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Photodynamic therapy photosensitizer singlet oxygen quantum yield measurement method and device

A technology of photodynamic therapy and measurement method, which is applied in the direction of measuring device, color/spectral characteristic measurement, material analysis through optical means, etc., can solve problems such as the difficulty of singlet oxygen quantum yield, and achieve high measurement efficiency and automation level , sensitive reaction, good absorption spectrum effect

Inactive Publication Date: 2018-01-16
HARBIN INST OF TECH
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Problems solved by technology

However, it is very difficult to directly measure the singlet oxygen quantum yield of photosensitizers.

Method used

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  • Photodynamic therapy photosensitizer singlet oxygen quantum yield measurement method and device
  • Photodynamic therapy photosensitizer singlet oxygen quantum yield measurement method and device

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Embodiment Construction

[0036] Now in conjunction with embodiment the present invention is described in further detail. It should be understood that this embodiment is only used to illustrate the present invention, but not to limit the protection scope of the present invention.

[0037] A method for measuring the singlet oxygen quantum yield of a photosensitizer for photodynamic therapy, comprising the steps of:

[0038] (1) start the spectrometer 7, turn on the indicator light, the cuvette 9 is empty, the first movable baffle 3 blocks the laser light source 1 under the control of the first steering gear 10, and the second movable baffle 4 is in the second steering gear 11 Block the deuterium lamp 2 under the control, and measure the background spectrum with the spectrometer 7;

[0039] (2) Put the mixed solution of the photosensitizer to be tested and methanol (at this time, the photosensitizer to be tested is hematoporphyrin monomethyl ether (HMME), and the concentration of hematoporphyrin monomet...

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Abstract

The invention discloses a photodynamic therapy photosensitizer singlet oxygen quantum yield measurement method and device; the device mainly includes a laser light source, a deuterium lamp, a first mobile baffle plate, a second mobile baffle plate, a plane reflecting mirror, a convex lens, a spectrometer and a PC, wherein the first mobile baffle plate is arranged between the laser light source andthe plane reflecting mirror and can be used for shielding the laser light source; the second mobile baffle plate is arranged behind the deuterium lamp and can be used for shielding a light source ofthe deuterium lamp; the plane reflecting mirror is used for reflecting the laser light source to a colorimetric dish; the convex lens is used for converting diverging light emitted by the deuterium lamp into parallel light to irradiate to the colorimetric dish, the transmission light after the deuterium lamp irradiates the colorimetric dish is conducted to the spectrometer through an optical fiber, and the spectrometer transmits the measured data to the PC. The photodynamic therapy photosensitizer singlet oxygen quantum yield measurement method and device have the advantages of high signal-to-noise ratio, high measurement accuracy, high measurement efficiency, high automation level and the like.

Description

technical field [0001] The invention relates to a method and device for measuring the singlet oxygen quantum yield of a photosensitizer for photodynamic therapy and belongs to the technical field of photodynamic therapy. Background technique [0002] Photodynamic therapy (PDT) has been used for the treatment and diagnosis of superficial cancers for a long time. The principle of its treatment is: after the photosensitizer is injected into human organs, the photosensitizer is selectively absorbed and gathered near the tumor cells; the diseased tissue is irradiated with excitation light of a suitable wavelength, and the photosensitizer is excited under the action of the excitation light. Generate singlet oxygen; singlet oxygen selectively kills tumor cells, so as to achieve the therapeutic effect. [0003] The curative effect of photodynamic therapy is mainly related to the concentration of oxygen molecules, photosensitizer concentration, excitation light intensity and singlet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/01G01N21/39
Inventor 李中伟张治国秦峰臧立新张鹏伟张宝军张啸
Owner HARBIN INST OF TECH
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