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Flos lonicerae and radix scutellariae solution preparation for atomization inhalation and preparation method of silver yellow solution preparation

An atomization inhalation and solution technology, applied in the field of pharmacy, can solve problems such as hidden dangers of use and the lack of standardized use methods in the instructions, and achieve the effects of improving safety, reducing dosage and avoiding damage.

Inactive Publication Date: 2018-03-09
ZHEJIANG WECOME MEDICINE IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, nebulized inhalation with injection is often used, but there is no standardized method of use in the instructions, and there are potential safety hazards in use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Preparation of silver yellow extract:

[0035] Preparation of honeysuckle extract: Decoct honeysuckle with water twice, first time for 1 hour, and second time for 45 minutes to filter, the filtrate is combined and concentrated under reduced pressure to 2g of honeysuckle per ml, add 20% milk of lime, adjust When the pH value reaches 12-13, stir well, let it stand, filter, discard the filtrate, add 2 times the amount of ethanol to the precipitate, stir well, pass through a No. 4 sieve, adjust the pH value to 3-4 with 50% sulfuric acid solution, stir well, Filtrate, neutralize the filtrate with 40% sodium hydroxide solution to pH6.5-7.0, filter, concentrate the filtrate under reduced pressure to form a thick paste, dry it, and the product should contain no less than 18% chlorogenic acid;

[0036] Preparation of Scutellaria baicalensis extract: decoct Scutellaria baicalensis with water twice, 1 hour each time, filter, combine the filtrate, adjust the pH value to 1-2 wit...

Embodiment 2

[0045] (1) Preparation of Silver Yellow Extract: Same as Example 1.

[0046] (2) Preparation of Yinhuang solution for atomized inhalation:

[0047] Honeysuckle extract calculated as chlorogenic acid 8.75g

[0048] Scutellaria baicalensis extract calculated as pure baicalin 14g

[0049] Sodium chloride 5g

[0050] Add purified water to 1000ml

[0051]Weigh the two extracts according to the prescription amount, add water for injection and 8% sodium hydroxide solution to dissolve, mix, add water for injection to about 980ml, adjust the pH value to 7.2 with 8% sodium hydroxide solution, add an appropriate amount of activated carbon , heated on a water bath for 1 hour, let cool, filtered, added 5g of sodium chloride to the filtrate, added water for injection to 1000ml, adjusted the pH value to 7.3, ultrafiltered, potted and sterilized to obtain the solution preparation of the present invention .

[0052] The obtained nebulized inhalation solution preparation is nebulized by an...

Embodiment 3

[0054] (1) Preparation of Silver Yellow Extract: Same as Example 1.

[0055] (2) Preparation of Yinhuang solution for atomized inhalation:

[0056] Honeysuckle extract calculated as chlorogenic acid 6.25g

[0057] Scutellaria baicalensis extract calculated as pure baicalin 10g

[0058] Calcium chloride 4g

[0059] Add purified water to 1000ml

[0060] Weigh the two extracts according to the prescription amount, add water for injection and 8% sodium hydroxide solution to dissolve, mix, add water for injection to about 980ml, adjust the pH value to 7.2 with 8% sodium hydroxide solution, add an appropriate amount of activated carbon , put on a water bath and heat for 1 hour, let cool, filter, add 4g calcium chloride to the filtrate, add water for injection to 1000ml, adjust the pH value to 3.5, perform ultrafiltration, potting, and sterilize to obtain the solution preparation of the present invention .

[0061] The obtained nebulized inhalation solution preparation is nebuli...

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PUM

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Abstract

The invention relates to a flos lonicerae and radix scutellariae solution preparation for atomization inhalation, which belongs to the field of technology of pharmaceutics. The flos lonicerae and radix scutellariae solution preparation for the atomization inhalation is prepared from (1) flos lonicerae and radix scutellariae active ingredients; and (2) isotonic agent and solvent. The solution preparation prepared by the invention fills the gap of the domestic market at present; and moreover, the solution preparation prepared by the invention is designed particularly for an atomization inhalation patient; the prepared atomization inhalation solution preparation is atomized by virtue of an ultrasonic atomizer or an air compression-type atomizer and is directly inhaled into a respiratory system in a mist form, the use process is convenient, compared with the flos lonicerae and radix scutellariae injection, an administration route is different, the use dosage is reduced, the solution preparation can take effect quickly, the safety is improved, and an effect for treating upper respiratory inflammation and pharyngitis can be better played.

Description

technical field [0001] The invention relates to a silvery yellow solution preparation for atomized inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Yinhuang is a classic Chinese patent medicine. The main ingredients are honeysuckle extract and baicalin. It has the effects of clearing away heat, detoxifying and relieving sore throat. For upper respiratory tract infection, acute tonsillitis, pharyngitis. Existing Yinhuang preparations include granules, tablets, capsules, oral liquids, injections, dropping pills, buccal tablets, soft capsules, etc. Because of its clear curative effect, it is welcomed by both doctors and patients, and is a typical representative of traditional Chinese medicine for clearing away heat and detoxifying. [0003] Due to the traditional oral dosage form, the onset of action is slow and the dosage is large. The injection is relatively fast onset, but after the administration of the inject...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/08A61K9/72A61P11/00A61P11/04
CPCA61K9/0078A61K9/08A61K36/355A61K36/539A61K47/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张保献李艳英
Owner ZHEJIANG WECOME MEDICINE IND
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