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Synthetic method for monodisperse spinous gold nanoparticles

A gold nanoparticle, nanoparticle technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem of not being able to precisely control the number, length and width of thorns, and achieve high productivity High, reproducible results

Active Publication Date: 2017-10-17
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the past ten years, spiny gold nanoparticles have been successfully synthesized by many methods. However, there are almost no methods for the synthesis of spiny gold nanoparticles that can precisely control the number, length and length of spines. wide
So far, the synthesis of spiny gold nanoparticles with precise control over the number, length and width of spines is still a great challenge.

Method used

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  • Synthetic method for monodisperse spinous gold nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Soak the glassware (50ml beaker and 10ml serum bottle) in aqua regia for 2 hours, rinse with saturated sodium nitrate solution and ultrapure water several times, and dry for later use.

[0020] (1) Use ultra-pure water to calibrate the first chloroauric acid solution with a molar concentration of 10 mmol / liter and the second chloroauric acid solution with a molar concentration of 15 mmol / liter by ultraviolet-visible spectroscopy. The required raw materials sodium borohydride, silver nitrate, glutathione and ascorbic acid are respectively configured into solutions with ultrapure water, wherein the molar concentration of the sodium borohydride solution is 10 mmol / liter, and the molar concentration of the first silver nitrate solution is 10 mmol / liter, the molar concentration of the second silver nitrate solution is 2 mmol / liter, the molar concentration of glutathione is 0.1 mole / liter, and the concentration of ascorbic acid solution is 0.1 mole / liter (there is only one kin...

Embodiment 2

[0031] The present embodiment is similar to Example 1, other fixed conditions are consistent with Example 1, and the preparation molar concentration is the second chloroauric acid solution of 20 mmol / liter, and the second chloroauric acid solution added in the overgrowth solution of adjustment step (3) The consumption of acid solution is 100 microliters, and the consumption of ascorbic acid solution is 120 microliters (the volume ratio of ascorbic acid solution and the second chloroauric acid solution is 1.2), makes cetyltrimethylammonium chloride solution and chloroauric acid The volume ratio of the solutions is 10, the volume ratio of the silver nitrate solution to the chloroauric acid solution is 0.3, and the volume ratio of the ascorbic acid solution to the chloroauric acid solution is 1.2. The total amount of overgrowth solution was 1.25 milliliters, and 4.71 milliliters of ultrapure water was added to adjust the concentration. The volume ratio of ultrapure water to overgr...

Embodiment 3

[0034] (1) Use ultrapure water to calibrate the first chloroauric acid solution with a molar concentration of 20 mmol / liter and the second chloroauric acid solution with a molar concentration of 25 mmol / liter with UV-visible spectroscopy. The required raw materials sodium borohydride, silver nitrate, glutathione and ascorbic acid are respectively configured into solutions with ultrapure water, wherein the molar concentration of the sodium borohydride solution is 10 mmol / liter, and the molar concentration of the first silver nitrate solution 5 mmol / L, the molar concentration of the second silver nitrate solution is 1.5 mmol / L, the molar concentration of glutathione is 0.05 mol / L, the concentration of the first ascorbic acid solution is 0.1 mol / L, and the second ascorbic acid The concentration is 0.2 mol / L.

[0035] Cetyltrimethylammonium bromide and cetyltrimethylammonium chloride were used as surfactants to stabilize gold nanoparticles, and cetyltrimethylammonium bromide with ...

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Abstract

The invention discloses a synthetic method for monodisperse spinous gold nanoparticles. The synthetic method comprises the following steps that (1) a first chloroauric acid solution, a second chloroauric acid solution, a first silver nitrate solution, a second silver nitrate solution, a glutathione solution, a sodium borohydride solution, a first ascorbic acid solution, a second ascorbic acid solution, a hexadecyl trimethyl ammonium bromide solution and a hexadecyl trimethyl ammonium chloride solution are prepared; (2) a growth solution is prepared; (3) an excessive growth solution is prepared; (4) rod-shaped gold nanoparticles are prepared; (5) a rod-shaped gold nanoparticle solution is prepared; and (6) the rod-shaped gold nanoparticle solution, the excessive growth solution and ultra-pure water are mixed and stirred, standing is conducted at the constant temperature, and the monodisperse spinous gold nanoparticles are obtained. According to the method, the monodisperse spinous gold nanoparticles which are high in yield and adjustable in size, number of surface thorns, length and width can be obtained, used ligand can be subjected to ligand exchange with other biocompatibility ligand, and application of the gold nanoparticles is further expanded.

Description

technical field [0001] The invention relates to a method for precisely synthesizing monodisperse thorny gold nanoparticles with different sizes, thorn numbers, lengths and widths, and belongs to the technical field of gold nanoparticle synthesis. Background technique [0002] Due to its unique optical, electrical, catalytic properties and good biocompatibility, gold nanomaterials have important application value in many fields such as optics, electronics, biology, catalysis, and the construction of new materials with two-dimensional and three-dimensional structures. . Many unique properties exhibited by gold nanoparticles are closely related to their shape, size and composition. Therefore, the research work on the morphology, size and composition of gold nanoparticles has been widely concerned by everyone. Firstly, gold nanoparticles have high biocompatibility; secondly, the surface of gold nanoparticles is easy to be functionalized; finally, gold nanoparticles have tunabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/0553B22F1/07B22F1/054
Inventor 夏海兵毕翠霞
Owner SHANDONG UNIV
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