Inducing method of dry age-related macular degeneration primate model

A primate and macular degeneration technology, applied in the research field of retinal macular degeneration, can solve the problems of prolonged modeling time, inaccurate calculation of feed quantity, and inability to quantify, so as to accelerate the formation of hypercholesterolemia and relieve feed Insufficient intake, the effect of accelerating the induction process

Active Publication Date: 2018-03-13
INST OF ZOOLOGY GUANGDONG ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If high-fat ingredients are mixed into the feed during the replication of the model, most of the feed will be discarded by cynomolgus monkeys and wasted. The daily feed intake of each animal cannot be accurately calculated and quantified.
And because the feed contains high calories, and the taste

Method used

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  • Inducing method of dry age-related macular degeneration primate model
  • Inducing method of dry age-related macular degeneration primate model
  • Inducing method of dry age-related macular degeneration primate model

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Experimental program
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Effect test

Embodiment 1

[0020] 1. Experimental materials

[0021] 1.1 Sucrose: 500g / bottle, analytically pure, Xilong Chemical Industry.

[0022] 1.2 Lard: 15kg / barrel, food grade, Hainan Dingsheng Food Co., Ltd.

[0023] 1.3 Cholesterol: 500g / bottle, analytically pure, Shanghai Boao Biotechnology Co., Ltd.

[0024] 1.4 Bile salt: 500g / bottle, analytically pure, Tianjin Hengxing Chemical Reagent Manufacturing Co., Ltd.

[0025] 1.5 Cynomolgus monkeys: 10-18 years old, 29 males, ordinary grade, purchased from Guangdong Landao Biotechnology Co., Ltd., and animals with myopia and fundus lesions were excluded before purchase.

[0026] 1.6 Triglyceride determination kit, Zhejiang Yilikang Biotechnology Co., Ltd.

[0027] 1.7 Cholesterol assay kit, Zhejiang Yilikang Biotechnology Co., Ltd.

[0028] 1.8 High-density lipoprotein assay kit: Zhejiang Yilikang Biotechnology Co., Ltd.

[0029] 1.9 Low-density lipoprotein assay kit: Zhejiang Yilikang Biotechnology Co., Ltd.

[0030] 2. Main instruments

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Abstract

The invention discloses an inducing method of a dry age-related macular degeneration primate model. The inducing method comprises the steps that a high-glucose and high-fat semifluid diet is injectedinto the stomach of a primate so as to induce the primate to suffer from hypercholesteremia, and then the dry age-related macular degeneration primate model is obtained. By means of the inducing method, the high glucose and high fat which each primate uptakes every day can be quantified without worry about insufficient animal intake caused by taste change, and each primate can regularly and quantificationally uptake the high glucose and high fat, so that the formation of hypercholesteremia is greatly accelerated, and meanwhile, the inducing process of the dry AMD model is accelerated. Comparedwith AMD models induced by other methods, the dry age-related macular degeneration (AMD) primate model has the incomparable advantages and can be used for research, development and assessment of desiccation-resistant AMD drugs, especially for the research, development and assessment of the biotechnology drugs for which a rodent model is not suitable.

Description

Technical field: [0001] The invention belongs to the research field of retinal macular degeneration, and specifically relates to a method for inducing age-related macular degeneration (age-related macular degeneration, AMD) in primates through a high-sugar and high-fat diet. Background technique: [0002] Age-related macular degeneration (AMD) is an irreversible disease of vision loss or loss caused by retinal pigment epithelial cells and neuroretinal degeneration, which mostly occurs in middle-aged and elderly people over 50 years old. Successive or simultaneous onset, progressive damage to vision, is a fundus disease that seriously threatens the visual function of middle-aged and elderly people. According to reports, due to early aging in Western countries, AMD has developed into the first blinding disease, and Asian countries are slightly later than Western countries due to the aging process, and the incidence of the disease is still lower than that of Western countries. ...

Claims

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Application Information

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IPC IPC(8): A01K67/02A23K50/00A23K20/163A23K20/158A23K20/105A61K49/00
CPCA61K49/0008A01K67/02A23K20/105A23K20/158A23K20/163A23K50/00
Inventor 饶军华肖百全李比海刘贻颜
Owner INST OF ZOOLOGY GUANGDONG ACAD OF SCI
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