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A kind of double fish particle quantitative fingerprint detection method

A technology of fingerprint spectrum and detection method, which is applied in the field of quantitative fingerprint spectrum detection of Shuangyu particles

Active Publication Date: 2021-02-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no clear report on the quality control method of Shuangyu Granules in the prior art. Therefore, in order to ensure its quality and curative effect, it is of great significance to provide a quality control method for Shuangyu Granules to better control its quality.

Method used

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  • A kind of double fish particle quantitative fingerprint detection method
  • A kind of double fish particle quantitative fingerprint detection method
  • A kind of double fish particle quantitative fingerprint detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, a method for detecting the quantitative fingerprint of Shuangyu particles, the method uses the following method to establish the quantitative fingerprint of Shuangyu particles: using high performance liquid chromatography,

[0047] Chromatographic conditions and system adaptability test: octadecylsilane bonded silica gel is used as filler, chromatographic column: Kromasil C18, column length is 250mm, inner diameter is 4.6mm, particle size is 3.5μm; acetonitrile is used as mobile phase A, Use 0.05% trifluoroacetic acid as mobile phase B, gradient elution, 0-50min, 5%A-70%A; flow rate is 0.8ml per minute; detection wavelength is 230nm and 327nm; column temperature is 30°C.

[0048] The gradient elution procedure is as follows:

[0049]

[0050]

[0051] After establishing the quantitative fingerprint of the Shuangyu granule, measure the quantitative fingerprint of the Shuangyu granule sample to be tested in the same way, and then compare it with the qu...

Embodiment 2

[0057] Example 2, a quantitative fingerprint detection method of Shuangyu particles, the method adopts the following method to establish quantitative fingerprints of Shuangyu particles: high performance liquid chromatography, chromatographic conditions and system adaptability test: chromatographic column C18, with acetonitrile as mobile phase A, with a volume concentration of 0.05% trifluoroacetic acid as the mobile phase B, gradient elution, 0-50min, 5%A-70%A; the flow rate is 0.7ml per minute; the detection wavelength is 230nm and 327nm; the column temperature is 25°C. All the other are identical with embodiment 1.

Embodiment 3

[0058] Example 3, a method for detecting quantitative fingerprints of Shuangyu granules, which uses the following method to establish quantitative fingerprints of Shuangyu granules: high performance liquid chromatography, chromatographic conditions and system adaptability test: chromatographic column C18, with acetonitrile as mobile phase A, with a volume concentration of 0.05% trifluoroacetic acid as the mobile phase B, gradient elution, 0-50min, 5%A-70%A; the flow rate is 0.9ml per minute; the detection wavelength is 230nm and 327nm; the column temperature is 35°C. All the other are identical with embodiment 1.

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Abstract

The invention is a quantitative fingerprint detection method of Shuangyu particles. The method adopts the following method to establish the quantitative fingerprint of Shuangyu particles: high performance liquid chromatography, chromatographic conditions and system adaptability test: chromatographic column C18, with acetonitrile as mobile phase A , with a volume concentration of 0.05% trifluoroacetic acid as mobile phase B, gradient elution, 0~50min, 5%A~70%A; flow rate is 0.7~0.9 ml per minute; detection wavelength is 230 nm and 327 nm; column temperature 25~35℃. The method of the invention can reflect the variation of the main component content of the double fish granule, and is used for better evaluating and controlling the quality of the double fish granule.

Description

technical field [0001] The invention relates to a quality control method for traditional Chinese medicine preparations, in particular to a quantitative fingerprint detection method for Shuangyu granules. Background technique [0002] Shuangyu granules are made of 5 herbs: Houttuynia cordata, honeysuckle, red peony root, mugwort leaves, and mint. Nasal congestion, runny nose, cough, expectoration, itchy throat, dry mouth and thirst, sore throat, red tongue, rapid pulse, etc. [0003] The fingerprint of traditional Chinese medicine is of great significance for effectively controlling the quality of traditional Chinese medicinal materials or Chinese patent medicines, and it reflects the chemical substance basis of traditional Chinese medicine to a certain extent. At the same time, combined with quantitative analysis of multi-index components, it has become one of the means of quality control of traditional Chinese medicine. [0004] There is no clear report on the quality con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 萧伟秦建平郎悦林夏仲艳于桂芳李家春王振中
Owner JIANGSU KANION PHARMA CO LTD
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