two-dimensional and three-dimensional structures. . Many unique properties exhibited by gold nanoparticles are closely related to their shape, size and composition. Therefore, the research work on the morphology, size and composition of gold nanoparticles has been widely concerned by everyone. Firstly, gold nanoparticles have high biocompatibility; secondly, the surface of gold nanoparticles is easy to be functionalized; finally, gold nanoparticles have tunabl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/0553B22F1/07B22F1/054
Inventor 夏海兵毕翠霞
Owner SHANDONG UNIV
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