Racecadotril granules and preparation method thereof

A racecadotril and granule technology is applied to the digestive system, pharmaceutical formulations, medical preparations of inactive ingredients, etc. The effect of short time, good quality and simple preparation method
CN107811973BActive Publication Date: 2019-07-12HAINAN HULUWA PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
HAINAN HULUWA PHARMA GRP CO LTD
Publication Date
2019-07-12

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Abstract

The invention discloses racecadotril granules. Based on 100 bags, the racecadotril granules comprise the following raw medicinal materials and medicinal auxiliary materials in parts by weight: 5g-15gof racecadotril, 1g-5g of coconut oil, 800g-1200g of filler, 100g-200g of an adhesive and 100g-200g of ethanol. The invention also discloses a preparation method of the racecadotril granules. The preparation method comprises the following steps: mixing and stirring ethanol and coconut oil to form a micro-emulsion to increase the solubility of racecadotril; and then adding 1-5% of filler, wherein asmall amount of filler can play a role in a cosolvent accidently, so that the dissolution rate of the racecadotril granules is improved greatly. By adding a lot of filler to modify the taste and cover the bitterness of racecadotril, so that the taste of a drug is improved. The racecadotril granules avoid phenomena that the racecadotril granules prepared by an existing preparation method are poorin taste, poor in dissolution rate and hard to store, and the percent of pass of the product is improved greatly.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to racecadotril granules and a preparation method thereof. Background technique

[0002] The main drug of this product, racecadotril, is an enkephalinase inhibitor, which is a white or off-white crystalline powder, which can selectively and reversibly inhibit enkephalinase, thereby protecting endogenous enkephalins from Degrade and prolong the physiological activity of endogenous enkephalins in the digestive tract. In peripheral tissues, racecadotril taken by IZ1 was rapidly hydrolyzed to acetofen, a more effective enkephalin inhibitor. Inhibition of enkephalinase by acetophene increases opioid utilization, activates intestinal opioid receptors, and leads to decreased mucosal levels of cAMP, thereby reducing excessive secretion of water and electrolytes. Moreover, the drug acts on peripheral enkephalins, does not affect the activity of enkephalinases in the central nervo...

Claims

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