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Heteropolyacid nano-molecular medicine as well as preparation method and application thereof

A technology of nano-molecules and heteropolyacids, applied in the field of medicine, can solve the problems of not having the function of contrast imaging, not having the performance of integrated diagnosis and treatment, etc.

Inactive Publication Date: 2017-10-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the nano-hybrid material has high anti-tumor activity, it does not have the function of contrast imaging, and still does not have the performance of integrated diagnosis and treatment.

Method used

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  • Heteropolyacid nano-molecular medicine as well as preparation method and application thereof
  • Heteropolyacid nano-molecular medicine as well as preparation method and application thereof
  • Heteropolyacid nano-molecular medicine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Na 13 [Gd(SiW 11 o 39 ) 2 ]·18H 2 O is dissolved in a phosphate buffer solution of pH=7.4, and human or bovine serum albumin is added thereto, and the molar ratio of human or bovine serum albumin to heteropolyacid molecules is 1:1, and mixed to prepare heteropolyacid nanomolecules drug.

[0047] The Na prepared in this example 13 [Gd(SiW 11 o 39 ) 2 ]·18H 2 O nanomolecular drug solution was injected into tumor-implanted mice at an administration amount of 50 μmol / kg, and nuclear magnetic resonance imaging was performed, and tumor-bearing mice not administered the drug were used as controls.

[0048] figure 1 For injecting Na 13 [Gd(SiW 11 o 39 ) 2 ]·18H 2 The nuclear magnetic resonance images of mice with O nanomolecule drug solution can observe very clear tumor images. In the control group of mice not injected with the drug, no tumor images were observed.

[0049] At the same time, X-ray radiation therapy was performed on the mice administered the drug...

Embodiment 2

[0051] The heteropolyacid molecule Li 9 [EuW 10 o 36 ]·20H 2 O is dissolved in a phosphate buffer solution of pH=7.4, and human or bovine serum albumin is added thereto, and the molar ratio of human or bovine serum albumin to heteropolyacid molecules is 2:1, and mixed to prepare heteropolyacid nanomolecules drug.

[0052] The Li prepared in this example9 [EuW 10 o 36 ]·20H 2 O nanomolecular drug solution was injected into tumor-implanted mice at an administration amount of 200 μmol / kg, and CT imaging was performed, and tumor-bearing mice not administered the drug were used as controls.

[0053] image 3 For the injection of Li 9 [EuW 10 o 36 ]·20H 2 The CT image of the nanomolecular drug solution of O and the mice not administered the drug, it can be observed that the injection of Li 9 [EuW 10 o 36 ]·20H 2 Very clear tumor images in mice treated with nanomolecular drug solutions of O. In mice not injected with the drug, no tumor images were observed.

[0054] ...

Embodiment 3

[0056] Na 30 [BiP 5 W 30 o 185 ]·48H 2 O is dissolved in a phosphate buffer solution of pH=7.4, and human or bovine serum albumin is added thereto, and the molar ratio of human or bovine serum albumin to heteropolyacid molecules is 5:1, and mixed to prepare heteropolyacid nanomolecules drug.

[0057] The Na prepared in this example 30 [BiP 5 W 30 o 185 ]·48H 2 O nanomolecular drug solution was injected into mice implanted with tumors at an administration amount of 300 μmol / kg, and X-ray radiation therapy was performed on the mice.

[0058] Na injection 30 [BiP 5 W 30 o 185 ]·48H 2 After the tumor-bearing mice with the O nanomolecular drug solution were treated with X-ray radiation, it was also possible to see that the tumor decreased significantly with the increase of the X-ray irradiation time. After 4 days of treatment, the tumor decreased by 92%.

[0059] At the same time, nuclear magnetic imaging was performed on mice administered the drug, and clear tumor i...

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Abstract

The invention provides a heteropolyacid nano-molecular medicine as well as a preparation method and an application thereof. The medicine comprises heteropolyacid or heteropolyacid salt molecules and a coating material coating the surface of heteropolyacid or the heteropolyacid salt molecules, wherein the heteropolyacid or heteropolyacid salt molecules have the structure shown in (I), (II) or (III). The heteropolyacid nano-molecular medicine can selectively interact with tumor cells and can be used as a contrast agent in magnetic resonance imaging and CT diagnosis of tumors; besides, the medicine molecules have strong oxidation-reduction quality and light sensitivity and thus can be used as medicines assisting in thermal therapy, meanwhile, the molecules have strong X-ray absorption capacity and thus can perform functions as auxiliary radiotherapy medicines, so that diagnosis and treatment of tumors can be realized simultaneously, integration of diagnosis and treatment can be realized, targeted treatment of tumors is enhanced, and the tumor treatment effect is improved.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a heteropolyacid nanomolecular medicine, a preparation method and application thereof. Background technique [0002] With the continuous advancement of medical science and technology, new progress has been made in various methods of cancer diagnosis and treatment. It has developed from a single method to a variety of diagnostic methods such as CT, MRI, and ultrasound, as well as surgery, chemotherapy, and radiotherapy. , biological therapy and other treatment methods. Today's cancer experts at home and abroad recognize that various methods for diagnosing and treating cancer have their own characteristics and advantages, as well as limitations and shortcomings. If only a single method is used, the curative effect will be greatly affected, and even lead to overall treatment. Failure, the best treatment can only be obtained by giving full play to the advantages of various treatment methods, m...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/04A61K49/10A61K47/12A61P35/00
CPCA61K41/00A61K41/0052A61K47/12A61K49/04A61K49/10
Inventor 张光晋谷占军
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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