Application of epalrestat in preparation of drug for treating diabetic nephropathy

A technology for diabetic nephropathy and epalrestat is applied to the application of epalrestat in the preparation of a drug for the treatment of diabetic nephropathy. The application field of epalrestat can solve the problem of not having renal function improvement or protection effect, renal injury and side effects And other issues

Inactive Publication Date: 2018-03-27
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main function of clinically used drugs to treat diabetes is to lower blood sugar, and they do not have the eff...

Method used

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  • Application of epalrestat in preparation of drug for treating diabetic nephropathy
  • Application of epalrestat in preparation of drug for treating diabetic nephropathy
  • Application of epalrestat in preparation of drug for treating diabetic nephropathy

Examples

Experimental program
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Embodiment Construction

[0016] The present invention is explained in detail by the following examples, but it does not mean that the present invention is limited thereto.

[0017] Twenty-four db / db mice and 24 wild-type mice (male, purchased from the Model Animal Research Institute of Nanjing University, aged 7 weeks) were used for the experiment. Under the standard feeding environment (eating and drinking freely, alternation of day and night, each 12 hours), adaptive feeding was carried out for one week. Subsequently, the db / db mice were randomly divided into two groups, namely the db / db group and the db / db+Epalrestat group treated with epalrestat; the C57BKLS mice were randomly divided into two groups, namely the WT group and the WT+Epalrestat group treated with epalrestat.

[0018] The experimental design and grouping are as follows: WT group (12 C57BKLS mice), WT+Epalrestat group (12 C57BKLS mice, given epalrestat at a dose of 20 mg / kg body weight by intragastric administration every d...

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Abstract

The invention discloses an application of epalrestat in the preparation of a drug for treating diabetic nephropathy, relating o the technical field of biological medicine. The epalrestat is an only on-sale aldose reductase inhibitor in China and is administered to a db/db mouse through gavage, so that the urinary albumin excretion of the db/db mouse is remarkably reduced, and the pathological injury of the kidney is improved. The orally administered epalrestat disclosed by the invention has a good kidney protection effect, and a candidate drug is provided for the kidney protection of crowds with clinic diabetic nephropathy.

Description

technical field [0001] The invention relates to the application of epalrestat, in particular to the application of epalrestat in the preparation of medicines for treating diabetic nephropathy, and belongs to the technical field of biomedicine. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by long-term higher blood sugar than normal. The incidence of diabetes is increasing worldwide and has become a public health problem. Diabetes has serious complications, among which long-term complications include cardiovascular disease, stroke, chronic kidney disease, peripheral nerve and retinopathy, etc. Diabetic nephropathy is the gradual development of kidney damage. Clinical and pathological examination shows diffuse and nodular glomerulosclerosis. These pathological changes are accompanied by clinical manifestations such as renal edema and proteinuria, and finally directly lead to renal failure. At present, diabetic nephropathy has become the...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61P3/10A61P13/12
CPCA61K31/426
Inventor 王广基阿基业何骏
Owner CHINA PHARM UNIV
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