Application of taro leaf alcohol extract in reducing hepatic cell lipidosis

A technology of ethanol extraction and lipid deposition, which is applied in the field of medicine, can solve problems such as easy rebound and lower immunity of the body, and achieve the effect of reducing lipid deposition in HepG2 cells and having a good development prospect

Active Publication Date: 2018-03-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the other weight loss and fat reduction methods also have the disadvantages of lowering the body's immunity and easy rebound.

Method used

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  • Application of taro leaf alcohol extract in reducing hepatic cell lipidosis
  • Application of taro leaf alcohol extract in reducing hepatic cell lipidosis
  • Application of taro leaf alcohol extract in reducing hepatic cell lipidosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1, a kind of preparation method of bean taro leaf ethanol extract, carries out following steps successively:

[0059] 1), mix taro leaves with 85% ethanol containing 0.1mol / L hydrochloric acid in the ratio of 1g:8ml, and use a juice extractor to beat; the obtained slurry is soaked by ultrasonic (40,000Hz ultrasonic frequency) at 45°C After extracting for 240 min, the extract was centrifuged at 4000 rpm for 30 min,

[0060] The filter residue obtained by centrifugation replaces the taro leaves in the above steps and repeats the beating, ultrasonic extraction and centrifugation of the above steps; the number of repetitions is 3 times;

[0061] The supernatants obtained by the above 3 times of centrifugation were combined to carry out the following step 2).

[0062] 2), the obtained supernatant was concentrated by rotary evaporation in a rotary evaporator (the process parameters set by the rotary evaporation were temperature 38°C, vacuum degree -0.09MPa) until ...

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Abstract

The invention discloses application of taro leaf alcohol extract in reducing hepatic cell lipidosis and preparation for drug and healthcare food for treating or preventing the non-alcoholic fatty liver disease. A preparation method for the taro leaf alcohol extract comprises the following steps: mixing and pulping taro leaves and 85% alcohol containing 0.1 mol/L of hydrochloric acid, ultrasonically extracting and centrifuging to obtain liquid supernatant; rotatably evaporating and concentrating the liquid supernatant in a rotary evaporator; and separating and purifying concentrated solution through macroporous resin, taking an methanol aqueous solution containing 0.05% of formic acid as an eluent; rotatably evaporating and concentrating eluant, pre-freezing the slurry concentrated solution, drying the slurry into powder through a vacuum-freezing dryer, thereby obtaining taro leaf alcohol extract.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the preparation of the ethanol extract of bean taro leaves and its application in the preparation of health food and medicine for the prevention and treatment of non-alcoholic fatty liver; at the same time, it relates to the reduction of oleic acid-induced lipid deposition in HepG2 cells in the prevention and treatment of Application in nonalcoholic fatty liver disease. Background technique [0002] Apios americana Medikus is a perennial leguminous plant (Papilionaceae subfamily) native to the eastern part of North America from Canada to the southern part of Florida. Its edible part is the underground tuber, and its protein content is higher than that of other plant tubers. It is a crop with both nutrition and economic value, so it is often used as a staple food by Indians. Bean taro has been successfully introduced in China since 2009, and has been gradually promoted and planted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A23L33/105A61P1/16A61K127/00
CPCA23V2002/00A61K36/48A61K2236/333A61K2236/39A61K2236/51A61K2236/55A23L33/105A23V2200/32A23V2250/21
Inventor 郑晓冬楚强李永璐余露霜刘阳阳
Owner ZHEJIANG UNIV
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