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Application of artemisinin compounds in the preparation of drugs for the treatment of liposarcoma
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A technology for liposarcoma and compound, applied in the field of medicine, can solve the problems of less toxic and side effects, easy to cause complications, inconvenient life of patients, etc., and achieve the effect of high safety and obvious therapeutic effect
Active Publication Date: 2019-08-20
北京维恩派科技有限公司
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[0003] At present, the treatment of liposarcoma is mainly based on surgical treatment, radiotherapy and auxiliary drug treatment, but surgical treatment not only causes great trauma to the patient's body, but also causes inconvenience to the patient's life, easily causes complications, and the treatment cost is high
In recent years, international pharmaceutical companies have invested heavily in the development of anti-liposarcoma drugs, and some new drugs and new treatments have been applied to clinical treatment. In 2015, the FDA approved Lartruvo developed by Eli Lilly and Company. TM Combined with doxorubicin for the treatment of soft tissue sarcoma, in January 2016, the FDA approved Halaven (eribulin mesylate) developed by the Japanese pharmaceutical company Eisai for the treatment of advanced or metastatic liposarcoma. However, the high cost of treatment and the tolerance challenges brought about by cytotoxic chemotherapy drugs have brought great pressure on the patient's economy and body. Therefore, the development of a drug with relatively less toxic side effects, Anti-liposarcoma drugs with definite curative effect and relatively broad spectrum, which are affordable by ordinary people, have become an urgent need
So far, there have been no relevant reports on artemisinin compounds against liposarcoma
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Embodiment 1
[0025] Embodiment 1, the clinical practice of artemether treatment liposarcoma
[0026] 1 Materials and methods
[0027] 1.1 Clinical data
[0028] From June 2015 to February 2017, a total of 6 patients with liposarcoma were treated in Kunming Medicine Hospital. Among them, 2 patients received palliative treatment due to economic reasons after failure of other treatments, and the remaining 4 patients received the method of this study, that is, artemether The general clinical data are shown in Table 1. Inclusion criteria of this study: Sarcoma patients who failed or refused surgery, radiotherapy and chemotherapy, and the last treatment (surgery, chemotherapy, radiotherapy) was completed for at least 1 month. Age ≥18 years; histologically confirmed liposarcoma. Other inclusion criteria include: expected survival of at least >3 months; normal or nearly normal blood tests and liver and kidney functions. All patients voluntarily received artemether treatment and signed an infor...
Embodiment 2
[0066] Embodiment 2, the preparation of artemisinin compound tablet
[0067] The artemisinin compound is mixed with conventional auxiliary materials, and the artemisinin compound tablet is prepared according to a conventional method.
[0068] Wherein, the artemisinin compounds are as follows:
[0069]
[0070] Preferably, the artemisinin compound is artemether, as shown below:
[0071]
Embodiment 3
[0072] Embodiment 3, the preparation of artemisinin compound oral liquid
[0073] The artemisinin compound is mixed with conventional auxiliary materials, and the artemisinin compound oral liquid is prepared according to a conventional method.
[0074] Wherein, the artemisinin compounds are as follows:
[0075]
[0076] Preferably, the artemisinin compound is artemether, as shown below:
[0077]
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Abstract
The invention relates to the field of medicines, and in particular relates to applications of artemisinin compounds in preparing medicines for treating liposarcoma. The artemisinin compounds are shownin the description. The experiment proves that the compounds can obviously prolong the progression free survival (PFS) of patients and improve the life quality of the patients, while the number of circulating tumor cells (CTCs) is obviously reduced, the ratios of T cell subsets in the peripheral blood are obviously improved, in addition, the safety is high, and the applications are disclosed forthe first time and have the outstanding substantive features. The substances can be applied to preparation of medicines for treating liposarcoma and have good market application prospects.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the application of an artemisinin compound in the preparation of a drug for treating liposarcoma. Background technique [0002] Liposarcoma (liposarcomas) is a common malignant soft tissue tumor, which originates from mesenchymal cells differentiated from lipoblasts to adipocytes. According to different cell components, liposarcoma can be divided into: ① Well-differentiated liposarcoma, also known as fat Tumor-like liposarcoma; ②myxoid liposarcoma; ③round cell liposarcoma; ④pleomorphic liposarcoma; The disease is more common in patients aged 30 to 70, and the most common disease is around the age of 50. Men outnumber women. Extremities, especially thighs and buttocks are prone to occur. Upper limbs, retroperitoneum, head, and neck masses are more common with a diameter of 3 to 10 cm, and those with a large retroperitoneum can reach a diameter of more than 20 cm. The tumor is often nodul...
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