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Particles for treating acute gastritis with high slow releasing effects and preparation method thereof

A slow-release technology for acute gastritis, applied in the field of acute gastritis treatment granules and its preparation, can solve the problems of large absorption area of ​​the small intestine and discounted drug efficacy

Inactive Publication Date: 2018-01-05
合肥创新医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the drugs for acute gastritis in the prior art enter the inner body after being absorbed in the small intestine and enter the blood to be absorbed. However, the absorption area of ​​the small intestine is large, and ordinary particles enter the large intestine before entering the blood circulation. The effect is greatly reduced, and the treatment of acute gastritis cannot be efficiently carried out, so it is urgent to develop a kind of acute gastritis treatment granules with high sustained release to solve the problems in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of acute gastritis treatment granule with high sustained-release property proposed by the present invention, its raw materials include by weight: 40 parts of Magnolia officinalis, 20 parts of Atractylodes atractylodes, 3 parts of patchouli, 6 parts of tangerine peel, 12 parts of dandelion, and 3.5 parts of hay , 4.5 parts of white peony root, 3 parts of malt, 4.5 parts of sea octopus, 6 parts of baiji, 10 parts of honeysuckle, 3 parts of forsythia, 2 parts of knotweed, 3 parts of toosendan, 4 parts of corydalis, 3 parts of Magnolia officinalis, 12 parts of adhesive, 5 parts of calcium alginate gel, and 3 parts of slow-release additive.

[0019] The sustained-release aid is prepared according to the following process: add 4 parts of concentrated hydrochloric acid dropwise to 6 parts of trimethylamine aqueous solution with a mass fraction of 20% at 4 ° C, add 3.5 parts of absolute ethanol and mix well, and adjust the pH to 8.0 , heated up to 10°C, then added dropwi...

Embodiment 2

[0022] A kind of acute gastritis treatment granule with high sustained-release property proposed by the present invention, its raw materials include by weight: 30 parts of Magnolia officinalis, 25 parts of Atractylodes atractylodes, 1 part of patchouli, 8 parts of tangerine peel, 8 parts of dandelion, and 5 parts of hay , 3 parts of white peony root, 4 parts of malt, 3 parts of sea octopus, 8 parts of Baiji, 5 parts of honeysuckle, 4 parts of forsythia, 1 part of knotweed, 4 parts of Toosendan, 3 parts of corydalis, 4 parts of Magnolia officinalis, 8 parts of adhesive, 8 parts of calcium alginate gel, and 1 part of slow-release additive.

[0023] The slow-release aid is prepared according to the following process: add 5 parts of concentrated hydrochloric acid dropwise to 4 parts of trimethylamine aqueous solution with a mass fraction of 25% at 3 ° C, add 2 parts of absolute ethanol and mix well, and adjust the pH to 8.2 , heated up to 8°C, then added dropwise 4 parts of epichl...

Embodiment 3

[0026] A kind of acute gastritis treatment granule with high sustained-release property proposed by the present invention, its raw materials include by weight: 50 parts of Magnolia officinalis, 15 parts of Atractylodes atractylodes, 5 parts of patchouli, 4 parts of tangerine peel, 16 parts of dandelion, and 2 parts of hay , 6 parts of white peony, 2 parts of malt, 6 parts of sea octopus, 4 parts of Baiji, 15 parts of honeysuckle, 2 parts of forsythia, 3 parts of knotweed, 2 parts of Toosendan, 5 parts of Corydalis, 2 parts of Magnolia officinalis, 16 parts of adhesive, 2 parts of calcium alginate gel, 5 parts of slow-release aid.

[0027] The sustained-release aid is prepared according to the following process: add 3 parts of concentrated hydrochloric acid dropwise to 8 parts of trimethylamine aqueous solution with a mass fraction of 15% at 5°C by weight, add 5 parts of absolute ethanol and mix well, and adjust the pH to 7.8 , heated up to 12°C, then added dropwise 1 part of e...

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Abstract

The invention discloses particles for treating acute gastritis with high slow releasing effects. The raw materials comprise the following components: officinal magnolia barks, rhizoma atractylodis, patchouli, dried orange peels, dandelion, licorice roots, white peony roots, malt, cuttlefish bones, bletilla roots, honeysuckle flowers, forsythia fruits, giant knotweed rhizomes, toosendan fruits, corydalis tubers, officinal magnolia barks, a modified adhesive, calcium alginate gel, and a slow release auxiliary agent. The traditional Chinese medicines are extracted and condensed into powder, the slow release auxiliary agent is added for kneading and granulating, the traditional Chinese medicine particles can be used for releasing traditional Chinese medicine components with high efficiency andhigh quality, and drug effects and treatment effects are improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a highly sustained-release granule for treating acute gastritis and a preparation method thereof. Background technique [0002] Acute gastritis refers to an acute inflammatory reaction of the gastric mucosa caused by various reasons, and is divided into four types: acute simple gastritis, acute erosive gastritis, acute corrosive gastritis, and acute suppurative gastritis. Most of the drugs for acute gastritis in the prior art enter the inner body after being absorbed in the small intestine and enter the blood to be absorbed. However, the absorption area of ​​the small intestine is large, and ordinary particles enter the large intestine before entering the blood circulation. The effect is greatly reduced, and the treatment of acute gastritis cannot be efficiently performed. Therefore, it is urgent to develop a treatment granule for acute gastritis with high su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61K9/16A61K47/34A61K47/24A61K47/36A61K47/04A61K47/18A61K47/10A61K47/22A61K47/14A61P1/04A61K35/618
Inventor 曹明成黄美容解启慧马永兰董宠
Owner 合肥创新医药技术有限公司
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