Method for quickly screening benzedrine drugs and morphine drugs in hair on spot

Abstract

The invention relates to a method for quickly screening benzedrine drugs and morphine drugs in hair on the spot. The method sequentially comprises the following steps of step 1, placing the hair to be detected, and grinding media together in a grinding tube of a crusher, and performing grinding and pulverizing treatment for the first time in the grinding tube of the crusher; step 2, after the grinding is performed for the first time, adding a solvent to the grinding tube, dissolving the hair in the grinding tube, and performing grinding and pulverizing treatment for the second time in the grinding tube of the crusher; and step 3, taking liquid in the grinding tube after the grinding and pulverizing treatment is performed for the second time, performing detection on a corresponding colloidal gold plate, and displaying a screening result. Through the adoption of the method disclosed by the invention, the simple, convenient, quick and on-the-spot operation of screening the drugs in the hair can be realized; the method is high in specificity, high in selectivity, and high in sensitivity, and can be applied to screening the hair of actual drug addicts, and can be applied to the field of forensic toxicological analysis, and the screening and solving of relevant cases.

Description

technical field [0001] The present invention relates to a method for quickly screening drugs in hair, designs a grinding extraction technology and colloidal gold plate detection technology, and applies it to the method for screening amphetamines and morphine drugs in hair, especially relates to a rapid on-site screening method Methods for detecting amphetamines and morphines in hair. Background technique [0002] On November 22, 2016, the National Narcotics Control Office revised the "Measures for the Identification of Drug Addiction", adding that the method for identifying drug addiction is based on the detection of drugs in hair. Drugs are well absorbed by smoking or injection, and can penetrate the blood-brain barrier in large quantities and produce effects quickly. After drugs enter the human body, they are metabolized under the action of blood lipase, and then further metabolized after entering the liver. A considerable amount of drugs and metabolites enter the hair, a...

AI Technical Summary

Problems solved by technology

[0008] Both acidolysis and solvent extraction methods need to stay overnight, which takes a long time and cannot meet the needs of rapid screening. Drugs and their metabolites are unstable, have low content, and are easy to decompose when exposed to heat or placed for a long time. Therefore, methanol ultrasound is currently used. Other hair treatment methods, freeze grinding technology is a pretreatment technology developed in recent years, but the hair is always at -196°C during the treatment process, and the hair crushing treatment increases the contact area with the solvent, effectively improving the release of drugs in the hair Efficiency, but the freezing and grinding technology usually takes 3 hours, and a large amount of liquid nitrogen is required for freezing, which is costly

The above four hair treatment methods only provide samples for liquid chromatography mass spectrometry detection, and cannot be used for on-site rapid screening

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