A micro-block polymer for long-acting sustained-release preparations and its preparation method and use

A slow-release preparation and polymer technology, applied in the polymer field, can solve the problems of slow polymerization rate, poor solubility, fast polymerization rate, etc., and achieve the effects of moderate degradation speed, moderate block property, and reasonable design.
CN107698747BActive Publication Date: 2018-10-02SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
Publication Date
2018-10-02

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention discloses a micro-block polymer for long-acting sustained-release preparations and a preparation method thereof. The micro-block polymer includes a glycolide block and A with a weight ratio of 1-5:4-8 Component block; the A component is lactide, caprolactone, trimethylene carbonate or p-dioxanone; the molecular weight of the micro-block polymer is 5000~500000; glycolide block The average sequence length of glycolide in the segment is 3 to 5; the micro-block polymer used for long-acting sustained-release preparations of the present invention adjusts the microstructure of the entire polymer by adjusting the segment sequence length and distribution of glycolide The degradation rate and solubility of the long-acting sustained-release preparation can be adjusted accordingly; the LGG used in this application is between 3 and 5, the structure of the polymer is regular, the degradation rate is moderate, and there will be no sudden release of the drug , and the blockiness of the polymer is moderate, the solubility in most organic solvents is good, and it is suitable for the preparation process of most pharmaceutical preparations.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of macromolecules, in particular to a micro-block polymer for long-acting sustained-release preparations, a preparation method and application thereof. Background technique

[0002] Sustained-release preparation means that the drug is contained in the carrier matrix in the form of dissolution or dispersion. After acting on the human body, the drug can be released slowly and stably for a long time to achieve the effect of improving curative effect, reducing side effects and improving patient tolerance. The main dosage forms are microspheres, implants, gels, transdermal preparations, liposomes, micelles, etc. Among them, the long-acting sustained-release preparations have the characteristics of targetability, high drug stability, and long sustained-release period. In recent years, it has become a focus of intensive research by scholars from various countries.

[0003] Long-acting sustained-release preparation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More