Extraction method of oat alkaloid as well as spraying agent and preparation method thereof

A technology of oat alkaloids and extraction methods, which is applied in the direction of aerosol delivery, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of inconvenience in the medication process and patients' easy to feel pain

Active Publication Date: 2017-12-01
GUANGZHOU ADDITIVE FREE COSMETIC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of ointment and medicated oil is mostly used at home, and it is necessary to use hands or cotton swabs for medication. The medication process is inconvenient, and patients are prone to pain during the medication process
Traditional treatment sprays need to add preservatives due to contact with the air, which inevitably introduces irritants.

Method used

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  • Extraction method of oat alkaloid as well as spraying agent and preparation method thereof
  • Extraction method of oat alkaloid as well as spraying agent and preparation method thereof
  • Extraction method of oat alkaloid as well as spraying agent and preparation method thereof

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preparation example Construction

[0029] A method for preparing a spray, comprising: mixing the second main ingredients, raising the temperature to a first temperature of 75-90°C and keeping it warm for 10-30 minutes, then cooling down to a second temperature of 55-70°C, adding the mixed auxiliary materials and homogenizing , when the temperature is lowered to a third temperature of 40-50°C, add the first main ingredient and mix. Please refer to figure 1 .

[0030] Specifically, the high-purity water and allantoin in the second main ingredient are sequentially added into a clean emulsification pot, stirred and heated to 75-90°C and kept for 10-30 minutes, so that the urea sac can be completely dissolved. The first temperature is 75-90°C, which can ensure that the urea capsule can be dissolved well without damaging its structure because the temperature is too high. Preferably, the first temperature is 80-85°C.

[0031] After keeping warm for 10-30 minutes, cool down to the second temperature of 55-70°C, add ...

Embodiment 1

[0043] A method for extracting oat alkaloids, comprising: using a mixture of 1,2-pentanediol and 1,2-hexanediol to extract oat bran to obtain a crude extract, the extraction temperature is 55°C, and the extraction time is 2h , the ratio of oat bran to the mixed solution is 1g:7mL, and the crude extract is purified and concentrated by macroporous resin AB-8. Wherein, the weight ratio of 1,2-pentanediol to 1,2-hexanediol is 1:1.

[0044] A spray, mainly made of raw materials, the raw materials include the first main material, the second main material and auxiliary materials, the first main material includes 10 parts by weight of avenous alkaloid obtained by the above extraction, 2 parts by weight of 1,2-pentanediol 4 parts by weight of 1,2-hexanediol and 3 parts by weight of dimethyl glycyrrhizinate. The second main ingredient includes 3 parts by weight of allantoin and 30 parts by weight of ultrapure water. The auxiliary materials include 0.2 parts by weight of sodium hyaluro...

Embodiment 2

[0047] A method for extracting oat alkaloids, comprising: using a mixture of 1,2-pentanediol and 1,2-hexanediol to extract oat bran to obtain a crude extract, the extraction temperature is 60°C, and the extraction time is 2.5 h, the ratio of oat bran to the mixed solution is 1g:5mL, and the crude extract is purified and concentrated by macroporous resin AB-8. Wherein, the weight ratio of 1,2-pentanediol to 1,2-hexanediol is 1:0.3.

[0048] A spray, mainly made of raw materials, the raw materials include the first main material, the second main material and auxiliary materials, the first main material includes 15 parts by weight of avenous alkaloid obtained by the above extraction, 3 parts by weight of 1,2-pentanediol 2 parts by weight of 1,2-hexanediol and 4 parts by weight of dimethyl glycyrrhizinate. The second main ingredient includes 2 parts by weight of allantoin and 25 parts by weight of ultrapure water. The auxiliary materials include 0.2 parts by weight of sodium hya...

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Abstract

The invention provides an extraction method of oat alkaloid as well as a spraying agent and a preparation method thereof, and relates to the field of dermatitis treatment. The extraction method of the oat alkaloid comprises the following steps: utilizing mixed liquid of 1,2-pentanediol and 1,2-hexanediol to extract oat bran so as to obtain a crude extract, wherein the extraction temperature is 50-70 DEG C, the extraction time is 1-3h, and the ratio of the oat bran to the mixed liquid is equal to 1g to (5-10ml); purifying and concentrating the crude extract by using macroporous resin. The method provided by the invention can be used for effectively extracting the oat alkaloid. The spraying agent is mainly prepared from the following raw materials: a first main raw material, a second main raw material and an auxiliary material, wherein the first main raw material is prepared from the oat alkaloid, 1,2-pentanediol, 1, 2-hexanediol and dipotassium glycyrrhizate; the second main raw material is prepared from allantoin and water; the auxiliary material is prepared from sodium hyaluronate, 1,2-hexanediol and water. The spray is prepared by taking the oat alkaloid as a main active component, has an effect of repairing irritant dermatitis and is natural and free from toxic and side effects.

Description

technical field [0001] The invention relates to the field of dermatitis treatment, and in particular to an extraction method of oat alkaloids, a spray and a preparation method thereof. Background technique [0002] Glucocorticoids are known as skin opiates. Long-term abuse of beauty cosmetics or ointments containing glucocorticoids will cause toxic and side effects of hormones, resulting in serious skin diseases, so-called hormone-dependent dermatitis. Skin lesions are characterized by facial skin thinning, atrophy, flushing, telangiectasia, acne, and rosacea-like changes. The main subjective symptoms are burning, itching, pain, dryness, scaling, and tension. The general course of this disease is long, the condition is recurrent and difficult to heal, which greatly reduces the quality of life of the patient, and the clinical treatment is more difficult. The current treatment method mainly allows the skin to adapt by continuously reducing the dosage of hormones. In addition,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/12A61P17/00A61K31/4166A61K31/704
CPCA61K9/0014A61K9/12A61K31/4166A61K31/704A61K36/899A61K47/36A61K2236/333A61K2236/55A61K2300/00
Inventor 杨志喜
Owner GUANGZHOU ADDITIVE FREE COSMETIC CO LTD
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