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Alcohol of euphorbia lathyris as well as preparation method and application thereof

A technology of capers and seeds, which is applied in the field of capers alcohol and its preparation, can solve the problems of insufficient research on chemical components and their biological activities, and achieve the effects of excellent inhibitory effect, high efficiency, and mild reaction conditions

Active Publication Date: 2018-03-27
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the chemical constituents and biological activities of caper seeds is not enough

Method used

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  • Alcohol of euphorbia lathyris as well as preparation method and application thereof
  • Alcohol of euphorbia lathyris as well as preparation method and application thereof
  • Alcohol of euphorbia lathyris as well as preparation method and application thereof

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Effect test

Embodiment 1

[0032] Embodiment 1, the preparation of compound of the present invention

[0033] (1) Take 10kg of caper seeds, crush them into powder, soak them in 80L of ethyl acetate (99.5% by volume) (the weight-volume ratio of caper seeds to ethyl acetate is 1:8g / ml). Filter and extract once every 5 days, and extract 5 times; combine the extracts, recover the solvent under reduced pressure, and obtain the extract of Caperia sativa seeds.

[0034] (2) Take 420g of the above-mentioned extract, dissolve the extract in 12.6L of petroleum ether-acetonitrile (1:1) mixed solution (the weight-to-volume ratio of caper seed extract to petroleum ether-acetonitrile is 1:30g / ml), and extract Three times, the acetonitrile part of the lower layer was obtained; the solvent was recovered from the extract of the acetonitrile part under reduced pressure, and the brown concentrated paste of the acetonitrile part was obtained;

[0035] (3) Mix 284g of the above-mentioned acetonitrile partial concentrate pa...

Embodiment 2

[0047] Embodiment 2, the antitumor activity of the compound of the present invention

[0048] (1) Experimental materials

[0049] Tumor cells: human breast cancer cell MCF-7, human liver cancer cell HepG2, human kidney cancer cell 786-0, breast cancer cell MDA-MB-468; all provided by the Cell Bank of the Chinese Academy of Sciences.

[0050] Preparation of cisplatin solution: Weigh 1.5 mg cisplatin and dissolve it in 50 μL DMSO to obtain a cisplatin solution with a concentration of 100.0 mM. Then take 10.0 μL cisplatin solution with a concentration of 100.0 mM, add 990.0 μL DMEM medium to obtain a cisplatin solution with a concentration of 1000.0 μM; take another 100.0 μL cisplatin solution with a concentration of 1000.0 μM, add 900.0 μL DMEM medium to obtain a concentration 100.0 μM cisplatin solution; take 300.0 μL cisplatin solution with a concentration of 100.0 μL, add 700.0 μL DMEM medium to obtain a cisplatin solution with a concentration of 30.0 μM; take 100.0 μL cispl...

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Abstract

The invention provides a novel compound shown in a formula (I), and a preparation method of the compound shown in the formula (I). Proved by experiment results, the novel compound has the advantages that the fully novel compound is separated from seeds of euphorbia lathyris; the compound has excellent inhibiting function on cancer cells, and can be used for preparing anti-tumor medicines. The preparation method of the compound has the advantages that the reaction conditions are moderate, the energy consumption is low, the efficiency is high, the cost is low, the green and environment-friendlyeffects are realized, and the like; the preparation method is very suitable for industrialized application. (The formula (I) is shown in the attached figure.).

Description

technical field [0001] The invention relates to the field of extraction of natural substances, in particular to caperin alcohol and its preparation method and application. Background technique [0002] Malignant tumors have become one of the most serious diseases that endanger human health. According to the estimation of the World Health Organization, more than 5 million people die from malignant tumors every year in the world, and 10 million new malignant tumor patients are discovered every year. The development of antitumor drugs plays an important role in the treatment of malignant tumors. It has been reported that more than 60% of clinically used anticancer drugs are derived from natural products. Therefore, preventing the development of cancer by studying anticancer substances in natural products has become an important field of cancer prevention research. [0003] Euphorbia lathylris L, also known as Qianjinzi, is a species of Euphorbia lathylris L. Biennial herb, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/80C07D213/803A61K31/4406A61P35/00
CPCC07B2200/07C07D213/80C07D213/803
Inventor 高峰周先礼王稼犀
Owner SOUTHWEST JIAOTONG UNIV
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