Application of total flavonoid extract of tagetes patula in preparing immune enhancing drugs

A technology of immune enhancement and total flavonoids, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., and can solve the problems of less research on medicinal value

Inactive Publication Date: 2018-04-03
蔡德成 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components in the volatile oil of malacock grass are 2-carene, β-phellandrene, piperonone, piperonenone, terpinene, limonene, etc. 1992(01):24-26.; Romagnoli C, Bruni R, Andreotti E, et al.Chemical characterization and antifungal activity of essential oil of capitula from wild Indian Tagetespatula L[J].Protoplasma, 2005, 225(1-2): 57-65), at present, people are doing more research on Malachite flowers, but less research on medicinal value

Method used

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  • Application of total flavonoid extract of tagetes patula in preparing immune enhancing drugs
  • Application of total flavonoid extract of tagetes patula in preparing immune enhancing drugs
  • Application of total flavonoid extract of tagetes patula in preparing immune enhancing drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 prepares the total flavonoids of Malachite

[0017] Preparation of total flavonoids of malachite grass by solvent extraction and resin adsorption:

[0018] 1 kg of malachite grass powder with 10 meshes and 80% ethanol by volume were soaked and extracted twice, each time the amount of solvent was 10 times of the mass of the medicinal material, and soaked at 40°C for 12 hours each time. Combine the extracts, recover the ethanol solution, concentrate to about 1 times the mass of the medicinal material (about 1 liter), and extract 3 times with 500 ml of petroleum ether each time to obtain a degreasing solution. The degreasing solution was eluted with water (2500 milliliters) and 60% ethanol aqueous solution (2000 milliliters) successively through the pretreated HPD100 macroporous adsorption resin column (about 500 milliliters), and the 60% ethanol eluent was recovered under reduced pressure Ethanol, dried under reduced pressure to obtain 105g of total flavonoi...

Embodiment 2

[0019] Embodiment 2: the preparation of malachite total flavonoids tablet

[0020] Recipe: Malachite total flavonoids extract 500g

[0021] Starch 150g

[0022] 5% alcohol solution of polyvinylpyrrolidone in appropriate amount

[0023] Magnesium Stearate 1%

[0024] Made into 1000 pieces

[0025] Preparation method: mix the total flavonoids powder of malachite grass with starch, make a soft material with 5% polyvinylpyrrolidone alcohol solution, granulate with a 16-mesh sieve, granulate after drying, add 1% magnesium stearate, mix and press into tablets, Bottling, sealed storage.

Embodiment 3

[0026] Embodiment 3: the preparation of malachite total flavonoids granule

[0027] Recipe: Malachite total flavonoids extract 500g

[0028] 5% alcohol solution of polyvinylpyrrolidone in appropriate amount

[0029] Make 1000 bags

[0030] Preparation method: Take the total flavonoids powder of Malachite chinensis, make soft material with 5% polyvinylpyrrolidone alcohol solution, granulate with 14 mesh sieve, dry it, pack it into bags, 1g per bag, and seal it for storage.

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Abstract

The invention relates to an application of total flavonoid of tagetes patula in preparing immune enhancing drugs. A method comprises the following steps: crushing whole herb of the tagetes patula, conducting reflux extraction by virtue of ethanol, and implementing degreasing by virtue of petroleum ether; and then, implementing macroporous adsorption resin purification, so that the total flavonoidof tagetes patula is obtained, wherein based upon a colorimetric method, the weight content of the total flavonoid is greater than 30%. Pharmacological tests prove that the total flavonoid extract oftagetes patula is relatively strong in immune enhancing activity, and the total flavonoid extract of tagetes patula can be independently applied to preparations of the immune enhancing drugs or can becombined with other drugs and applied to the preparations of the immune enhancing drugs as a crude drug. In the total flavonoid extract of tagetes patula prepared by the method provided by the invention is high in total flavonoid purity, and the preparation method is simple and practical and is applicable to industrial production; and the total flavonoid extract of tagetes patula provided by theinvention can be used for preparing the drugs having an immune enhancing effect.

Description

technical field [0001] The invention relates to a herbal drug extraction method and application thereof, in particular to a drug extract with malachite total flavonoids as an active ingredient and its application in treating immunosuppressed diseases. Background technique [0002] Peacock grass (Tagetes patula L.), also known as small marigold, red yellow grass, passionflower, stinky chrysanthemum, satin flower (Yunnan), is a plant of the genus Marigold in the Asteraceae family. It is an annual herb with a flowering period from July to September . Originally produced in Mexico, it has been naturalized in central and northwestern Yunnan, central and southwestern Sichuan, and western Guizhou. It is now cultivated in various places in my country. It is a common ornamental flower. Peacock grass has medicinal and health care functions, and is used as medicine in the Lisu and Yi nationalities. Its taste is bitter and flat, clearing away heat and promoting dampness, relieving cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P37/04
CPCA61K36/28A61K2236/33A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 蔡德成窦德强
Owner 蔡德成
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